DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8907 and eps8l1

DIOPT Version :9

Sequence 1:	NP_001247146.1	Gene:	CG8907 / 42050	FlyBaseID:	FBgn0038466	Length:	732	Species:	Drosophila melanogaster
Sequence 2:	XP_004916293.1	Gene:	eps8l1 / 100494819	XenbaseID:	XB-GENE-991373	Length:	751	Species:	Xenopus tropicalis

Alignment Length:	826	Identity:	212/826 - (25%)
Similarity:	340/826 - (41%)	Gaps:	214/826 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NGVPGGNQANGHYDEVK----------PTYALEHLATFKLKNEAEVKQPKEKMKLLVELEKTGGI 82
            |||...| |...|::.|          ..|.:.||.||.:..:.:|...::.::.|..::..|.|
Frog     8 NGVSKPN-AKSIYEQRKKYSNVIMADVSQYQVHHLVTFTIGEDDDVHTVEDAIRKLNAVDSKGKI 71

  Fly    83 WPHKMFMSFNGQWLVMLDSDMK-EIENFPGSLITEPTAFISDHPQESFNNILIFSVPGISLGNTE 146
            |..:|.:..|...:.::|.:.| |:|.||.|.|......:   |:...:.:||...........:
Frog    72 WIQEMLIEVNSSVVKLVDVNSKEELEEFPLSAIQRCDTVL---PERRNHPLLILVCQDTYQPKPD 133

  Fly   147 MHIFQVADVSSVLLVEDLKT-----------------------LSKG------------------ 170
            ::.||...|::.|:.||:.:                       :::|
Frog   134 VYFFQSDYVAAHLIKEDINSAVSDFQSGVNAKRPEALRNNMEQIAQGAPGPNTFTPLGQWRQPTS 198

  Fly   171 ---TPVTV---DRNKTPILLP---------------------KPERPQN------------QQAK 196
               ||..:   :..:.|::.|                     .|:.||.            ||..
Frog   199 QYVTPAEILEREAQRKPMVKPPRSSLTKIIVSSTDQGQQSIETPQYPQEPLYSEIKRHDKPQQFV 263

  Fly   197 DQYGI------AAAVAGIAA-EKNAIDKEQTERDVQVINHCFEDIERFMARLHYAAEALNELKLR 254
            .:.|.      ...|.|.|| :.:|:   ::..:|.::||||:|||.||..|..:|||...|..|
Frog   264 QESGSPQLQQKTLKVPGEAATDPSAV---RSGHEVDLLNHCFDDIEFFMGSLQKSAEAFKMLNQR 325

  Fly   255 KEQHNPH----GEGLLVLRSRPPIESEFHDILAKAKLALIYSVRLQNQFTKPA--DPVHNVFISL 313
            |:.....    |||||.||::||...|:.|.:.|.|.......||:|....|:  :.||.:|..|
Frog   326 KKSRRTKKKEAGEGLLTLRAKPPRIEEYEDAVRKFKYCFCLLARLRNNIVNPSAIELVHFLFGPL 390

  Fly   314 KSIVTVCNDIYVDAGLPQAVLNPLLRRETIAFLNGTLDSNEMQLWQSLGPNWTVPKDQF-KDHKS 377
            :::|..|..:    .:|..:..|||..|.:.||..:|:..|::||.|||||||.|:.:: |:...
Frog   391 RTLVDSCGGV----EMPAEITTPLLTNEAVTFLKESLNEQELELWTSLGPNWTKPRLEYPKEFCQ 451

  Fly   378 SYHPIFYDDWSP------DWVVDEEVPYLAPALK--KSTTPSPVPVPMPPSPGLGNRTWLSRLES 434
            .|.|.|...|.|      .|....|:.:....|:  :|.....:|.|:|...|         .|.
Frog   452 PYTPTFRSGWVPVSTNGKPWEDPIELQHRHEELRAQQSAPQVNIPAPIPAVNG---------HEE 507

  Fly   435 RNVKIAEVTFNKSATNDKELKVTKGEYLEIIDDSRNWWKARNSYGNIGYVPHTVLTPYNFEPGVN 499
            .:.|....|::..|.|..||.|..||.||:||||:.|||.:|.:|.|||||:.:|.||
Frog   508 TDAKRVSCTYDFVARNSSELSVLHGEVLEVIDDSKKWWKVQNRFGQIGYVPYNILAPY------- 565

  Fly   500 GRDTESLASMALTENGGEEAIPPPLYRNTMAMYTAPVEQPAANGKAMQRTFSMPNVPVPPPMPPP 564
               |.:.|:.| ..||.:::.|.                                 .||||.||.
Frog   566 ---TATDANKA-NVNGSQQSSPS---------------------------------KVPPPKPPK 593

  Fly   565 SDSQTPTPSGTLKRN------------MAAAGALAAMRARNDCEADDQLYYMQGDVHDELRLLQQ 617
            .      ||..:.||            :...|.:..:.:.|     ::|.         |||...
Frog   594 K------PSNGIARNSWDQSNGLNQEQITEQGKMERISSMN-----EELL---------LRLANG 638

  Fly   618 QRERRKDLEILKTPE--IFITQNSKPSEVEEWLRGKGFSDIIIKRLHTLSGEEIFALSPHTIESY 680
            :...:|:|.|.|.|:  |.:|..|.|:||..||:.|||:.:.:..|..|:|.::|:|......:.
Frog   639 RTAPQKNLNIQKMPDTSIPLTDESSPAEVTAWLQAKGFNTLTVNSLGVLNGVQLFSLRKDEFRAV 703

  Fly   681 FGRRESRRLISQIVLQKNFCEYKTIRSSELSAKLARARQKADQSNG 726
            . ..|..|:.||:::||...| .:.:.|||.|.:.|.:::.| :||
Frog   704 C-PEEGARVYSQVMVQKALLE-DSKKISELEAVMERQKKRVD-TNG 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8907	NP_001247146.1	PTB_EPS8	43..175	CDD:269921	33/186 (18%)
		SH3_Eps8	439..492	CDD:212698	25/52 (48%)
		SAM_superfamily	635..699	CDD:301707	21/63 (33%)
eps8l1	XP_004916293.1	PTB_EPS8	32..162	CDD:269921	29/132 (22%)
		SH3_Eps8	513..565	CDD:212698	25/51 (49%)
		SAM_EPS8-like	657..722	CDD:188939	21/65 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5627
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2834
OMA	1	1.010	-	-		QHG47799
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	1	1.000	-	-		otm49446
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080