DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irc and GCR2

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_014200.1	Gene:	GCR2 / 855522	SGDID:	S000005143	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	352	Identity:	68/352 - (19%)
Similarity:	122/352 - (34%)	Gaps:	111/352 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 EGSSLRTECENS-------LKGNREGHYAFRRLLGSSHYRNGFYQMFPNS-----GRRETVPAAW 184
            :|:||.|..:.|       ..||..|:..  .:...|:.:|...:..||:     |.|....|..
Yeast   236 KGNSLNTSTKGSPSDLQGINNGNNNGNNG--NIGNGSNIKNYGNKNMPNNRTKKRGTRVAKNAKN 298

  Fly   185 SISKELYEPDHIQISKQQTFESNSNLALPQWAQFVEHDLSKPVSQSMSNGAPIECCSRDQIN--- 246
            ..:.:....:...|:....| ||:.::.|......:..||:.:.:.      ::..|:| :|
Yeast   299 GKNNKNSNKERNGITDTSAF-SNTTISNPGTNMLFDPSLSQQLQKR------LQTLSQD-VNSRS 355

  Fly   247 LQPRHHHPACAPILYQPG-GKYDVPSCLNYVRSALAVAD---------------CNFGGAEQLNQ 295
            |...:..|.      .|| |.::.         .|:.||               .|.|......:
Yeast   356 LTGYYTQPT------SPGSGGFEF---------GLSHADLNPNASSNTMGYNTMSNNGSHSWKRR 405

  Fly   296 ATGSLDLSQLYGFTAAAERKLRVLEGGLLRSTPRGEFDNALLPIATDTEGPSFCARATIGDGTCF 360
            :.||||::.|  ...|.|..|:      |.:|.:.:     .|:.|..||      |.|.||.
Yeast   406 SLGSLDVNTL--DDEAVEELLQ------LTNTSKRQ-----RPMTTAAEG------ALINDGP-- 449

  Fly   361 AAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRW--SDEKLFQAAKAVNVDIYRRVVIEEW 423
               |:.:|:             |:.::..:|...|...  ..|.:.:..|    :.|..::.|:
Yeast   450 ---DTNLNA-------------NNTQMKVDLNPSNSMGPIDTEAVIRPLK----EAYDAIISEK- 493

  Fly   424 LPEVLGQKMSSEIRRKQPNRALEVSNE 450
                 ||::      .|..|.||:..:
Yeast   494 -----GQRI------VQLERELELQRQ 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	60/326 (18%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	33/163 (20%)
GCR2	NP_014200.1	PHA03255	<30..>131	CDD:165513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.78878	Normalized mean entropy	S3904
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950