Protein Alignment MEF2A and mef-2

DIOPT Version :10

• Sequence 1: NP_001386957.1
• Gene: MEF2A / 4205
• HGNCID: 6993
• Length: 543
• Species: Homo sapiens
• Sequence 2: NP_492441.1
• Gene: mef-2 / 172732
• WormBaseID: WBGene00003182
• Length: 340
• Species: Caenorhabditis elegans
• Alignment Length: 477
• Identity: 163/477 - (34%)
• Similarity: 207/477 - (43%)
• Gaps: 158/477 - (33%)

Human     1 MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKV 65
            |||||||||||.||||||||||||||||||||||||||||||||||:|||:||||||||||||||
 Worm     1 MGRKKIQITRIQDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIVFNSTNKLFQYASTDMDKV 65

Human    66 LLKYTEYNEPHESRTNSDIVETL-RKKGLNGCESPDADDYFEHSPLSEDRFSKLNEDSDFIFKRG 129
            ||||||||||||||||:||:|.| ||:|..|  ..::||
 Worm    66 LLKYTEYNEPHESRTNNDIMEALNRKEGNQG--GGNSDD-------------------------- 102

Human   130 PALNKKEHRGCDSPDPDTSYVL---TPHTEEKYKKINEEFDNMMRNHKIAPGLPPQNFSMSVTVP 191
                       :||.|.||.|:   .|.....:..          |:.:|......  :.:|...
 Worm   103 -----------ESPGPSTSPVIQITMPAVVNGHSS----------NNSVASAASAS--AAAVAAA 144

Human   192 VTSPNALSYTNPGSSLVSPSLAASSTLTD------SSMLSPPQTTLHRNVSPGAPQRPPSTGNAG 250
            ..:..|:..|:.|::..:.:|.||:....      .:::..|..|.|.|      ||       .
 Worm   145 AAAVAAVEGTSSGAAAAAAALQASNAQRHHNLNLYQNLIFNPNYTRHLN------QR-------N 196

Human   251 GMLSTTDLTVPNGAGSS----PVGNGFV--NSRASPNLIGATGANSLGKVMPTKSPPPPGGGNLG 309
            ..||:|.: .|:.:.|.    |....|.  .||..|  |.|..|:.
 Worm   197 DPLSSTSV-APSSSSSKHLDFPPSTSFAYDTSRLHP--IAAADADC------------------- 239

Human   310 MNSRKPDLRVVIPPSSKGMMPPLNTQRISSSQATQ-PLATPVVSVTTPSLPPQGLVYSAMPTAYN 373
                  ||    .|||:...    .|.|.||...| |::.|..|::..|  ..|:        .|
 Worm   240 ------DL----VPSSRAAA----DQNIWSSALQQRPVSQPAPSISNSS--TNGI--------SN 280

Human   374 TDYSLTSADLSALQGFNSPGMLSLGQVSAWQQHHLGQAALSSLVAGGQLSQGSNLSINTNQNISI 438
            ...||.|.::|:|.|.:   :|.||                          |.||....:.|..:
 Worm   281 GTSSLLSPNVSSLNGHS---VLDLG--------------------------GPNLPYKLDPNTYV 316

Human   439 KSEPISPP--RDRMTPSGFQQQ 458
            |.||.|||  |.|:|.....||
 Worm   317 KMEPHSPPEKRPRITTEWRPQQ 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MEF2A	NP_001386957.1	ARG80	1..280	CDD:227400	119/294 (40%)
		MADS_MEF2_like	2..78	CDD:238165	72/75 (96%)
		HJURP_C	141..198	CDD:463543	10/59 (17%)
mef-2	NP_492441.1	MADS_MEF2_like	2..78	CDD:238165	72/75 (96%)