DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and EPX

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_000493.1	Gene:	EPX / 8288	HGNCID:	3423	Length:	715	Species:	Homo sapiens

Alignment Length:	736	Identity:	184/736 - (25%)
Similarity:	298/736 - (40%)	Gaps:	132/736 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PASKWLQYVETAL--DSVNRQKRLED---NLLGSDI--TVKNGSLSHAQLLDTL--PSLASKKDN 93
            |||...  |||::  |.:...|.|.|   |.....|  .:::||.|...||...  |..|::...
Human    25 PASPGA--VETSVLRDCIAEAKLLVDAAYNWTQKSIKQRLRSGSASPMDLLSYFKQPVAATRTVV 87

  Fly    94 K------LALKILKSSLLVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLRTECE------NSLKG 146
            :      :||.:|:..|....|.  |.|:........|.......|.:||.:.|      .::.|
Human    88 RAADYMHVALGLLEEKLQPQRSG--PFNVTDVLTEPQLRLLSQASGCALRDQAERCSDKYRTITG 150

  Fly   147 ---NREGHYAFRRLLGSSH----------YRNGFYQMF--PNSGRRE--TVPAAWSISKELYE-P 193
               |:.     |.|||:|:          |.:|....|  ..|.||.  .:|...::|.::.. |
Human   151 RCNNKR-----RPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFP 210

  Fly   194 DHIQISKQQTFESNSNLALPQWAQFVEHDL----SKPVSQSMSNGAPIECCSRDQINLQPRHHHP 254
                 :::.|.:....|...||.||::|||    ..|...:.:.|..   |.|....|      |
Human   211 -----NERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVD---CERTCAQL------P 261

  Fly   255 ACAPILYQPGGK--YDVPSCLNYVRSALAVADCNFGGAEQLNQATGSLDLSQLYGFTAAAERKLR 317
            .|.||...|...  .:...|:.:.|||.:..........|:|..|..:|.|.:||...:...:||
Human   262 PCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRVRNQINALTSFVDASMVYGSEVSLSLRLR 326

  Fly   318 VLEG--GLLRSTPRGEFDN--ALLPIATDTEGPSFCAR--ATIGDGTCFAAGDSRVNSSPFSILI 376
            ....  |||....|.: ||  ||||.....:.|.....  |.|   .||.|||:|...:|....:
Human   327 NRTNYLGLLAINQRFQ-DNGRALLPFDNLHDDPCLLTNRSARI---PCFLAGDTRSTETPKLAAM 387

  Fly   377 YTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLG----QKMSSEIR 437
            :|:|||.||::|.||::.||||:.:||:..|:.:...:.:.:...::||.|||    ::.....|
Human   388 HTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARARRTLGHYR 452

  Fly   438 RKQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKE 502
            ....|....|:|.|.: |.||..:||...:..|...   |.....|.:|.:|..     .|....
Human   453 GYCSNVDPRVANVFTL-AFRFGHTMLQPFMFRLDSQ---YRASAPNSHVPLSSA-----FFASWR 508

  Fly   503 EIYK-------PKLQYTSQKLNNILESLLNQETMKMDAAYSGGVVWHKDTKPTHADILAFDIQRG 560
            .:|:       ..|..|..|||       .|:.|.:|.....   ..:..:....|:.|.::||.
Human   509 IVYEGGIDPILRGLMATPAKLN-------RQDAMLVDELRDR---LFRQVRRIGLDLAALNMQRS 563

  Fly   561 RDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVLDKLKTIYASWADVDLIVGGISENPVHGS- 624
            |||||..|..:...|.||:|....:........|:..|...:|.:..::|:.:|.|:|..:.|:
Human   564 RDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGAR 628

  Fly   625 IGPTFSCIISEQFVH-------------VLKQNQQKAVQKHTELVEQYRHFNGTKLLCLNSGLSA 676
            :||..:|:...||..             |..:.|:||:.:          .:.::::|.|:|::.
Human   629 VGPLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSR----------ISLSRIICDNTGITT 683

  Fly   677 VPQNIFQLPSARNQMVSCEDV 697
            |.::||:........|:|..:
Human   684 VSRDIFRANIYPRGFVNCSRI 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	144/572 (25%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	100/364 (27%)
EPX	NP_000493.1	An_peroxidase	145..683	CDD:281139	148/589 (25%)
EPX	NP_000493.1	myeloperoxidase_like	289..699	CDD:188656	112/442 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820