DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and Pxdn

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_001258190.1	Gene:	Pxdn / 554172	RGDID:	1560694	Length:	1475	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	177/615 - (28%)
Similarity:	270/615 - (43%)	Gaps:	142/615 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 AFRRLLGSSHYRNGFYQMFP---NSGRR---ETVPAAWSISKELYEPDHIQISKQQTFESNSNLA 211
            ||.||| .:.|.|||..  |   ||.|:   ..:|....:|..|...:.|...:|.|.      .
  Rat   759 AFERLL-KAVYENGFNT--PRGINSQRQYNGHVLPMPRLVSTTLIGTEVITPDEQFTH------M 814

  Fly   212 LPQWAQFVEHDLSKPV---SQS-MSNGAPIEC---CSRDQINLQPRHHHPACAPILYQP------ 263
            |.||.||::|||...|   ||: .|:|.  .|   ||.|          |.|..::..|
  Rat   815 LMQWGQFLDHDLDSTVVALSQARFSDGQ--HCSSVCSND----------PPCFSVMIPPNDPRVR 867

  Fly   264 -GGKYDVPSCLNYVRSALAVADCNFG----------GAEQLNQATGSLDLSQLYGFTAAAERKLR 317
             |.:     |:.:|||:..   |..|          ..||:||.|..:|.|.:||.|....|.:|
  Rat   868 SGAR-----CMFFVRSSPV---CGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTDHEARSIR 924

  Fly   318 VLEG--GLLRSTPRGEFDNALLPIATDTEGPSFCAR----ATIGDGTCFAAGDSRVNSSPFSILI 376
            .|..  ||||..........|||.||..  |:.|.|    :.|   .||.|||.|.|.......:
  Rat   925 DLASHRGLLRQGIVQRSGKPLLPFATGP--PTECMRDENESPI---PCFLAGDHRANEQLGLTSM 984

  Fly   377 YTIFMRNHNKVAAELKQRNPRWSDEKLF-QAAKAVNVDIYRRVVIEEWLPEVLGQ---KMSSEIR 437
            :|::.|.||::||||.:.||.|..:.:: :..|.|..:| :.:....|||::||:   ||..|.|
  Rat   985 HTLWFREHNRIAAELLKLNPHWDGDTVYHETRKIVGAEI-QHITYRHWLPKILGEVGMKMLGEYR 1048

  Fly   438 RKQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKE 502
            ...|:....:.|.||.||.||..::: |.||        |..::|      .:.:|..:: .|.:
  Rat  1049 GYDPSVNAGIFNAFATAAFRFGHTLI-NPLL--------YRLDEN------FEPIPQGHV-PLHK 1097

  Fly   503 EIYKP---------------------KLQYTSQKLN-NILESLLNQ-ETMKMDAAYSGGVVWHKD 544
            ..:.|                     |::..||.|| .:.|.|.:. .|:.:|.|
  Rat  1098 AFFSPFRIVNEGGIDPLLRGLFGVAGKMRIPSQLLNTELTERLFSMAHTVALDLA---------- 1152

  Fly   545 TKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVL-DKLKTIYASWAD 608
                     |.:||||||||:.||:.|...|.|| ...:::|.::.|.|.|: :||:.:|.|..:
  Rat  1153 ---------AINIQRGRDHGIPPYHDYRVYCNLS-AAYTFEDLKNEIKSPVIREKLQRLYGSTLN 1207

  Fly   609 VDLIVGGISENPVHGS-IGPTFSCIISEQFVHVLKQN----QQKAVQKHTELVEQYRHFNGTKLL 668
            :||....:.|:.|.|| :|||..|::|.||..:...:    :...|....:|. |.:..:..::|
  Rat  1208 IDLFPALMVEDLVPGSRLGPTLMCLLSTQFRRLRDGDRLWYENPGVFSPAQLT-QLKQTSLARIL 1271

  Fly   669 CLNS-GLSAVPQNIFQLPSARNQMVSCEDV 697
            |.|| .::.|..::|::....:...||||:
  Rat  1272 CDNSDNITRVQHDVFRVAEFPHGYSSCEDI 1301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	169/587 (29%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	116/381 (30%)
Pxdn	NP_001258190.1	leucine-rich repeat	42..60	CDD:275380
		leucine-rich repeat	63..84	CDD:275380
		LRR_4	107..148	CDD:289563
		LRR_8	108..167	CDD:290566
		leucine-rich repeat	109..132	CDD:275378
		LRR_4	132..172	CDD:289563
		leucine-rich repeat	133..156	CDD:275378
		LRR_8	155..>192	CDD:290566
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..193	CDD:275378
		TPKR_C2	189..240	CDD:301599
		Ig	243..330	CDD:299845
		I-set	243..330	CDD:254352
		I-set	339..426	CDD:254352
		Ig	343..426	CDD:299845
		I-set	430..516	CDD:254352
		Ig3_Peroxidasin	443..516	CDD:143222
		I-set	522..608	CDD:254352
		Ig4_Peroxidasin	539..607	CDD:143223
		An_peroxidase	738..1279	CDD:281139	171/591 (29%)
		peroxidasin_like	861..1300	CDD:188658	137/489 (28%)
		VWC	1411..1466	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920