DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8907 and Eps8

DIOPT Version :9

Sequence 1:	NP_001247146.1	Gene:	CG8907 / 42050	FlyBaseID:	FBgn0038466	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001363864.1	Gene:	Eps8 / 312812	RGDID:	1310590	Length:	822	Species:	Rattus norvegicus

Alignment Length:	841	Identity:	224/841 - (26%)
Similarity:	357/841 - (42%)	Gaps:	191/841 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YGMPQNGYENGVPGGNQANGH---------YDEVK-------------PTYALEHLATFKLKNEA 61
            |....|||.:..|.......|         |::.|             ..|.:|||.||.|..:.
  Rat    15 YPSQMNGYGSSPPYSQMDREHCSRTSAKALYEQRKNYARDSVSSVSDVSQYRVEHLTTFVLDRKD 79

  Fly    62 EVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDMK-EIENFPGSLITEPTAFISDHP 125
            .:....:.::.|..|:..|.:|...|.:..:.:.:.::|.:.| |:||||.:.|        .|.
  Rat    80 AMITVDDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTI--------QHC 136

  Fly   126 QE-----SFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVEDLKTL---SKGTPVTVDRNKTPI 182
            |.     |:::||.......:....::|:||..:|.:.|:.||:::.   |||.    .:.:.|.
  Rat   137 QAVAHTCSYDSILALVCKEPTQNKPDLHLFQCDEVKANLISEDIESAISDSKGG----KQKRRPE 197

  Fly   183 LL----------------PKPERPQNQQAKDQYGIAAAVAGIAAEKNAIDK-------EQT---- 220
            .|                |.|..|......|.....||.:..||::...:|       |:|
  Rat   198 ALRMIAKADPGIPPPPRAPAPVPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMM 262

  Fly   221 ----ERDVQVINHCFEDIERFMARLHYAAEALNEL----KLRKEQHNPHGEGLLVLRSRPPIESE 277
                :||||::||..:|||.|:.:|..||||.:||    |.:|.:....|||:|.||::||...|
  Rat   263 AARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKSKKSKRKGPGEGVLTLRAKPPPPDE 327

  Fly   278 FHDILAKAKLALIYSVRLQNQFTKP--ADPVHNVFISLKSIVTVCNDIYVDAGLPQ---AVLNPL 337
            |.|...|.|.......:|::....|  :|.||.:|..|..:|..       .|.|:   :||:||
  Rat   328 FVDCFQKFKHGFNLLAKLKSHIQNPSASDLVHFLFTPLNMVVQA-------TGGPELASSVLSPL 385

  Fly   338 LRRETIAFLNGTLDSNEMQLWQSLGPNWTV-----PKDQFKDHKSSYHPIFYDDWSPDWV----- 392
            |.::|:.|||.|:.:.|.|||.|||..|..     ||:||   ...|.|.|.:.|.|..:
  Rat   386 LTKDTVDFLNYTVKAEERQLWMSLGETWMKVRAEWPKEQF---IPPYVPRFRNGWEPPMLNFMGA 447

  Fly   393 -VDEEVPYLAPAL------------KKSTTPSPVPVPMPPSPG--------------------LG 424
             .::::..||.::            |:.:|........||:.|                    |.
  Rat   448 PTEQDMYQLAESVANAAEQQRKQDSKRQSTEHSSMSDYPPADGYTFSNSMYHRGPHVDQGEAALA 512

  Fly   425 NRTWLSRLESRNV--------KIAEVTFNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNI 481
            .::..:|...||.        |.|:..::..|.|..||.|.|.:.|||:||.:.|||.||:.|:.
  Rat   513 LKSTPNRHVDRNYDPVKTQPKKYAKSKYDFVARNSSELSVMKDDVLEILDDRKQWWKVRNASGDS 577

  Fly   482 GYVPHTVL----TPYNFEPGVNGRD---TESLASMALTENGGEEAIPPPLYRNTMAMYTAPVEQP 539
            |:||:.:|    ||   |.||...|   |.::.... ||.|...|..|          :||...|
  Rat   578 GFVPNNILDIMRTP---ESGVGRTDPPYTHTIQKQR-TEYGPRSADTP----------SAPSPPP 628

  Fly   540 AANGKAMQRTFSMPNVPVPPPMPPPSDSQTP---TPSGTLKRNMAAA---GALAAMRAR-NDCEA 597
            ..             .|||.|:||.:.:..|   .|:...::|.:::   |::|....| .....
  Rat   629 TP-------------APVPVPLPPSAPAPVPVPKVPANVTRQNSSSSESGGSIARDSQRYKQLPV 680

  Fly   598 D---DQLYYMQGDVHDELRLLQQQRERRKDLEILKTPEIFITQNSKPSEVEEWLRGKGFSDIIIK 659
            |   .|:..:|.::...|.:.:...:|:..:.....|.|.||.:|.|.||:.||:.|||:.:.:.
  Rat   681 DRRKSQMEEVQDELFQRLTIGRSAAQRKFHVPRQNVPVINITYDSSPEEVKTWLQSKGFNPVTVS 745

  Fly   660 RLHTLSGEEIFALSPHTIESYFGRRESRRLISQIVLQKNFCEYKTIRSSELSAKLARARQK 720
            .|..|:|.::|:|:...:.|..  .|..|:.|||.:||...| .:..||||...:.|.::|
  Rat   746 SLGVLNGAQLFSLNKDELRSVC--PEGARVFSQITVQKAALE-DSSGSSELQEIMRRRQEK 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	36/153 (24%)
		SH3_Eps8	439..492	CDD:212698	23/56 (41%)
		SAM_superfamily	635..699	CDD:301707	24/63 (38%)
Eps8	NP_001363864.1	PTB_EPS8	64..191	CDD:269921	35/138 (25%)
		SH3_Eps8	535..588	CDD:212698	22/52 (42%)
		Effector region. /evidence=ECO:0000250	649..822		43/158 (27%)
		Amphipathic helix. /evidence=ECO:0000250	680..698		3/17 (18%)
		Helix bundle 1. /evidence=ECO:0000250	718..738		9/19 (47%)
		SAM_EPS8-like	720..784	CDD:188939	24/65 (37%)
		Helix bundle 2. /evidence=ECO:0000250	752..757		1/4 (25%)
		Helix bundle 3. /evidence=ECO:0000250	762..767		1/4 (25%)
		Helix bundle 4. /evidence=ECO:0000250	766..785		7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5805
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	1	1.000	-	-		otm46369
orthoMCL	1	0.900	-	-		OOG6_106655
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.920