DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8907 and EPS8L3

DIOPT Version :9

Sequence 1:NP_001247146.1 Gene:CG8907 / 42050 FlyBaseID:FBgn0038466 Length:732 Species:Drosophila melanogaster
Sequence 2:XP_011540434.1 Gene:EPS8L3 / 79574 HGNCID:21297 Length:602 Species:Homo sapiens


Alignment Length:724 Identity:169/724 - (23%)
Similarity:263/724 - (36%) Gaps:229/724 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 KPT---YALEHLATFKLKNEAEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDMKE 105
            :||   :.:|||.|.| :....|:.|::.::.|.|::..|.:|...:.:.....||.:||.:.||
Human    23 EPTLLQHRVEHLMTCK-QGSQRVQGPEDALQKLFEMDAQGRVWSQDLILQVRDGWLQLLDIETKE 86

  Fly   106 IENFPGSLITEPTAFISDHPQE--------SFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVE 162
                      |..::..|..|.        |:|:||..:|....|..|...:||..:|.:    |
Human    87 ----------ELDSYRLDSIQAMNVALNTCSYNSILSITVQEPGLPGTSTLLFQCQEVGA----E 137

  Fly   163 DLKT-LSK--------------GTPVTVDRNKTPIL---LP-----------KPERPQNQQAKDQ 198
            .||| |.|              |.....||.:.|.:   ||           .||:| :|:..:.
Human   138 RLKTSLQKALEEELEQSRPRLGGLQPGQDRWRGPAMERPLPMEQARYLEPGIPPEQP-HQRTLEH 201

  Fly   199 YGIAAAVAGI------------AAEKNAI---------DKEQTERDVQVINHCFEDIERFMARLH 242
            ...:...||:            |.|.:|.         ..|..|||.:|:||...|||.||.:|.
Human   202 SPWSPYTAGLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEEVLNHVLRDIELFMGKLE 266

  Fly   243 YAAEALNELKLRKEQHNPHGEGLLVLRSRPPIESEFHDILAKAKLALIYSVRLQNQFTKPADP-- 305
             .|:|....|.:..:.|....||        .::::.|...|.|.:.....||.....:.:.|  
Human   267 -KAQAKTSRKKKFGKKNKDQGGL--------TQAQYIDCFQKIKHSFNLLGRLATWLKETSAPEL 322

  Fly   306 VHNVFISLKSIVTVCNDIYVDAGLPQAVLNPLLRRETIAFLNGTLDSNEMQLWQSLGPNWTVPK- 369
            ||.:|.||..|:..|    .:|||...|::|||..:.|..|...|...|..||..|||.||..: 
Human   323 VHILFKSLNFILARC----PEAGLAAQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRA 383

  Fly   370 DQFKDHKSSYHPIFYDDWS-PDWVVDEEVPYLAP-ALKK------STT--PSPVPVPMPPSPGLG 424
            |...|....|.|.|.|||. |:......:.|..| :|::      ||:  |........|.||..
Human   384 DWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDP 448

  Fly   425 NRTWLSRLESRNVKIAEVTFNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVL 489
            |....|...::.....:|.:...|.|.:||.|.:||.||::|.|:.||..:|..|..||:|..:|
Human   449 NSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNIL 513

  Fly   490 TPYNFEPGVNGRDTESLASMALTENGGEEAIPPPLYRNTMAMYTAPVEQPAANGKAMQRTFSMPN 554
            .|  .:||.                                        |...|::..|.     
Human   514 EP--LQPGT----------------------------------------PGTQGQSPSRV----- 531

  Fly   555 VPVPPPMPPPSDSQTPTPSGTLKRNMAAAGALAAMRARNDCEADDQLYYMQGDVHDELRLLQQQR 619
                 ||                                                  |||     
Human   532 -----PM--------------------------------------------------LRL----- 536

  Fly   620 ERRKDLEILKTPEIFITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHTIESYFGRR 684
                              :|:|.||.:||:.:.||...::.|.:|:|.::..:.|..:: ....:
Human   537 ------------------SSRPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQ-MLCPQ 582

  Fly   685 ESRRLISQI 693
            |:.|::|::
Human   583 EAPRILSRL 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8907NP_001247146.1 PTB_EPS8 43..175 CDD:269921 39/156 (25%)
SH3_Eps8 439..492 CDD:212698 20/52 (38%)
SAM_superfamily 635..699 CDD:301707 15/59 (25%)
EPS8L3XP_011540434.1 PTB_EPS8 25..154 CDD:269921 37/143 (26%)
SH3_Eps8 464..516 CDD:212698 21/53 (40%)
SAM_superfamily 533..598 CDD:301707 19/133 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151766
Domainoid 1 1.000 64 1.000 Domainoid score I10104
eggNOG 1 0.900 - - E1_KOG3557
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D118943at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42216
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12287
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.810

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