Protein Alignment CG8907 and Eps8l1

DIOPT Version :10

• Sequence 1: NP_001247146.1
• Gene: CG8907 / 42050
• FlyBaseID: FBgn0038466
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001101937.1
• Gene: Eps8l1 / 361503
• RGDID: 1311146
• Length: 717
• Species: Rattus norvegicus
• Alignment Length: 763
• Identity: 193/763 - (25%)
• Similarity: 306/763 - (40%)
• Gaps: 176/763 - (23%)

  Fly    47 YALEHLATFKLKNEAEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDMK-EIENFP 110
            |.:.||.||.|..|..|...::..:.|..::..|.:|..:|.:..:...:.:||...| |:|::|
  Rat    36 YHVNHLVTFCLGEEDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPGHVTLLDPVSKEELESYP 100

  Fly   111 GSLITEPTAFISDHPQESFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVEDL----------- 164
            ...|....|.:   |:....::|:...........::|.||...:.:.|:.||:
  Rat   101 LDAIVRCDAVM---PRGRSRSLLLLVCQEPERAQPDVHFFQGLLLGAELIREDIQGALQNYRSGR 162

  Fly   165 ------------KTLSKGTPVTVDRNKTPILLPKPE---------------RPQ------NQQAK 196
                        :.|.:|.....:   ||.|..:|.               |||      .::|:
  Rat   163 GERRAAALRATQEELRRGASPAAE---TPPLQRRPSVRAVINTVEPSAVRGRPQVEPIPETEEAR 224

  Fly   197 -----------------DQYGIAAAVAGIAAEKNAIDKEQTERDVQVINHCFEDIERFMARLHYA 244
                             |.......:||:          |.||||.::||.|:|:|.|::||..:
  Rat   225 KPDPARTTTRSSDPTSPDLGPRGPELAGL----------QAERDVDILNHVFDDVESFVSRLQKS 279

  Fly   245 AEALNEL----KLRKEQHNPHGEGLLVLRSRPPIESEFHDILAKAKLALIYSVRLQNQFTKPADP 305
            |||...|    :.|:.:....|||||.||::||.|:|:.|:|.|.|.|.....||:.....|:.|
  Rat   280 AEATRVLEHRERGRRTRRRAAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARLRGNIANPSSP 344

  Fly   306 --VHNVFISLKSIVTVCNDIYVDAGLPQAVLNPLLRRETIAFLNGTLDSNEMQLWQSLGPNWTVP 368
              :|.:|..|:.||....    ....|::|..|.|..|.:|.|...:...|.:||.|||.:||.|
  Rat   345 ELLHFLFGPLQMIVNTSG----GPEFPRSVRRPHLTLEAVALLRDNVTPRENELWTSLGDSWTRP 405

  Fly   369 KDQFKDHKSS-YHPIFYDDWSPDWVVDEEVPYLAPALK--------KSTTPSPVPVPMPPSPGLG 424
            ..:....:.| |.|.||..|.|.....:..|:..|..|        :..:...|.|.....|.|.
  Rat   406 GVELPPEEGSPYSPEFYSGWEPPATDPQGRPWEDPVEKQLQHEKRRRQQSAPQVAVNGHQDPELE 470

  Fly   425 NRTWLSRLESRNVKIAEVTFNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVL 489
            ..   |:||.:..|.....::..|.|..||.|...:.||::||.|.|||.|:..|..||||:.:|
  Rat   471 TE---SQLEEKARKWVLCNYDFQARNGSELSVKHRDVLEVLDDRRKWWKVRDHQGQEGYVPYNIL 532

  Fly   490 TPYNFEPGVNGRDTESLASMALTENGGEEAIPPPLYRNTMAMYTAPVEQPAANGKAMQRTFSMPN 554
            ||:   ||.....::|                                             |..|
  Rat   533 TPH---PGPQVHCSQS---------------------------------------------SAIN 549

  Fly   555 VPVPPPMPPPSDSQTPTPSGTLKRNMAAAGALAAMRARND-CE-------ADDQLYYMQGDVHDE 611
            :...||.|||                |||.|...:|.:.| |:       :|.:.:.....|::|
  Rat   550 LETSPPPPPP----------------AAAPAPTQVRPQWDSCDSLNSLDPSDKEKFSQMLCVNEE 598

  Fly   612 L--RLLQQQRERRKDLEILKTPEIFITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSP 674
            |  ||.|.:....:....|:.||..::..|:.|.|..||:.||||...:..|..|:|.::|:|..
  Rat   599 LQARLAQGRSGPSRVTPGLRAPEPQLSPRSEASVVRAWLQTKGFSSGTVDALGVLTGAQLFSLQK 663

  Fly   675 HTIESYFGRRESRRLISQIVLQKNFCEYKTIRSSELSAKLARARQKAD 722
            ..:.|.. ..|..|:.||:.:|:...|.:. :.|||.|.:.:.::|.:
  Rat   664 EELRSVC-PEEGARVYSQVTVQRALLEDRE-KVSELEAVMEKQKKKVE 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	30/151 (20%)
		SH3_Eps8	439..492	CDD:212698	21/52 (40%)
		SAM_3	630..693	CDD:436214	20/62 (32%)
Eps8l1	NP_001101937.1	PTB_EPS8	32..162	CDD:269921	28/128 (22%)
		SH3_Eps8	482..534	CDD:212698	20/51 (39%)
		SAM_EPS8-like	623..688	CDD:188939	20/65 (31%)