Protein Alignment CG8907 and eps8

DIOPT Version :10

• Sequence 1: NP_001247146.1
• Gene: CG8907 / 42050
• FlyBaseID: FBgn0038466
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001072508.1
• Gene: eps8 / 779963
• XenbaseID: XB-GENE-996936
• Length: 788
• Species: Xenopus tropicalis
• Alignment Length: 818
• Identity: 215/818 - (26%)
• Similarity: 357/818 - (43%)
• Gaps: 169/818 - (20%)

  Fly    20 GMPQNGYENGV-PGGNQANGH------------------YDEVK-------------PTYALEHL 52
            |...:.|..|. ||....||:                  |::.|             ..|.:|||
 Frog     3 GQISSSYRGGFGPGSQHPNGYDSPRSDRQSSSKISAKSIYEQRKNYARDTVSSLSETSQYHIEHL 67

  Fly    53 ATFKLKNEAEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDMK-EIENFPGSLITE 116
            .||.:..:..|....:.::.|..|:..|.:|...|.:..:.:.:.:.|.|.| |:||||.|.:
 Frog    68 TTFVMDRKDGVLTVDDGIRKLKLLDAKGKVWTQDMLLQVDDKGVSLYDVDTKSELENFPLSSV-- 130

  Fly   117 PTAFISDHPQESFN-----NILIFSVPGISLGNTEMHIFQVADVSSVLLVEDLKTL---SKG--- 170
                  .|.|...|     :||.......:....::|:||..::.:.|:..|:.:.   |||
 Frog   131 ------QHCQAVMNACRYDSILALVCKEPAQSKADLHLFQCDEIKASLVQRDIDSAISDSKGGKQ 189

  Fly   171 -------TPVTVDRNKTPIL--LPKPERPQNQQAKDQYGIAAAVAGIAAE-------KNAIDKEQ 219
                   ..:|.:.:|.|..  .|.|..|.:....|.....||.:..|:|       :..:|::.
 Frog   190 KKRPEALRAITRNDDKIPPHPGAPAPTPPGSVTQVDVRSRVAAWSSWASEYGDYDPSRQNLDQDS 254

  Fly   220 T--------ERDVQVINHCFEDIERFMARLHYAAEALNELKLR---KEQHNPHGEGLLVLRSRPP 273
            |        :||||::||..:|:|.|:.:|..||||.:||..|   |::..| |||:|.||:|||
 Frog   255 TPEMLEARIDRDVQILNHILDDVEFFIMKLQKAAEAFSELSKRKKGKKKKGP-GEGVLTLRARPP 318

  Fly   274 IESEFHDILAKAKLALIYSVRLQNQFTKP--ADPVHNVFISLKSIVTVCNDIYVDAGLPQAVLNP 336
            .:.||.|...|.|..:....:|::....|  ::.||.:|..|..:|....    ...|.:.||:|
 Frog   319 PQEEFVDCFQKFKHGINLLAKLKSHIQNPSASELVHFLFTPLHMMVEATG----GPDLARTVLSP 379

  Fly   337 LLRRETIAFLNGTLDSNEMQLWQSLGPNWTV-----PKDQFKDHKSSYHPIFYDDWSPDWV---- 392
            |:.::::.|||..|:..|.|||.|||.:|..     ||:||   ...|.|.|.:.|.|..:
 Frog   380 LITKDSLDFLNFILNKEEKQLWTSLGDSWNKYRAEWPKEQF---IPPYVPRFRNGWEPPLLGCAA 441

  Fly   393 --VDEEVPYLAPA------LKKSTTPSPVP------VPMPPSPGLGNRTWLSRLESRNVKIAEVT 443
              .::|:.|||.:      |::....:.||      ...|||.  ||.....::|::...:.:..
 Frog   442 APKEQELSYLAESVANVAELQRKQEFNSVPNMYSHVSRYPPSE--GNFEERDQVEAQRYALCKYD 504

  Fly   444 FNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVLTPYNFEPGVNGRDTESLAS 508
            |  .|.|..||.|.|.:.||::||.:.|||.|:|.|.:|:||:.:|..  .:|     ..:|...
 Frog   505 F--VARNSNELSVLKDDVLEVLDDKKQWWKVRSSSGAVGFVPNNILVA--MKP-----QDQSAKP 560

  Fly   509 MALTENGGEEAIPPPLYRNTMAMYTAPVEQPAANGKAMQRTFSMPNVPVPPPMPPP-----SDSQ 568
            |        ||    .|.:|:....:.:.|..|.        .:|..|.|||.|.|     ::||
 Frog   561 M--------EA----AYTHTIQKQKSDLIQSQAG--------PIPAAPSPPPNPAPTYSPLANSQ 605

  Fly   569 TPT-------PSGTLKRNM-----AAAGALAAMRARNDCEADDQLYYMQGDVHDEL--RLLQQQR 619
            .||       .:|.:.|..     :..|::..........||.:...|: :|.|||  ||...:.
 Frog   606 QPTLPVAKLFTAGPISRQSSLSSDSGGGSVREQHGLQQVPADRRKSQME-EVQDELIHRLTIGRS 669

  Fly   620 ERRKDLEI--LKTPEIFITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHTIESYFG 682
            ..:|...:  |..|.:.|:.:|...:|:.||:.|||:.:.:..|..|:|.::|:|:...:::..
 Frog   670 AAQKKFTVPRLNAPAVHISYSSPAEDVKSWLQAKGFNSVTVDSLGVLTGAQLFSLTKDELKTVC- 733

  Fly   683 RRESRRLISQIVLQKNFCEYKTIRSSELSAKLARARQK 720
             .|..|:.:|:.:||...|.:: ..||| .::.:.||:
 Frog   734 -PEGPRVYNQVTVQKAAIEEQS-GGSEL-LEIMKKRQE 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	35/163 (21%)
		SH3_Eps8	439..492	CDD:212698	21/52 (40%)
		SAM_3	630..693	CDD:436214	16/62 (26%)
eps8	NP_001072508.1	PTB_EPS8	58..188	CDD:269921	34/137 (25%)
		SH3_Eps8	498..551	CDD:212698	21/56 (38%)
		SAM_EPS8-like	686..750	CDD:188939	18/65 (28%)