Protein Alignment CG8907 and EPS8L1

DIOPT Version :10

• Sequence 1: NP_001247146.1
• Gene: CG8907 / 42050
• FlyBaseID: FBgn0038466
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_005259077.1
• Gene: EPS8L1 / 54869
• HGNCID: 21295
• Length: 755
• Species: Homo sapiens
• Alignment Length: 791
• Identity: 195/791 - (24%)
• Similarity: 317/791 - (40%)
• Gaps: 194/791 - (24%)

  Fly    47 YALEHLATFKLKNEAEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLD-SDMKEIENFP 110
            |.:.||.||.|..:..|...::..:.|..::..|.:|..:|.:..:...:.:|| :..:|:|::|
Human    36 YPVNHLVTFCLGEDDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYP 100

  Fly   111 GSLITEPTAFISDHPQESFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVEDLK---------- 165
            ...|....|.:   |.....::|:...........::|.||...:.:.|:.||::
Human   101 LGAIVRCDAVM---PPGRSRSLLLLVCQEPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGR 162

  Fly   166 -----TLSKGTPVTVDRNK-----TPILLPKPE---------------RPQNQ---QAKDQYGIA 202
                 ...:.|...:.|::     ||.|..:|.               |||.:   :|::    |
Human   163 GERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEE----A 223

  Fly   203 AAVAGIAAEKNAIDKE-------------QTERDVQVINHCFEDIERFMARLHYAAEALNEL--- 251
            .....:....||....             |.||:|.::||.|:|:|.|::||..:|||...|
Human   224 QRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHR 288

  Fly   252 -KLRKEQHNPHGEGLLVLRSRPPIESEFHDILAKAKLALIYSVRLQNQFTKPADP--VHNVFISL 313
             :.|:.:....|||||.||::||.|:|:.|:|.|.|.|.....||:.....|:.|  :|.:|..|
Human   289 ERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPL 353

  Fly   314 KSIVTVCNDIYVDAGLPQ---AVLNPLLRRETIAFLNGTLDSNEMQLWQSLGPNWTVPKDQFKDH 375
            :.||..       :|.|:   :|..|.|..:.:|.|...:...|.:||.|||.:||.|..:....
Human   354 QMIVNT-------SGGPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPE 411

  Fly   376 KS-SYHPIFYDDWSPD--------WVVDEEVPYLAPALKKSTTPSPVPVPMPPSPGLGNRTW--L 429
            :. .|.|.|:..|.|.        |....|........::..|.:..........|.|...|  |
Human   412 EGPPYRPEFFSGWEPPVTDPQSRAWEDPVEKQLQHERRRRQVTQATQQGRGWEVRGRGRSAWPRL 476

  Fly   430 SR---------------------------LESRNV-KIAEVTFNKSATNDKELKVTKGEYLEIID 466
            :|                           |||... |.....::..|.|..||.|.:.:.||::|
Human   477 TRLSYFLQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLD 541

  Fly   467 DSRNWWKARNSYGNIGYVPHTVLTPYNFEPGVNGRDTESLASMALTENGGEEAIPPPLYRNTMAM 531
            |||.|||.|:..|..||||:.:||||   ||                        |.|:.:
Human   542 DSRKWWKVRDPAGQEGYVPYNILTPY---PG------------------------PRLHHS---- 575

  Fly   532 YTAPVEQPAANGKAMQRTFSMPNVPVPPPMPPPSDSQTPTPSGTLKRNMAAAGALAAMRARND-- 594
                 :.||.         |:.:.|.|||.|.|:    |.|            |||  |.|.|
Human   576 -----QSPAR---------SLNSTPPPPPAPAPA----PPP------------ALA--RPRWDRP 608

  Fly   595 ----CE-------ADDQLYYMQGDVHDEL--RLLQQQRERRKDLEILKTPEIFITQNSKPSEVEE 646
                |:       ::.:.:.....|::||  ||.|.:....:.:...:.||..::..|..|||..
Human   609 RWDSCDSLNGLDPSEKEKFSQMLIVNEELQARLAQGRSGPSRAVPGPRAPEPQLSPGSDASEVRA 673

  Fly   647 WLRGKGFSDIIIKRLHTLSGEEIFALSPHTIESYFGRRESRRLISQIVLQKNFCEYKTIRSSELS 711
            ||:.||||...:..|..|:|.::|:|....:.: ....|..|:.||:.:|::..|.|. :.|||.
Human   674 WLQAKGFSSGTVDALGVLTGAQLFSLQKEELRA-VSPEEGARVYSQVTVQRSLLEDKE-KVSELE 736

  Fly   712 AKLARARQKAD 722
            |.:.:.::|.:
Human   737 AVMEKQKKKVE 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	27/143 (19%)
		SH3_Eps8	439..492	CDD:212698	22/52 (42%)
		SAM_3	630..693	CDD:436214	20/62 (32%)
EPS8L1	XP_005259077.1	PTB_EPS8	32..162	CDD:269921	26/128 (20%)
		SH3_Eps8	514..567	CDD:212698	22/52 (42%)
		SAM_EPS8-like	661..726	CDD:188939	20/65 (31%)