DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and DUOX1

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_059130.2	Gene:	DUOX1 / 53905	HGNCID:	3062	Length:	1551	Species:	Homo sapiens

Alignment Length:	578	Identity:	148/578 - (25%)
Similarity:	232/578 - (40%)	Gaps:	114/578 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 YRNGFYQMFPNSGRR--ETVPAAWS--ISKELYEPDHIQISKQQTFESNSNLALPQWAQFVEHDL 223
            |.|.....:.:.|.|  ..|||:::  :.:.|.||.                 ||.     ..||
Human    36 YNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPH-----------------LPN-----PRDL 78

  Fly   224 SKPVSQS---------------------MSNGAPIEC--CSRDQINLQPRHHHPACAPILYQPGG 265
            |..:|:.                     :|:...:|.  |..:.:|::.....|     ::.|..
Human    79 SNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIRIPPGDP-----MFDPDQ 138

  Fly   266 KYDVPSCLNYVRSALAVADCNFGGA-----EQLNQATGSLDLSQLYGFTAAAERKLRVLEGGLLR 325
            :.||  .|.:.||..   |...|.:     :..||.||.||.|.:||.:.:....||....|.|.
Human   139 RGDV--VLPFQRSRW---DPETGRSPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLA 198

  Fly   326 STPRGEF----DNALL------PIATDTEGPSFCARATIGDGTCFAAGDSRVNSSPFSILIYTIF 380
            |.|...|    .|.||      | ||...||.          ..:|.|..|.|..||...:..::
Human   199 SGPDPAFPRDSQNPLLMWAAPDP-ATGQNGPR----------GLYAFGAERGNREPFLQALGLLW 252

  Fly   381 MRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQPNRAL 445
            .|.||..|..|.:::|.|.||:|||.|:...:..|:.:.:.||||..| ||...|....:|....
Human   253 FRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFL-QKTLPEYTGYRPFLDP 316

  Fly   446 EVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKPKLQ 510
            .:|:||..|:.:|..:|:|..:..........|....|..|  |:.|...|.:..:|.   |.||
Human   317 SISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSV--SRALRVCNSYWSREH---PSLQ 376

  Fly   511 YTSQKLNNILESLLNQETMKMDAAYSGGV--VWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLE 573
             :::.::.:|..:.:|...:.|......|  .|....|.:..|.||..:|||||.| ||.|....
Human   377 -SAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLG-LPSYTKAR 439

  Fly   574 SCVLSRPVESWKDFEHFIP---SDVLDKLKTIY---ASWADVDLIVGGISENPVHGSIGPTFSCI 632
            :.:...|:..|:|....:.   ..||:....:|   .||  ::|:.||:.|:  |...||.||.|
Human   440 AALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSW--LELLPGGLLES--HRDPGPLFSTI 500

  Fly   633 ISEQFVHVLK------QNQQKAVQKHTELVEQYRH--FNGTKLLCLNSGLSAVPQNIF 682
            :.||||.:..      :|.:..:....| :|:.|:  .....:..:|...||:..|:|
Human   501 VLEQFVRLRDGDRYWFENTRNGLFSKKE-IEEIRNTTLQDVLVAVINIDPSALQPNVF 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	143/566 (25%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	107/369 (29%)
DUOX1	NP_059130.2	Peroxidase-like, mediates peroxidase activity	26..593		148/578 (26%)
		An_peroxidase	30..544	CDD:281139	143/563 (25%)
		dual_peroxidase_like	32..591	CDD:188652	148/578 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..172		5/24 (21%)
		EFh	820..881	CDD:238008
		EF-hand_7	820..880	CDD:290234
		EF-hand_7	857..921	CDD:290234
		EFh	857..915	CDD:238008
		Interaction with TXNDC11. /evidence=ECO:0000250	956..1248
		Ferric_reduct	1091..1226	CDD:280043
		NOX_Duox_like_FAD_NADP	1277..1551	CDD:99783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910