DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8907 and Eps8l3

DIOPT Version :9

Sequence 1:	NP_001247146.1	Gene:	CG8907 / 42050	FlyBaseID:	FBgn0038466	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	NP_001099933.1	Gene:	Eps8l3 / 295361	RGDID:	1308310	Length:	600	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	167/745 - (22%)
Similarity:	259/745 - (34%)	Gaps:	269/745 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KPT---YALEHLATFKLKNEAEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDMKE 105
            :||   :.:|||.|.||..: .|::||:.::.|.|::..|.:|...:|:.....||.:||.:.||
  Rat    23 EPTLLQHRVEHLMTCKLGTQ-RVREPKDALQKLQEMDAQGRVWSQNLFLQVKDGWLQLLDIETKE 86

  Fly   106 ------IENFPGSLITEPTAFISDHPQESFNNILIFSV-----PGISLGNTEMHIFQVADVSSVL 159
                  ::|.....:...|.        |:::||..:|     ||||     ..:||..:|.:..
  Rat    87 DLDSYRLDNIKAIDVALNTC--------SYDSILSVTVQESGLPGIS-----TMLFQCQEVGAEQ 138

  Fly   160 LVEDL-KTLS-------------------KGTPV--TVDRNKTPILLPK--------PERPQ--- 191
            |...| |.|.                   ||:|:  .:..::.|.|..:        ||||.
  Rat   139 LRTSLQKALEEELEERPRFGVHHPGQDRWKGSPLQRPIPIHQAPPLEQRFSPEPRFPPERPHDMT 203

  Fly   192 -------NQQAKDQYGIAAAVAGIA---AEKNAIDKEQTERDVQVINHCFEDIERFMARLH--YA 244
                   :.::...|..|....|..   ..:.|...|..|||.:|:||...|||.|..:|.  .|
  Rat   204 PERSITPSSRSLTHYPSAREPNGFTLPPPPRRAPSPENPERDEEVLNHVLRDIELFSGKLKEIQA 268

  Fly   245 AEALNELKLRKEQHNPHGEGLLVLRSRPPIESEFHDILAKAKLA--LIYSVRLQNQFTKPADPVH 307
            ..:..::||.:::.....|         ..::::.|...|.|.:  |:..:.|:.|.|...:.|.
  Rat   269 KNSHKKIKLGRKKKKYQKE---------ITQAQYIDCFQKIKFSFNLLGKLALRLQETSAPEFVG 324

  Fly   308 NVFISLKSIVTVCNDIYVDAGLPQAVLNPLLRRETIAFLNGTLDSNEMQLWQSLGPNWTVP-KDQ 371
            .:|.:|:.|::.|    .:|.|...|::|||..:.|..|...|...|..||:|||..||.. .|.
  Rat   325 LIFQTLRFILSQC----PEADLTTKVISPLLTPKAIDLLQSCLSPPERTLWKSLGTAWTTSWADW 385

  Fly   372 FKDHKSSYHPIFYDDWS-PDWVVDEEVPYLAPALKKSTT--------------PSPVP------- 414
            .......|.|.|||.|. |:       ||....|:...:              |...|
  Rat   386 TGSEPPPYQPTFYDGWQIPE-------PYSTKPLRNQDSLSLRGSRMRSSLHFPQDEPYNDSREY 443

  Fly   415 ----VPMP-PSPGLGNRTWLSRLESRNVKIAEVTFNKSATNDKELKVTKGEYLEIIDDSRNWWKA 474
                :|:| |||   :||.|.         .:|.:...|.|.:||.|.:||.|||:|.|:.||..
  Rat   444 EDSNLPLPSPSP---DRTALK---------MQVLYEFEARNAQELTVAQGEILEILDQSKRWWLV 496

  Fly   475 RNSYGNIGYVPHTVLTPYNFEPGVNGRDTESLASMALTENGGEEAIPPPLYRNTMAMYTAPVEQP 539
            :|..|..||:|..:|.|                                          .|...|
  Rat   497 KNEAGLTGYIPSNILEP------------------------------------------LPAGAP 519

  Fly   540 AANGKAMQRTFSMPNVPVPPPMPPPSDSQTPTPSGTLKRNMAAAGALAAMRARNDCEADDQLYYM 604
            ..:   .|.:|..|
  Rat   520 RGH---RQSSFRAP--------------------------------------------------- 530

  Fly   605 QGDVHDELRLLQQQRERRKDLEILKTPEIFITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGE-- 667
                  .|||                       :|||.||..||:.:.||.:.::.|.:|.|.
  Rat   531 ------MLRL-----------------------SSKPEEVTAWLQAENFSTVTVRTLGSLVGSQL 566

  Fly   668 ------EIFALSPHTIESYFGRRES-RRLI 690
                  |:..|.|........|.|: ||::
  Rat   567 LHMRLGELQMLCPQEAPRIQARLEAVRRML 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	42/166 (25%)
		SH3_Eps8	439..492	CDD:212698	21/52 (40%)
		SAM_superfamily	635..699	CDD:301707	19/65 (29%)
Eps8l3	NP_001099933.1	PTB_EPS8	25..146	CDD:269921	36/134 (27%)
		SH3_Eps8	462..514	CDD:212698	22/93 (24%)
		SAM_superfamily	531..596	CDD:301707	22/87 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345254
Domainoid	1	1.000	64	1.000	Domainoid score	I9866
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46369
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950