DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8907 and Eps8l1

DIOPT Version :9

Sequence 1:	NP_001247146.1	Gene:	CG8907 / 42050	FlyBaseID:	FBgn0038466	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001361551.1	Gene:	Eps8l1 / 67425	MGIID:	1914675	Length:	777	Species:	Mus musculus

Alignment Length:	755	Identity:	189/755 - (25%)
Similarity:	315/755 - (41%)	Gaps:	161/755 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 YALEHLATFKLKNEAEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDMK-EIENFP 110
            |.:.||.||.|..|..|...::..:.|..::..|.:|..:|.:..:...:.:||...| |:|::|
Mouse    97 YHVNHLVTFCLGEEDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPSQVTLLDPVSKEELESYP 161

  Fly   111 GSLITEPTAFISDHPQESFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVEDL----------- 164
            ...|....|.:   |:....::|:...........::|.||...:.:.|:.||:
Mouse   162 LDAIVRCDAVM---PRGRSRSLLLLVCQEPERAQPDVHFFQGLLLGAELIREDIQGALQNYRSGR 223

  Fly   165 ------------KTLSKGTPVTVDRNKTPILLPKPE---------------RPQ------NQQAK 196
                        :.|.:|.....:   ||.|..:|.               |||      .::|:
Mouse   224 GERRAAALRATQEELRRGASPAAE---TPPLQRRPSVRLVINTVEPSAVRGRPQVESIPETEEAR 285

  Fly   197 --DQYGIAAAVAGIAAEKNAIDKE----QTERDVQVINHCFEDIERFMARLHYAAEALNEL---- 251
              ||....::....:.:......|    |.||||.::||.|:|:|.|::||..:|||...|
Mouse   286 KPDQARTTSSADPTSPDLGPRGPELAGLQAERDVDILNHVFDDVESFVSRLQKSAEATRVLEHRE 350

  Fly   252 KLRKEQHNPHGEGLLVLRSRPPIESEFHDILAKAKLALIYSVRLQNQFTKPADP--VHNVFISLK 314
            :.|:.:....|||||.||::||.|:|:.|:|.|.|.|.....||:.....|:.|  :|.:|..|:
Mouse   351 RGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARLRGNIANPSSPELLHFLFGPLQ 415

  Fly   315 SIVTVCNDIYVDAGLPQ---AVLNPLLRRETIAFLNGTLDSNEMQLWQSLGPNWTVPKDQFKDHK 376
            .||..       :|.|:   :|..|.|..|.:..|...:...|.:||.|||.:||.|..:....:
Mouse   416 MIVNT-------SGGPEFAKSVRRPHLTLEAVTLLRDNVTPGENELWTSLGDSWTCPGVELPPEE 473

  Fly   377 SS-YHPIFYDDWSPDWVVDEEVPYLAPALK--------KSTTPSPVPVPMPPSPGLGNRTWLSRL 432
            .| |.|.||:.|.|.....:..|:..|..|        :..:...|.|.....|.|...   |:|
Mouse   474 GSPYSPEFYNGWEPPATDPQGRPWEDPVEKQLQHEKRRRQQSAPQVAVNGQQDPELETE---SQL 535

  Fly   433 ESRNVKIAEVTFNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVLTPYNFEPG 497
            |.:..|.....::..|.|..||.|...:.||::||.|.|||.|:..|..||||:.:|||:   ||
Mouse   536 EEKARKWVLCNYDFQARNGSELSVKHRDVLEVLDDRRKWWKVRDHQGQEGYVPYNILTPH---PG 597

  Fly   498 VNGRDTESLASMALTENGGEEAIPPPLYRNTMAMYTAPVEQPAANGKAMQRTFSMPNVPVPPPMP 562
                                    |.::|:         :.||.:.:.        :.|.|||.|
Mouse   598 ------------------------PQVHRS---------QSPARHLET--------STPPPPPAP 621

  Fly   563 PPSDSQTPTPSGTLKRNMAAAGALAAMRARND-CEADDQLYYMQGD-------VHDEL--RLLQQ 617
            .|:.:|                    :|.:.| |::.:.|...:.:       |::||  ||.|.
Mouse   622 APAPTQ--------------------VRPQWDSCDSLNSLDPSEKEKFSQMLCVNEELQSRLAQG 666

  Fly   618 QRERRKDLEILKTPEIFITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHTIESYFG 682
            :....:.....:..|..::..|:.|.|..||:.||||...::.|..|:|.::|:|....:.:..
Mouse   667 RSGPSRVTPGPRAQEPQLSPRSEASVVRAWLQTKGFSSGTVEALGVLTGAQLFSLQKEELRAVC- 730

  Fly   683 RRESRRLISQIVLQKNFCEYKTIRSSELSAKLARARQKAD 722
            ..|..|:.||:.:|:...|.:. :.|||.|.:.:.::|.:
Mouse   731 PEEGARVYSQVTVQRALLEDRE-KVSELEAVMEKQKKKVE 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	30/151 (20%)
		SH3_Eps8	439..492	CDD:212698	21/52 (40%)
		SAM_superfamily	635..699	CDD:301707	19/63 (30%)
Eps8l1	NP_001361551.1	PTB_EPS8	93..223	CDD:269921	28/128 (22%)
		COG5373	220..>307	CDD:227665	12/89 (13%)
		SH3_Eps8	542..594	CDD:212698	20/51 (39%)
		SAM_EPS8-like	683..748	CDD:188939	19/65 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841869
Domainoid	1	1.000	116	1.000	Domainoid score	I5931
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47799
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	1	1.000	-	-		otm44271
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.820