DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and ptgs2

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_001025697.1	Gene:	ptgs2 / 595089	XenbaseID:	XB-GENE-482133	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	575	Identity:	119/575 - (20%)
Similarity:	203/575 - (35%)	Gaps:	149/575 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 FNSECLPNNIDGDKCRS-------YLEQKPLPEGSSLRTECENSLKGNREGHYAFRRLLGSSHYR 164
            :..:|......|:.|..       .|:.||.|          |::      ||..      :|::
Frog    41 YECDCTRTGFYGENCTKPEFLSWLRLKLKPAP----------NTV------HYIL------THFK 83

  Fly   165 NGFYQMFPN-SGRRETVPAAWSISKELYEPDHIQISKQQTFESNSNLALPQWAQF---------- 218
             |.:.:..| |..|:.:     :...|....|: |....|:  ||:.....|..|
Frog    84 -GLWNIVNNISFLRDAI-----MRYVLTSRSHL-IDSPPTY--NSHYGYKSWEAFSNLSYYTRTL 139

  Fly   219 --VEHDLSKPVSQSMSNGAPIECCSRDQINLQPRHHHPACAPILYQPGGKYDVPSCLNYVRSALA 281
              ||.|...|:........|......::. |..|...|       .|.|.       |.:.:..|
Frog   140 PPVERDCPTPMGVKGMKELPSAKLVVEKF-LMRRKFIP-------DPQGS-------NVMFAFFA 189

  Fly   282 V--------ADCNFGGAEQLNQATG-SLDLSQLYGFTAAAERKLRVLEGGLLR-STPRGEFDNAL 336
            .        .|...|.|  ..:|.| .:||:.:||.:...:.|||:::||.|: ....||    :
Frog   190 QHFTHQFFRTDMAKGAA--FTKALGHGVDLNHIYGESLERQHKLRLMKGGKLKYQMISGE----M 248

  Fly   337 LPIATDTEGPSFCARATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDE 401
            .|....|.|........|.|...||.|.......|..::..||::|.||:|...|...:|.|.||
Frog   249 YPPTVKTTGVDMVYPPHIPDHLQFAVGQEVFGLVPGLMMYSTIWLREHNRVCDILSNEHPEWDDE 313

  Fly   402 KLFQAAKAVNVDIYRRVVIEEWLPEVLGQ----KMSSEIRRKQ----PNRALEVSNEFAVAAIRF 458
            ::||.|:.:.:....::|||:::..:.|.    |...|:...|    .||   :|.||  ..:..
Frog   314 RIFQTARLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQKFQYQNR---ISAEF--NTLYH 373

  Fly   459 YFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYK-PKLQYTSQKLNNILES 522
            :..:||                               :.|.:.|:.|. |:..|     ||.:
Frog   374 WHPLLP-------------------------------DTFAISEKEYSYPQFLY-----NNSV-- 400

  Fly   523 LLNQETMKMDAAYS----GGVVWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVES 583
            :||....:|..::|    |.|...::.......:....|:..|:........|.:..:| :|.||
Frog   401 MLNHGLTEMVESFSRQTAGRVAGGRNFPAAITRVAVASIEHSREMRYQSLNEYRKRFML-KPFES 464

  Fly   584 WKDFEHFIPSDVLDKLKTIYASWADVDLIVGGISENPVHGS--------IGPTFS 630
            :::...  ..::..:|:.:|.....::...|.:.|.|..|:        ||..||
Frog   465 FEELTG--EKEMSAELEKLYGDIDAMEFYPGLLVEQPRPGAIFGETMVEIGAPFS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	111/524 (21%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	82/364 (23%)
ptgs2	NP_001025697.1	EGF_CA	20..56	CDD:238011	2/14 (14%)
ptgs2	NP_001025697.1	prostaglandin_endoperoxide_synthase	76..563	CDD:188648	111/524 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000