Protein Alignment CG8907 and Eps8

DIOPT Version :10

• Sequence 1: NP_001247146.1
• Gene: CG8907 / 42050
• FlyBaseID: FBgn0038466
• Length: 732
• Species: Drosophila melanogaster
• Sequence 2: NP_001258516.1
• Gene: Eps8 / 13860
• MGIID: 104684
• Length: 847
• Species: Mus musculus
• Alignment Length: 859
• Identity: 226/859 - (26%)
• Similarity: 367/859 - (42%)
• Gaps: 193/859 - (22%)

  Fly     2 VKAG------NRTLKYFRPISVKYGMPQNGYENGVPGGNQANGH---------YDEVK------- 44
            |:||      ||:..|     ..|....|||.:..|.......|         |::.|
Mouse    23 VRAGMNGHMSNRSSGY-----GVYPSQLNGYGSSPPYSQMDREHSSRTSAKALYEQRKNYARDSV 82

  Fly    45 ------PTYALEHLATFKLKNEAEVKQPKEKMKLLVELEKTGGIWPHKMFMSFNGQWLVMLDSDM 103
                  ..|.:|||.||.|..:..:...::.::.|..|:..|.:|...|.:..:.:.:.::|.:.
Mouse    83 SSVSDVSQYRVEHLTTFVLDRKDAMITVEDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLES 147

  Fly   104 K-EIENFPGSLITEPTAFISDHPQESFNNILIFSVPGISLGNTEMHIFQVADVSSVLLVEDLKTL 167
            | |:||||.:.|:...|.:  |.. |:::||.......:....::|:||..:|.:.|:.||:::.
Mouse   148 KNELENFPLNTISHCQAVV--HAC-SYDSILALVCKEPTQSKPDLHLFQCDEVKANLISEDIESA 209

  Fly   168 ---SKGTPVTVDRNKTPILL----------------PKPERPQNQQAKDQYGIAAAVAGIAAEKN 213
               |||.    .:.:.|..|                |.|..|......|.....||.:..||::.
Mouse   210 ISDSKGG----KQKRRPEALRMIAKADPGIPPPPRAPAPVPPGTVTQVDVRSRVAAWSAWAADQG 270

  Fly   214 AIDK-------EQT--------ERDVQVINHCFEDIERFMARLHYAAEALNEL----KLRKEQHN 259
            ..:|       |:|        :||||::||..:|||.|:.:|..||||.:||    |.:|.:..
Mouse   271 DFEKPRQYHEQEETPEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKSKKSKRK 335

  Fly   260 PHGEGLLVLRSRPPIESEFHDILAKAKLALIYSVRLQNQFTKP--ADPVHNVFISLKSIVTVCND 322
            ..|||:|.||::||...||.|...|.|.......:|::....|  :|.||.:|..|..:|..
Mouse   336 GPGEGVLTLRAKPPPPDEFVDCFQKFKHGFNLLAKLKSHIQNPSASDLVHFLFTPLNMVVQA--- 397

  Fly   323 IYVDAGLPQ---AVLNPLLRRETIAFLNGTLDSNEMQLWQSLGPNWTV-----PKDQFKDHKSSY 379
                .|.|:   :||:|||.::|:.|||.|..:.|.:||.|||.:|..     ||:||   ...|
Mouse   398 ----TGGPELASSVLSPLLTKDTVDFLNYTATAEERKLWMSLGDSWVKVRAEWPKEQF---IPPY 455

  Fly   380 HPIFYDDWSPDWV------VDEEVPYLAPAL-----------KKSTTPSPVPVPMPPSPGLG--- 424
            .|.|.:.|.|..:      .::::..||.::           |:.:|........||:.|..
Mouse   456 VPRFRNGWEPPMLNFMGAPTEQDMYQLAESVANAEHQRKQDSKRLSTEHSNVSDYPPADGYAYSS 520

  Fly   425 --------------------------NRTWLSRLESRNVKIAEVTFNKSATNDKELKVTKGEYLE 463
                                      :|.: ..::::..|.|:..::..|.|..||.|.|.:.||
Mouse   521 SMYHRGPHADHGEAAMPFKSTPNHQVDRNY-DAVKTQPKKYAKSKYDFVARNSSELSVMKDDVLE 584

  Fly   464 IIDDSRNWWKARNSYGNIGYVPHTVL----TPYNFEPGVNGRD---TESLASMALTENGGEEAIP 521
            |:||.|.|||.||:.|:.|:||:.:|    ||   |.||...|   |.::.... ||.|...|..
Mouse   585 ILDDRRQWWKVRNASGDSGFVPNNILDIMRTP---ESGVGRADPPYTHTIQKQR-TEYGLRSADT 645

  Fly   522 PPLYRNTMAMYTAPVEQPAANGKAMQRTFSMPNVPVPPPMPP--PSDSQTP-TPSGTLKRNMAAA 583
            |          :||...|..             .|||.|:||  |:....| .|:...::|.:::
Mouse   646 P----------SAPSPPPTP-------------APVPVPLPPSVPAPVSVPKVPANVTRQNSSSS 687

  Fly   584 ---GALAAMRAR-NDCEAD---DQLYYMQGDVHDELRLLQQQRERRKDLEILKTPEIFITQNSKP 641
               |::.....| .....|   .|:..:|.::...|.:.:...:|:..:.....|.|.||.:|.|
Mouse   688 DSGGSIVRDSQRYKQLPVDRRKSQMEEVQDELFQRLTIGRSAAQRKFHVPRQNVPVINITYDSSP 752

  Fly   642 SEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHTIESYFGRRESRRLISQIVLQKNFCEYKTIR 706
            .||:.||:.|||:.:.:..|..|:|.::|:|:...:.|..  .|..|:.:||.:||...| .:..
Mouse   753 EEVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRSVC--PEGARVFNQITVQKAALE-DSNG 814

  Fly   707 SSELSAKLARARQK 720
            ||||...:.|.::|
Mouse   815 SSELQEIMRRRQEK 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	36/148 (24%)
		SH3_Eps8	439..492	CDD:212698	24/56 (43%)
		SAM_3	630..693	CDD:436214	21/62 (34%)
Eps8	NP_001258516.1	PTB_EPS8	90..217	CDD:269921	35/133 (26%)
		SH3_Eps8	560..613	CDD:212698	23/52 (44%)
		SAM_EPS8-like	745..809	CDD:188939	23/65 (35%)