DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8907 and EPS8L2

DIOPT Version :9

Sequence 1:NP_001247146.1 Gene:CG8907 / 42050 FlyBaseID:FBgn0038466 Length:732 Species:Drosophila melanogaster
Sequence 2:NP_073609.2 Gene:EPS8L2 / 64787 HGNCID:21296 Length:715 Species:Homo sapiens


Alignment Length:786 Identity:208/786 - (26%)
Similarity:324/786 - (41%) Gaps:185/786 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 MPQNGYENGVPGG-NQANGHYDEV------------------------KPTYALEHLATFKLKNE 60
            |.|:|..:..||. |.:.|..|.|                        ...|.::|||||.:...
Human     1 MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKS 65

  Fly    61 AEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLD-SDMKEIENFPGSLITEPTAFISDH 124
            ..:....:.::.||:|.....||..:|.:..|.|.|.:|| ...:|:|:||...:......::  
Human    66 EAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLN-- 128

  Fly   125 PQESFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVEDLKTL-------SKGTPVTVDRNKTPI 182
             |..:.::|:...........::|.|...:|.:.|:.||:::.       .|..|.|:..::..|
Human   129 -QLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKI 192

  Fly   183 -----LLPKPERP----------QNQQAKDQYG--IAAAVAGI-----AAEKNAIDKEQTERDVQ 225
                 :||.|:.|          .:.:||::.|  :..:..|.     ..|..|:..::.|::.|
Human   193 RQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQ 257

  Fly   226 VINHCFEDIERFMARLHYAAEALNELKLRKE-----QHNPHGEGLLVLRSRPPIESEFHDILAKA 285
            ::|...:|||.|:|||..||||..:|..||:     :..| .||:|.||:|||.|.||.|...|.
Human   258 ILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAP-AEGVLTLRARPPSEGEFIDCFQKI 321

  Fly   286 KLALIYSVRLQNQFTKP--ADPVHNVFISLKSIVTVCNDIYVDAGLPQAVLNPLLRRETIAFLNG 348
            |||:....:||.....|  |:.||.:|..|..||..|:    ...:.::|..|||.|:.:.||.|
Human   322 KLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCS----GPDIARSVSCPLLSRDAVDFLRG 382

  Fly   349 TLDSNEMQLWQSLGPNWTVPKDQF--KDHKSSYHPIFYDDWSP--------DWVVD-------EE 396
            .|...||.||:|||.:|..|:.::  :.....|.|.|:..|.|        .|.|:       ||
Human   383 HLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEE 447

  Fly   397 V-PYLAPALKKSTTPSPVPVPMPPSPGL-------GNRTWLSRLESRNVKIAEVTFNKSATNDKE 453
            | |....:::.|...||...|.||...|       .:|.:  :......|..::.::.:|.|..|
Human   448 VSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGY--QPTPAMAKYVKILYDFTARNANE 510

  Fly   454 LKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVLTPYNFEPGVNGRDTESLASMALTENGGEE 518
            |.|.|.|.||:::|.|.|||.|:..|..||||..:|                  ..|..|:.|  
Human   511 LSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNIL------------------GEARPEDAG-- 555

  Fly   519 AIPPPLYRNTMAMYTAPVEQPAANGKAMQRTF--SMPNVPVPPPMPPPSDSQTPTPSGTLKRNMA 581
                           ||.||      |.|:.:  :.|...:||..|...                
Human   556 ---------------APFEQ------AGQKYWGPASPTHKLPPSFPGNK---------------- 583

  Fly   582 AAGALAAMRARNDCEADDQLYYMQGDVHDEL-------RLLQQQRERRKDLEILKTPEIFITQNS 639
                             |:|.....:|:|||       |...|:..|.:..:.:..|   :|..|
Human   584 -----------------DELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQP---LTYES 628

  Fly   640 KPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHTIESYFGRRESRRLISQIVLQKNFCEYKT 704
            .|.||..||..|.||..|::.|..|:|.::|:|:...::...| .|..|:.||:.:||.|.| |.
Human   629 GPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELKKVCG-EEGVRVYSQLTMQKAFLE-KQ 691

  Fly   705 IRSSEL 710
            ...|||
Human   692 QSGSEL 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8907NP_001247146.1 PTB_EPS8 43..175 CDD:269921 32/163 (20%)
SH3_Eps8 439..492 CDD:212698 21/52 (40%)
SAM_superfamily 635..699 CDD:301707 23/63 (37%)
EPS8L2NP_073609.2 PTB_EPS8 48..178 CDD:269921 29/132 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..243 10/59 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..487 10/38 (26%)
SH3_Eps8 496..546 CDD:212698 20/49 (41%)
SAM_EPS8-like 623..688 CDD:188939 24/68 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151768
Domainoid 1 1.000 118 1.000 Domainoid score I5844
eggNOG 1 0.900 - - E1_KOG3557
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D118943at33208
OrthoFinder 1 1.000 - - FOG0001461
OrthoInspector 1 1.000 - - otm42216
orthoMCL 1 0.900 - - OOG6_106655
Panther 1 1.100 - - O PTHR12287
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4036
SonicParanoid 1 1.000 - - X1022
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.740

Return to query results.
Submit another query.