Protein Alignment Irc and Duox1

DIOPT Version :10

• Sequence 1: NP_650584.1
• Gene: Irc / 42049
• FlyBaseID: FBgn0038465
• Length: 697
• Species: Drosophila melanogaster
• Sequence 2: NP_001092767.1
• Gene: Duox1 / 99439
• MGIID: 2139422
• Length: 1551
• Species: Mus musculus
• Alignment Length: 585
• Identity: 163/585 - (27%)
• Similarity: 245/585 - (41%)
• Gaps: 108/585 - (18%)

  Fly   142 NSLKGNREGHYAFR--RLLGSSHYRNGFYQMFPNSGRRETVPAAWSISKELYEPDHIQISK---- 200
            |:|..:|.|....|  ||:.:| |.:|.||..                ||.|.|:...:|.
Mouse    37 NNLMEHRWGSKGSRLQRLVPAS-YADGVYQPL----------------KEPYLPNPRHLSNRVMR 84

  Fly   201 ----QQTFESNSNLALPQWAQFVEHDLSKPVSQSMSNGAPIECCSRDQINLQPRHHHPACAPILY 261
                |.:..:.:.|.:    .|..|.||..||.. :.|.|.|.     :|:...|..|     ::
Mouse    85 GSAGQPSLRNRTVLGV----FFGYHVLSDLVSVE-TPGCPAEF-----LNIYIPHGDP-----VF 134

  Fly   262 QPGGKYDVPSCLNYVRSALAVADCNFGGA-----EQLNQATGSLDLSQLYGFTAAAERKLRVLEG 321
            .|..:.:|  .|.:.||..   |.|.|.:     :|.||.||.||.|.:||.:.:....||...|
Mouse   135 DPDKRGNV--VLPFQRSRW---DRNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSG 194

  Fly   322 GLLRSTPRGEF-----DNALLPIATDTEGPSFCARATIGDG---TCFAAGDSRVNSSPFSILIYT 378
            |.|.|.|...|     .:.|:.:|.|   ||      .|.|   ..:|.|..|.|..||...:..
Mouse   195 GQLASGPDPAFPSDSQSSLLMWMAPD---PS------TGQGGPRGVYAFGAQRGNREPFLQALGL 250

  Fly   379 IFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQPNR 443
            ::.|.||..|.:|.|.:|.|.||:|||.|:...:..|:.:.:.||||..|.| ...|....:|..
Mouse   251 LWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIAMYEWLPSFLKQ-TPPEYPGYRPFL 314

  Fly   444 ALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKPK 508
            ...:|.||.||:.:|..:|:|:.:..........|...:|..|  |..|...|.:..:|.   ||
Mouse   315 DPSISPEFVVASEQFLSTMVPSGVYMRNASCHFQGIPSHNSSV--SGALRVCNSYWSREH---PK 374

  Fly   509 LQYTSQKLNNILESLLNQETMKMDAAYSGGVV------WHKDTKPTHADILAFDIQRGRDHGLLP 567
            || .::.::.:|..:.:|...:.|..    ||      |....|.:..|.||..:|||||.||..
Mouse   375 LQ-RAEDVDALLLGMASQIAEREDHV----VVEDMQDFWPGPLKFSRTDYLASCLQRGRDLGLPS 434

  Fly   568 YYRYLESCVLSRPVESWKDFEHFIP---SDVLDKLKTIY-ASWADVDLIVGGISENPVHGSIGPT 628
            |.:..|:..|| |:..|:|....:.   ..||:....:| ...:.::|:.||:.|:  ||..||.
Mouse   435 YTKAREALGLS-PISHWQDINPALSRSNGTVLEATAALYNQDLSRLELLPGGLLES--HGDPGPL 496

  Fly   629 FSCIISEQFVHVLK------QNQQKAVQKHTELVEQYRHFNGTKL-----LCLNSGLSAVPQNIF 682
            ||.|:.:|||.:..      :|.:..:....|:.|    ...|.|     ...|...||:..|:|
Mouse   497 FSTIVLDQFVRLRDGDRYWFENTRNGLFSKEEIAE----IRNTSLRDILVAVTNVDPSALQPNVF 557

  Fly   683  682
            Mouse   558  557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_650584.1	An_peroxidase	151..682	CDD:460804	158/574 (28%)
Duox1	NP_001092767.1	dual_peroxidase_like	32..591	CDD:188652	163/585 (28%)
		EFh	820..881	CDD:238008
		EFh	857..915	CDD:238008
		PLN02292	1089..>1412	CDD:215165
		NOX_Duox_like_FAD_NADP	1277..1551	CDD:99783