Protein Alignment CG8907 and eps8a

DIOPT Version :9

• Sequence 1: NP_001247146.1
• Gene: CG8907 / 42050
• FlyBaseID: FBgn0038466
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: XP_009298188.1
• Gene: eps8a / 393212
• ZFINID: ZDB-GENE-040426-871
• Length: 872
• Species: Danio rerio
• Alignment Length: 888
• Identity: 241/888 - (27%)
• Similarity: 366/888 - (41%)
• Gaps: 243/888 - (27%)

  Fly    24 NGYENGVPGGNQANGH-----------------YDEVK-------------PTYALEHLATFKLK 58
            |||   .|..:|.|||                 |::.|             ..|.:|||.||.:.
Zfish    17 NGY---TPPASQMNGHGSLSPDVPGKKSSGKALYEQRKNYTKNSINSLTDTSQYHVEHLTTFVMD 78

  Fly    59 NEAEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDMK-EIENFP-GSLITEPTAFI 121
            .:..:...::.::.|..|:..|.||...|.:..:.:.:.::|.|.| |:|||| ||:
Zfish    79 RKEAMLTIEDGIRKLRLLDAKGKIWTQDMLLQVDNRAVSLIDHDSKNELENFPLGSI-------- 135

  Fly   122 SDHPQE-----SFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVEDLKTL---SKGTPVTVDRN 178
             .|.|.     |:::||.........|..::|:||..|:.:.|:..|:::.   .||..:    .
Zfish   136 -QHCQPVTNACSYDSILALVCKESGQGKPDLHLFQCEDIKASLIHMDIESAISDHKGGKI----K 195

  Fly   179 KTPILL-----------PKP--ERPQNQQAKDQYGIAAAVAGIAAEKN----------------- 213
            |.|.:|           |.|  ..||...|.:|....:.||..:|..|
Zfish   196 KRPEVLKMILKSDGSIPPPPGGPAPQAPAAVNQVDTKSRVASWSAWTNEQQDNDPQRHYTELDTP 260

  Fly   214 -AIDKEQTERDVQVINHCFEDIERFMARLHYAAEALNEL----KLRKEQHNPHGEGLLVLRSRPP 273
             .:...|.:||||::||..:|||.|:.:|..||||.|||    |.:|.:....|||:|.||::||
Zfish   261 PEMSAAQVDRDVQILNHILDDIEHFVTKLQKAAEAFNELSKRKKSKKSKKKGPGEGVLTLRAKPP 325

  Fly   274 IESEFHDILAKAKLALIYSVRLQNQFTKPA--DPVHNVFISLKSIVTVCNDIYVDAGLPQAVLNP 336
            .:.||.|...|.|.|.....:|:|....|:  |.||.:|..||.::.....:    .|.::|:.|
Zfish   326 TQDEFIDCFQKFKHAFNLLGKLKNHIQNPSAVDLVHFLFNPLKLVIQTSGGV----DLAKSVVVP 386

  Fly   337 LLRRETIAFLNGTLDSNEMQLWQSLGPNWTV-----PKD-QFKDHKSSYHPIFYDDWSPDWVV-- 393
            ||.||.|.||:....:.|..||.:||..||.     ||| .|..|..|    |.|.|.|..:|
Zfish   387 LLTREAIEFLHTAGSAEERHLWVTLGDAWTKCKLEWPKDYPFPSHTLS----FRDGWEPPVLVSR 447

  Fly   394 DEEVPYLAPALK--KSTTPSPVPVPM--------PPSPGLGNRTW--LSRLE------------S 434
            :::|..||..|.  :|.||.| |:..        ....||.:.|.  |.:||            |
Zfish   448 EQDVTQLAERLNAAQSETPRP-PITQQTVQDFSSADGYGLTHATHKRLHQLETDMAMAALKHAVS 511

  Fly   435 RNV--------KIAEVTFNKS-----ATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPH 486
            |:|        :.|:..|.||     |.|:.||.|.|.|.:|::||.:.|||.||..|..||||:
Zfish   512 RHVDRNLDAHSRTAQRNFAKSKYDFVARNNTELSVLKDEVVEVLDDRKQWWKVRNGAGASGYVPN 576

  Fly   487 TVLTPYNFEPGVNGRDTESLASMALTENGGEEAIPPPLYRNTMAMYTAPVE-----QPAANGKAM 546
            .:|              |...::.:|..|      .|:|.:|:.:.....|     |........
Zfish   577 NIL--------------EISRAVDMTGRG------EPIYSHTIQLMMPKKEFELFKQLLGELNEK 621

  Fly   547 QRTFSMPN------VPVPPPMPPPSDSQTPTPSGTLKRNMAAAG-----------------ALAA 588
            |||..:|.      .|.|.|.|||: ...||.|   ..|.:||.                 |:|.
Zfish   622 QRTDYVPRPTVTEAPPTPTPPPPPA-PLLPTAS---PANQSAAAIIPANQSTGATSPANQRAVAT 682

  Fly   589 MRARNDCEADDQLYYMQ---GDVHDE-------LRLLQQQRE-------RRKDLEILK------- 629
            ..|.....|.||....:   |:.||:       :.:.:||||       |:.::|.::
Zfish   683 SPANQSTAAADQANQSESNSGEQHDDTVSESDSVNMREQQRERAAPANRRKSNMEEVQDELMYRL 747

  Fly   630 -----------------TPEIFITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHTI 677
                             .|.:.|:.:|.|.:|::||..||||...:..|..|:|.::|:|:...:
Zfish   748 TLGRSAQKRIQTPSRSSQPALSISYDSTPQQVKDWLMLKGFSAATVSSLGVLTGAQLFSLNKDEL 812

  Fly   678 ESYFGRRESRRLISQIVLQKNFCEYKTIRSSELSAKLARARQK 720
            ::.. ..:..|:.|||.:||...|..:  .|||...:.|.::|
Zfish   813 KTVC-PDDGARVFSQISVQKAALERSS--GSELMEVMRRRQEK 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	37/154 (24%)
		SH3_Eps8	439..492	CDD:212698	25/57 (44%)
		SAM_superfamily	635..699	CDD:301707	21/63 (33%)
eps8a	XP_009298188.1	PTB_EPS8	63..193	CDD:269921	36/138 (26%)
		SH3_Eps8	529..581	CDD:212698	24/65 (37%)
		SAM_EPS8-like	770..834	CDD:188939	21/64 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5861
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2853
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	1	1.000	-	-		otm26368
orthoMCL	1	0.900	-	-		OOG6_106655
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4036
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000