DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8907 and eps8b

DIOPT Version :9

Sequence 1:	NP_001247146.1	Gene:	CG8907 / 42050	FlyBaseID:	FBgn0038466	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_021323458.1	Gene:	eps8b / 564779	ZFINID:	ZDB-GENE-060503-164	Length:	239	Species:	Danio rerio

Alignment Length:	308	Identity:	80/308 - (25%)
Similarity:	125/308 - (40%)	Gaps:	87/308 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 LESRN--VKIAEVTFNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVLTPYNF 494
            ||..|  ::...:.::..|.|..||.|.:|:.||::::::.||..||..|..||||..||
Zfish     2 LEPSNSDLQHVRIRYHFVARNANELTVQQGDELEVLENNQQWWLLRNRSGQSGYVPCNVL----- 61

  Fly   495 EPGVNGRDTESLASMALTENGGEEAIPPPLYRNTMAMYTAPVEQPAANGKAMQRTFSMPNVPVPP 559
                                  ||..|.....|..|::::....|      .:.|.:.| |||
Zfish    62 ----------------------EEVKPEEQQYNRAALFSSQAVNP------YKGTTTSP-VPV-- 95

  Fly   560 PMPPPSDSQTPTPSGTLKRNMAAAGALAAMRARNDCEADDQLYYMQGDVHDEL------------ 612
                               |.|.  .|...::..|.:..||    |.:|:|||
Zfish    96 -------------------NHAV--VLEMNKSSRDKDNRDQ----QKEVNDELLKRITDNKAQPP 135

  Fly   613 -RLLQQQRERRKDLEILKTPEIFITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHT 676
             |..:.:|..|         .|.||..|:|.||..||..||||..:::.|..|:|.::|:||...
Zfish   136 ARNFRVERSSR---------SIRITDESQPFEVHAWLNAKGFSRPVVECLGILNGAQLFSLSKDE 191

  Fly   677 IESYFGRRESRRLISQIVLQKNFCEYKTIRSSELSAKLARARQKADQS 724
            :::..| .|..|:.|||.:||...| :....:||...:.|.:|:.|.:
Zfish   192 LKAVCG-DEGSRVYSQITVQKAQIE-RGNGDTELQEIMRRRQQEVDST 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921
		SH3_Eps8	439..492	CDD:212698	19/52 (37%)
		SAM_superfamily	635..699	CDD:301707	26/63 (41%)
eps8b	XP_021323458.1	SH3	12..64	CDD:327375	20/78 (26%)
eps8b	XP_021323458.1	SAM_EPS8-like	150..214	CDD:188939	26/64 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586352
Domainoid	1	1.000	56	1.000	Domainoid score	I10958
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750