DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and TPO

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	XP_024308853.1	Gene:	TPO / 7173	HGNCID:	12015	Length:	947	Species:	Homo sapiens

Alignment Length:	795	Identity:	195/795 - (24%)
Similarity:	303/795 - (38%)	Gaps:	240/795 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 WLQYVETALDSV-NRQKRLEDNLLGSDI---TVKNGSLSHAQLL--DTLP--------------- 85
            |.:..|:.:.|| ...|||.|..:.:.:   ..|.|.||.||||  ..||
Human    43 WGKPEESRVSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIME 107

  Fly    86 -SLASKKDNKLALKILKS------------SLLVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLR 137
             |:.:.| .|:.||..:|            |::...|.|||          |:          |.
Human   108 TSIQAMK-RKVNLKTQQSQHPTDALSEDLLSIIANMSGCLP----------YM----------LP 151

  Fly   138 TECENSLKGNREGHYAFRRLLGSSH---------------------YRNGF-----------YQM 170
            .:|.|:...|:     :|.:.|:.:                     |.:||           |..
Human   152 PKCPNTCLANK-----YRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNG 211

  Fly   171 FPNSGRRETVPAAWSISKELYEPDHIQISKQQTFESNSNLALPQWAQFVEHDLS-KPVSQS---M 231
            ||....||.......:|.|:...|          :..|:| |..|.|:::||:: .|.|.|   .
Human   212 FPLPPVREVTRHVIQVSNEVVTDD----------DRYSDL-LMAWGQYIDHDIAFTPQSTSKAAF 265

  Fly   232 SNGAPIECCSRDQ-----INLQPRHHHPACAPILYQPGGKYDVPSCLNYVRSALAVADCNFG--G 289
            ..||..:....:|     |.| |....||..            .:||.:.||:.|   |..|  |
Human   266 GGGADCQMTCENQNPCFPIQL-PEEARPAAG------------TACLPFYRSSAA---CGTGDQG 314

  Fly   290 A-----------EQLNQATGSLDLSQLYGFTAAAERKLR--VLEGGLLRSTPR-GEFDNALLPIA 340
            |           :|:|..|..||.|.:||.:.|.||:||  ....||||...| .:...|.||.
Human   315 ALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPF- 378

  Fly   341 TDTEGPSFCA--RATIGD--GTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDE 401
            .....|:.||  ....|:  |.||.|||.|.:..|....::|:::|.||::||.||..|..||.:
Human   379 VPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSAD 443

  Fly   402 KLFQAAKAVNVDIYRRVVIEEWLPEVLG----QKMSSEIRRKQPNRALEVSNEFAVAAIRFYFSM 462
            .::|.|:.|...:::.:.:.:::|.:||    |:...............|||.|:.||.||..:.
Human   444 AVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHAT 508

  Fly   463 LPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKP-------------------- 507
            :...:..|...               .:|.|......|.:..:.|
Human   509 IHPLVRRLDAS---------------FQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARP 558

  Fly   508 -KLQYTSQKLNNILES----LLNQETMKMDAAYSGGVVWHKDTKPTHADILAFDIQRGRDHGLLP 567
             |||...|.:|..|..    |.|..|:                     |:.:.::||||||||..
Human   559 AKLQVQDQLMNEELTERLFVLSNSSTL---------------------DLASINLQRGRDHGLPG 602

  Fly   568 YYRYLESCVLSRPVESWKDFEHFIPS-DVLDKLKTIYASWADVDLIVGGISENPV-HGSIGPTFS 630
            |..:.|.|.|.| :|:..|....|.| .|.||:..:|....::|:.:||::||.: ....||.|:
Human   603 YNEWREFCGLPR-LETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFA 666

  Fly   631 CIISEQF-------------VHVLKQNQQKAVQKHTELVEQYRHFNGTKLLCLNSGLSAVPQNIF 682
            |:|.:|.             .||....|::.::||:.          ::::|.|:||:.||.:.|
Human   667 CLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSL----------SRVICDNTGLTRVPMDAF 721

  Fly   683 QLPSARNQMVSCEDV 697
            |:........||:.:
Human   722 QVGKFPEDFESCDSI 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	152/625 (24%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	106/395 (27%)
TPO	XP_024308853.1	thyroid_peroxidase	179..746	CDD:188657	159/633 (25%)
TPO	XP_024308853.1	CCP	754..807	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820