Protein Alignment Irc and PTGS1

DIOPT Version :10

• Sequence 1: NP_650584.1
• Gene: Irc / 42049
• FlyBaseID: FBgn0038465
• Length: 697
• Species: Drosophila melanogaster
• Sequence 2: NP_000953.2
• Gene: PTGS1 / 5742
• HGNCID: 9604
• Length: 599
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 121/604 - (20%)
• Similarity: 212/604 - (35%)
• Gaps: 159/604 - (26%)

  Fly   164 RNGFYQMFPNSGRRETVPAAWSISKELYEPD----HIQISKQQTFESNSNLALPQWAQFVEHDLS 224
            |.|:      ||...|:|..|:..:....|.    |..::..:.|....|      |.|:...|.
Human    60 RTGY------SGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVN------ATFIREMLM 112

  Fly   225 KPVSQSMSN---GAPIECCSRDQINLQPRHH----------HPACAPILYQPGGKYDVPSCLNYV 276
            :.|....||   ..|....:.|.|:.:...:          .|...|......||..:|......
Human   113 RLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLA 177

  Fly   277 RSAL----------------AVADCNFGGAEQLNQATGSL------------DLSQLYGFTAAAE 313
            |..|                |....:|  ..|..:.:|.:            ||..:||.....:
Human   178 RRFLLRRKFIPDPQGTNLMFAFFAQHF--THQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ 240

  Fly   314 RKLRVLEGGLLRSTPRGEFDNALLPIATDTEGPSFCARAT-IGDGTCFAAGDSRVNSSPFSILIY 377
            .:||:.:.|.|:..   ..|..:.|.:.: |.|....... |...:..|.|.......|..:|..
Human   241 YQLRLFKDGKLKYQ---VLDGEMYPPSVE-EAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYA 301

  Fly   378 TIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQPN 442
            |:::|.||:|...||..:|.|.||:|||..:.:.:....::||||::.::.|..:..:.   .|.
Human   302 TLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF---DPE 363

  Fly   443 RALEVSNEFAVAAIRFYFSMLPNELLN---LTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEI 504
            ....|..::     |...:|..|.|.:   |..|:...|::                     |..
Human   364 LLFGVQFQY-----RNRIAMEFNHLYHWHPLMPDSFKVGSQ---------------------EYS 402

  Fly   505 YKPKLQYTSQKLNNILESLLNQETMKMDAAYSGGVVWHKDTKPTHADILAFD-IQRGRDHGLLPY 568
            |:..|..||..::..:|:|::..:.::.....||  .:.|....|   :|.| |:..|:..|.|:
Human   403 YEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGG--RNMDHHILH---VAVDVIRESREMRLQPF 462

  Fly   569 YRYLESCVLSRPVESWKDFEHFI-PSDVLDKLKTIYASWADVD-------LIVGGISENPVHG-- 623
            ..|.:...: :|..|   |:..: ..::..:|:.:|   .|:|       |::.....|.:.|
Human   463 NEYRKRFGM-KPYTS---FQELVGEKEMAAELEELY---GDIDALEFYPGLLLEKCHPNSIFGES 520

  Fly   624 --SIGPTFSC-------IISEQF-----------VHVLKQNQQKAVQKHTELVEQYRHFNGTKLL 668
              .||..||.       |.|.::           .:::|....|                  ||:
Human   521 MIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLK------------------KLV 567

  Fly   669 CLNSGLSAVPQNIFQLPSA 687
            |||:  ...|...|::|.|
Human   568 CLNT--KTCPYVSFRVPDA 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_650584.1	An_peroxidase	151..682	CDD:460804	118/597 (20%)
PTGS1	NP_000953.2	EGF_CA	32..69	CDD:238011	4/14 (29%)
		prostaglandin_endoperoxide_synthase	89..575	CDD:188648	109/558 (20%)