Protein Alignment Irc and PTGS2

DIOPT Version :10

• Sequence 1: NP_650584.1
• Gene: Irc / 42049
• FlyBaseID: FBgn0038465
• Length: 697
• Species: Drosophila melanogaster
• Sequence 2: NP_000954.1
• Gene: PTGS2 / 5743
• HGNCID: 9605
• Length: 604
• Species: Homo sapiens
• Alignment Length: 348
• Identity: 75/348 - (21%)
• Similarity: 135/348 - (38%)
• Gaps: 62/348 - (17%)

  Fly   300 LDLSQLYGFTAAAERKLRVLEGGLLR-STPRGEFDNALLPIATDTEGPSFCARATIGDGTCFAAG 363
            :||:.:||.|.|.:||||:.:.|.:: ....||.   ..|...||:. .......:.:...||.|
Human   214 VDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEM---YPPTVKDTQA-EMIYPPQVPEHLRFAVG 274

  Fly   364 DSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVL 428
            .......|..::..||::|.||:|...|||.:|.|.||:|||.::.:.:....::|||:::..:.
Human   275 QEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLS 339

  Fly   429 GQ----KMSSEIRRKQPNRALEVSNEFAVA--AIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVF 487
            |.    |...|:..   |:..:..|..|..  .:..:..:||:..
Human   340 GYHFKLKFDPELLF---NKQFQYQNRIAAEFNTLYHWHPLLPDTF-------------------- 381

  Fly   488 ISKELPTKNLFELKEEIYKPKLQYTSQKLNN--ILESLLNQETMKMDAAYSGGVVWHKDTKPTHA 550
                           :|:..|..|.....||  :||..:.|.........:|.|...::..|...
Human   382 ---------------QIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQ 431

  Fly   551 DILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVLDKLKTIYASWADVDLIVGG 615
            .:....|.:.|......:..|.:..:| :|.||:::...  ..::..:|:.:|.....|:|....
Human   432 KVSQASIDQSRQMKYQSFNEYRKRFML-KPYESFEELTG--EKEMSAELEALYGDIDAVELYPAL 493

  Fly   616 ISENP----VHG----SIGPTFS 630
            :.|.|    :.|    .:|..||
Human   494 LVEKPRPDAIFGETMVEVGAPFS 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_650584.1	An_peroxidase	151..682	CDD:460804	75/348 (22%)
PTGS2	NP_000954.1	EGF_CA	19..54	CDD:238011
		prostaglandin_endoperoxide_synthase	75..562	CDD:188648	75/348 (22%)