DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and tpo

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	XP_021322945.1	Gene:	tpo / 569363	ZFINID:	ZDB-GENE-110519-2	Length:	672	Species:	Danio rerio

Alignment Length:	690	Identity:	175/690 - (25%)
Similarity:	293/690 - (42%)	Gaps:	144/690 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 AQLLDTLPSLASKKDNK-----------LALKILKSSLLVFNSECLPNNIDGDKCRSYLEQKPLP 131
            |::..|..:|..:|.::           |::|.::.   :.|....|.......|.:..|.:
Zfish    40 AEIFQTTLTLLKEKSSRRQRRSVQISEVLSVKAVER---IANLSGCPRTFQSTTCATDEEYR--- 98

  Fly   132 EGSSLRTECENSLKGNREGHYAFRRLLGSSHYRNGFYQMFP---NSGRRETVPAAWSISKELYE- 192
               |:...|     .||:..:     .||::  .|..:..|   ..|  |..|..|:..:: |.
Zfish    99 ---SITGVC-----NNRKNPF-----WGSAN--TGLARWLPAEYEDG--ENQPKGWNAGRQ-YNG 145

  Fly   193 ---PDHIQISKQQTFESNSNL--------ALPQWAQFVEHDLS-KPVSQSMSNGAPIECCSRDQI 245
               |...::||:....|:|.|        .|..|.|:::||:| .|.|.|.::..|...|.|..:
Zfish   146 FQLPPVREVSKRIIRSSSSALQEDRDYSQMLVDWGQYIDHDISFTPQSSSQTSFTPGFDCLRTCV 210

  Fly   246 NLQPRHHHPACAPILYQPGGKYDVP-----SCLNYVRSALAVADCNFGGAEQLNQATGSLDLSQL 305
            :..|      |.||..    ..|.|     |||.:.||:   ..|.....:|||..|..:|.|.:
Zfish   211 SADP------CFPIQI----SRDDPLSRNSSCLPFFRSS---PSCTGLQRQQLNSITSFIDASTV 262

  Fly   306 YGFTAAAERKLRVLEGGLLRSTPRGEFDNALLPIATDTEGPSFC-----------ARATIGDGTC 359
            ||.:...::.||...|.|..|....:.....||  :..:.||.|           ||.     .|
Zfish   263 YGSSEEQQQILRSSTGLLAVSEEFWDTGRPFLP--SVPQRPSACLQQPGSPALLEARV-----EC 320

  Fly   360 FAAGDSRVNS-SPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEW 423
            |||||||||. .|.::| :|::||.||::|..|.|.|..|..::::|..:.:...:::...:.::
Zfish   321 FAAGDSRVNEVLPLAVL-HTLWMREHNRLAELLAQINTHWGKQRVYQETRKIIGALHQIFTMRDY 384

  Fly   424 LPEVLGQKMSSEIRRKQP--NRALE--VSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQ 484
            :|:|:||:..:|......  |.:::  |||.||.||.||....:...|..|.:     ..:::.:
Zfish   385 IPKVIGQESVNEFLGPYEGYNESVDPSVSNVFATAAFRFGHVTISPYLRRLNQ-----SFQEDER 444

  Fly   485 YVFISKELPTKNLFELKEEIYKPKLQYTSQKLNNILESLLNQETMKMDAAYSGGVVWHKDTK--- 546
            |..::          |::..:.|........|:.:|.:||:...:..|..:   ::..:.|:
Zfish   445 YETLT----------LQQSFFSPWRLVREGGLDPVLRALLSAPAVLQDQEH---LMTEELTERLL 496

  Fly   547 ----PTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVLDK-LKTIYASW 606
                |.:.|:.|.::||||||||..|..:...|.|.| |||..|....:.||.|.| :..:|...
Zfish   497 VLNVPQNLDLAALNLQRGRDHGLPGYNAWRVFCGLDR-VESRSDLLKLVGSDDLVKEIMDLYGHP 560

  Fly   607 ADVDLIVGGISENPVHGS-IGPTFSCIISEQFVH-------------VLKQNQQKAVQKHTELVE 657
            .:||:.:||:.|.|:.|: .||.|||:|.:|...             |....|:..:|.|:.
Zfish   561 DNVDVWLGGLLERPLSGARTGPLFSCLIGKQMKKLRDGDRFWWLNPGVFSAEQRHELQTHSL--- 622

  Fly   658 QYRHFNGTKLLCLNSGLSAVPQNIFQLPSARNQMVSCEDV 697
                   ::::|.||||..||.:.|:..|.......|..|
Zfish   623 -------SRVICDNSGLMEVPLDAFRRSSYPEDFHLCGSV 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	151/579 (26%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	106/371 (29%)
tpo	XP_021322945.1	An_peroxidase_like	113..665	CDD:326323	161/598 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010