DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8907 and EPS8

DIOPT Version :9

Sequence 1:	NP_001247146.1	Gene:	CG8907 / 42050	FlyBaseID:	FBgn0038466	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_011518907.1	Gene:	EPS8 / 2059	HGNCID:	3420	Length:	842	Species:	Homo sapiens

Alignment Length:	833	Identity:	219/833 - (26%)
Similarity:	355/833 - (42%)	Gaps:	175/833 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YGMPQNGY-----------ENGVPGGNQANGHYDEVK-------------PTYALEHLATFKLKN 59
            |....|||           |:|  ....|...|::.|             ..|.:|||.||.|..
Human    35 YPSQMNGYGSSPTFSQTDREHG--SKTSAKALYEQRKNYARDSVSSVSDISQYRVEHLTTFVLDR 97

  Fly    60 EAEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDMK-EIENFPGSLITEPTAFISD 123
            :..:....:.::.|..|:..|.:|...|.:..:.:.:.::|.:.| |:||||.:.|....|.:..
Human    98 KDAMITVDDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHS 162

  Fly   124 HPQESFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVEDLKTL---SKG-------TPVTVDRN 178
            .   |::::|.......:....::|:||..:|.:.|:.||:::.   |||       ..:.:..|
Human   163 C---SYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKRRPDALRMISN 224

  Fly   179 KTPILLPKPERPQ-----NQQAKDQYGIAAAVAGIAAEKNAIDK-------EQT--------ERD 223
            ..|.:.|.|..|.     .....|.....||.:..||::...:|       |:|        :||
Human   225 ADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRD 289

  Fly   224 VQVINHCFEDIERFMARLHYAAEALNELKLRKE----QHNPHGEGLLVLRSRPPIESEFHDILAK 284
            ||::||..:|||.|:.:|..||||.:||..||:    :....|||:|.||::||...||.|...|
Human   290 VQILNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQK 354

  Fly   285 AKLALIYSVRLQNQFTKP--ADPVHNVFISLKSIVTVCNDIYVDAGLPQ---AVLNPLLRRETIA 344
            .|.......:|::....|  ||.||.:|..|..:|..       .|.|:   :||:|||.::||.
Human   355 FKHGFNLLAKLKSHIQNPSAADLVHFLFTPLNMVVQA-------TGGPELASSVLSPLLNKDTID 412

  Fly   345 FLNGTLDSNEMQLWQSLGPNWTV-----PKDQFKDHKSSYHPIFYDDWSPDWV------VDEEVP 398
            |||.|::.:|.|||.|||..|..     ||:||   ...|.|.|.:.|.|..:      :::::.
Human   413 FLNYTVNGDERQLWMSLGGTWMKARAEWPKEQF---IPPYVPRFRNGWEPPMLNFMGATMEQDLY 474

  Fly   399 YLAPA------------LKKSTTPSPVPVPMPPSPG-------------------------LGNR 426
            .||.:            :|:.:|.........|:.|                         ..||
Human   475 QLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNR 539

  Fly   427 TWLSR----LESRNVKIAEVTFNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHT 487
             .:.|    |:::..|.|:..::..|.|:.||.|.|.:.|||:||.:.|||.||:.|:.|:||:.
Human   540 -HIDRNYEPLKTQPKKYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNN 603

  Fly   488 VLTPYNFEPGVNGRDTESLASMALTENGGEEAIPP---PLYRNTMAMYTAPVEQPAANGKAMQRT 549
            :|.                 .:...|:|...|.||   .:.:..|.....|.:.|.|.
Human   604 ILD-----------------IVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAP------- 644

  Fly   550 FSMPNVPVPPPMPPPSDSQTPTPSGTLKRNMA--------AAGALAAMRARNDCEADDQLYYMQG 606
             |.|..|.|.|:|.|..:..|.|...:..|:.        :.|::.....|:.....|:......
Human   645 -SPPPTPAPVPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQME 708

  Fly   607 DVHDEL--RLLQQQRERRKDLEILK--TPEIFITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGE 667
            :|.|||  ||...:...:|...:.:  .|.|.||.:|.|.:|:.||:.|||:.:.:..|..|:|.
Human   709 EVQDELIHRLTIGRSAAQKKFHVPRQNVPVINITYDSTPEDVKTWLQSKGFNPVTVNSLGVLNGA 773

  Fly   668 EIFALSPHTIESYFGRRESRRLISQIVLQKNFCEYKTIRSSELSAKLARARQK 720
            ::|:|:...:.:..  .|..|:.|||.:||...| .:..||||...:.|.::|
Human   774 QLFSLNKDELRTVC--PEGARVYSQITVQKAALE-DSSGSSELQEIMRRRQEK 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	34/155 (22%)
		SH3_Eps8	439..492	CDD:212698	22/52 (42%)
		SAM_superfamily	635..699	CDD:301707	22/63 (35%)
EPS8	XP_011518907.1	PTB_EPS8	84..211	CDD:269921	33/129 (26%)
		SH3_Eps8	555..608	CDD:212698	22/69 (32%)
		SAM_EPS8-like	740..804	CDD:188939	22/65 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5844
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	1	1.000	-	-		otm42216
orthoMCL	1	0.900	-	-		OOG6_106655
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4036
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.850