DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and PXDN

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_036425.1	Gene:	PXDN / 7837	HGNCID:	14966	Length:	1479	Species:	Homo sapiens

Alignment Length:	819	Identity:	201/819 - (24%)
Similarity:	329/819 - (40%)	Gaps:	231/819 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QYICLLAFIIGASLLTTIDANSSRDVNAELNRIPASKWLQYVETALDSVNRQK--------RLED 61
            :|.|:....||::.::.:.:.:..||:...:...|:..::.:.|...::|..:        |..:
Human   591 RYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPN 655

  Fly    62 NLLG------SDITVK---------------------------NGSLSH------AQLLDTLPSL 87
            :||.      ...||:                           ||:..|      .|.|:.:.:|
Human   656 DLLALFRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANL 720

  Fly    88 ----ASKKDNKLALKILKSSLLVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLRTECENSLKGNR 148
                |.::.|..:...........:..|  ||:          |.|: .|:||.
Human   721 SGCTAHRRVNNCSDMCFHQKYRTHDGTC--NNL----------QHPM-WGASLT----------- 761

  Fly   149 EGHYAFRRLLGSSHYRNGF--------YQMFPNSGRRETVPAAWS---ISKELYEPDHIQISKQQ 202
                ||.||| .|.|.|||        ::::  :|....:|...|   |..|...||     :|.
Human   762 ----AFERLL-KSVYENGFNTPRGINPHRLY--NGHALPMPRLVSTTLIGTETVTPD-----EQF 814

  Fly   203 TFESNSNLALPQWAQFVEHDLSKPV---SQS-MSNGAPIEC---CSRDQINLQPRHHHPACAPIL 260
            |.      .|.||.||::|||...|   ||: .|:|.  .|   ||.|          |.|..::
Human   815 TH------MLMQWGQFLDHDLDSTVVALSQARFSDGQ--HCSNVCSND----------PPCFSVM 861

  Fly   261 YQP-------GGKYDVPSCLNYVRSALAVADCNFG----------GAEQLNQATGSLDLSQLYGF 308
            ..|       |.:     |:.:|||:..   |..|          ..||:||.|..:|.|.:||.
Human   862 IPPNDSRARSGAR-----CMFFVRSSPV---CGSGMTSLLMNSVYPREQINQLTSYIDASNVYGS 918

  Fly   309 TAAAERKLRVLEG--GLLRSTPRGEFDNALLPIATDTEGPSFCAR----ATIGDGTCFAAGDSRV 367
            |....|.:|.|..  ||||..........|||.||..  |:.|.|    :.|   .||.|||.|.
Human   919 TEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGP--PTECMRDENESPI---PCFLAGDHRA 978

  Fly   368 NSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKL-FQAAKAVNVDIYRRVVIEEWLPEVLGQ- 430
            |.......::|::.|.||::|.||.:.||.|..:.: ::..|.|..:| :.:..:.|||::||:
Human   979 NEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEI-QHITYQHWLPKILGEV 1042

  Fly   431 --KMSSEIRRKQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELP 493
              :...|.....|.....:.|.||.||.||..::: |.||        |..::|.|.: ....||
Human  1043 GMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLV-NPLL--------YRLDENFQPI-AQDHLP 1097

  Fly   494 TKNLFELKEEIYKP---------------------KLQYTSQKLN-NILESLLNQ-ETMKMDAAY 535
                  |.:..:.|                     |::..||.|| .:.|.|.:. .|:.:|.|
Human  1098 ------LHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTVALDLA- 1155

  Fly   536 SGGVVWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPS-DVLDKL 599
                              |.:||||||||:.||:.|...|.|| ...:::|.::.|.: ::.:||
Human  1156 ------------------AINIQRGRDHGIPPYHDYRVYCNLS-AAHTFEDLKNEIKNPEIREKL 1201

  Fly   600 KTIYASWADVDLIVGGISENPVHGS-IGPTFSCIISEQFVHVLKQN----QQKAVQKHTELVEQY 659
            |.:|.|..::||....:.|:.|.|| :|||..|::|.||..:...:    :...|....:|. |.
Human  1202 KRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLT-QI 1265

  Fly   660 RHFNGTKLLCLNS-GLSAVPQNIFQLPSARNQMVSCEDV 697
            :..:..::||.|: .::.|..::|::....:...||:::
Human  1266 KQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEI 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	166/594 (28%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	113/381 (30%)
PXDN	NP_036425.1	leucine-rich repeat	45..63	CDD:275380
		leucine-rich repeat	66..87	CDD:275380
		LRR 1	87..108
		LRR_4	110..151	CDD:289563
		LRR_8	111..170	CDD:290566
		LRR 2	111..132
		leucine-rich repeat	112..135	CDD:275378
		LRR_4	135..175	CDD:289563
		LRR 3	135..156
		leucine-rich repeat	136..159	CDD:275378
		LRR_8	158..>195	CDD:290566
		LRR 4	159..180
		leucine-rich repeat	160..183	CDD:275378
		leucine-rich repeat	184..196	CDD:275378
		TPKR_C2	192..243	CDD:301599
		Ig	246..333	CDD:299845
		I-set	246..333	CDD:254352
		I-set	342..429	CDD:254352
		Ig	346..429	CDD:299845
		I-set	433..519	CDD:254352
		Ig3_Peroxidasin	446..519	CDD:143222
		I-set	525..611	CDD:254352	4/19 (21%)
		Ig4_Peroxidasin	542..610	CDD:143223	4/18 (22%)
		An_peroxidase	741..1282	CDD:281139	175/645 (27%)
		peroxidasin_like	864..1303	CDD:188658	133/489 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1342..1380
		VWC	1415..1470	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820