DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and Lpo

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_536345.2	Gene:	Lpo / 76113	MGIID:	1923363	Length:	710	Species:	Mus musculus

Alignment Length:	775	Identity:	184/775 - (23%)
Similarity:	314/775 - (40%)	Gaps:	170/775 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLAFIIGASLLTTIDANSSRDVNAELNRI-----PASKWLQYVETALDSVNRQK----------- 57
            |.|.:...:||.|. |::|.|..||.:.|     ....|:.  :..|||.:|.|
Mouse     7 LPALLASLTLLQTA-ASASDDPTAETDIIHDTVEEVKVWVN--KAFLDSRDRLKMAMTTKIHSTR 68

  Fly    58 RLEDNLLGSD----ITVKNGSLSHAQLLDTLPSLASKKDNKLALKI----LKSSLLVFNSECLPN 114
            .|.|.|..:.    ..:::|.:....|         ||.::....:    |..:||.:.:.|.|
Mouse    69 HLSDYLKHAKGRTRTAIRSGQVWEESL---------KKLSQFLTNVTGQGLDLTLLSWEAGCDP- 123

  Fly   115 NIDGDKCRSYLEQKPLPE-----GSSLRT---ECENSL-----KGNREGHYAFRRLLGSSHYRNG 166
                          |.|.     .|..||   .|.|..     ..||    |..|.| .:.|.:|
Mouse   124 --------------PAPTMTCNISSPYRTITGYCNNRKNPALGSANR----ALARWL-PAEYEDG 169

  Fly   167 FYQMFPNSGRRETVPAAWSISK-----ELYEPDHIQ------ISKQQTFESNSNLALPQWAQFVE 220
            .           ::|..|:..|     .|.:|..:.      ::::...:...::...||.|.|:
Mouse   170 L-----------SLPYGWTPGKMRNGFPLPQPREVSNQIAAYLNEEDVLDQKRSMLFMQWGQIVD 223

  Fly   221 HDLSKPVSQSMSNG--APIECCSRDQINLQPRHHHPACAPILYQPG-------GKYDVPSCLNYV 276
            ||:.......|.:.  ...:|   |:..:|..:    |.||::.||       ||     |:.:.
Mouse   224 HDMDFAPETEMGSDTYTKAQC---DEHCIQGDN----CFPIMFPPGDPKLKTQGK-----CMPFF 276

  Fly   277 RSALAVADCNFG--GAEQLNQATGSLDLSQLYGFTAAAERKLRVLEGGL-LRSTPRGEFDNA--L 336
            |:........:.  ..||:|..|..||.|.:|....:...:||.|...| |.:......||.  .
Mouse   277 RAGFVCPTPPYKSLAREQINALTSFLDASLVYSPEPSLANRLRNLSSPLGLMAVNEEVSDNGRPF 341

  Fly   337 LPIATDTEGPSFCARATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDE 401
            .|.......|.....||.| ..||.|||||.:........:|:|:|.||::|.||.:.||.|..|
Mouse   342 PPFVKMKPSPCEVINATAG-VPCFLAGDSRASEQILLATSHTLFIREHNRLATELSRLNPHWDRE 405

  Fly   402 KLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQP-NRALE--VSNEFAVAAIRFYFSML 463
            .|:|.|:.:.....:.....::||.:||.:|...|...|. |.:::  :||.|.. |:||....:
Mouse   406 TLYQEARKIMGAFIQITTFRDYLPILLGDEMQKWIPPYQGYNESVDPRISNVFTF-ALRFGHLEI 469

  Fly   464 PNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKPKLQYTSQKLNNILESLL--NQ 526
            |:.:..|.::...:|:|         .|||...:|.....:.|      ...::.::..||  |.
Mouse   470 PSTVYRLDENYQPWGSE---------SELPLHTVFFNTWRLVK------DGGIDPLVRGLLAKNA 519

  Fly   527 ETMKMDAAYSGGVVWHKDTKPTHA----DILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDF 587
            :.|..:...: |.:.:|..:|.|.    |:.:.:|||.||||...|..:...|.||:| ::.::.
Mouse   520 KLMHQNKMMT-GELRNKLFQPNHTIHGFDLASINIQRSRDHGQPGYNSWRAFCGLSQP-KTLEEL 582

  Fly   588 EHFIPSDVL-DKLKTIYASWADVDLIVGGISENPVH-GSIGPTFSCIISEQFVH----------- 639
            ...:.::|| .||..:|.:.:::|:.:|.::|..|| |.:||..:|::.:||..
Mouse   583 SAVMKNEVLAKKLMDLYGTPSNIDIWLGAVAEPLVHRGRVGPLLTCLLGQQFQRIRDGDRFWWEN 647

  Fly   640 --VLKQNQQKAVQKHTELVEQYRHFNGTKLLCLNSGLSAVPQNIFQLPSARNQMVSCEDV 697
              |..:.|::::||          .:.::|:|.|:|:..||.|.||..:..:..|.|..:
Mouse   648 PGVFTEKQRESLQK----------MSFSRLVCDNTGIDKVPLNPFQANAYPHGFVDCSSI 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	137/569 (24%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	100/360 (28%)
Lpo	NP_536345.2	myeloperoxidase_like	281..692	CDD:188656	115/439 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810