DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and DUOX2

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_001350640.1	Gene:	DUOX2 / 50506	HGNCID:	13273	Length:	1548	Species:	Homo sapiens

Alignment Length:	620	Identity:	166/620 - (26%)
Similarity:	249/620 - (40%)	Gaps:	149/620 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 PEGS----SLRTECE------NSLKGNREGHYAF---RRLLGSSHYRNGFYQ-----MFPNSGRR 177
            |.||    ||..|.:      |:|:.:..|....   ||:  .::|.:|.||     ..||. ||
Human    22 PSGSQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRV--PANYADGVYQALEEPQLPNP-RR 83

  Fly   178 ETVPAAWSISKELYEPDHIQISKQQTFESNSNLALPQWAQ-------FVEHDLSKPVSQSMSNGA 235
            .:..|...|:                       .||....       |..|.||..||.. :.|.
Human    84 LSNAATRGIA-----------------------GLPSLHNRTVLGVFFGYHVLSDVVSVE-TPGC 124

  Fly   236 PIECCSRDQINLQPRHHHPACAPILYQPGGKYDVPSCLNYVRSALAVADCNFGGA-----EQLNQ 295
            |.|.     :|::    .|...|: :.|..:.||  .|.:.||..   |...|.:     :..||
Human   125 PAEF-----LNIR----IPPGDPV-FDPDQRGDV--VLPFQRSRW---DPETGRSPSNPRDLANQ 174

  Fly   296 ATGSLDLSQLYGFTAAAERKLRVLEGGLLRSTPRGEF----DNALL------PIATDTEGPSFCA 350
            .||.||.|.:||.:.:....||...||.|.|.|...|    .|.||      | ||...||.
Human   175 VTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDP-ATGQNGPR--- 235

  Fly   351 RATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIY 415
                   ..:|.|..|.|..||...:..::.|.||..|..|.:::|.|.||:|||.|:...:..|
Human   236 -------GLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATY 293

  Fly   416 RRVVIEEWLPEVLGQKMSSEIRRKQPNRALEVSNEFAVAAIRFYFSMLP------------NELL 468
            :.:.:.||||..| ||...|....:|.....:|.||.||:.:|:.:|:|            .::|
Human   294 QNIAVYEWLPSFL-QKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVL 357

  Fly   469 NLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKPKLQYTSQKLNNILESLLNQETMKMDA 533
            |           |..|   .|:.|...|.:.::|   .|.|..| |::|.:|..:.:|.:...|
Human   358 N-----------KGFQ---SSQALRVCNNYWIRE---NPNLNST-QEVNELLLGMASQISELED- 403

  Fly   534 AYSGGVV-------WHKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFI 591
                .:|       |....|.:..|.:|..||||||.||..|.:.|.:..|..| .:|.|....:
Human   404 ----NIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIP-RNWSDLNPNV 463

  Fly   592 PSDVLDKLKTIY-ASWADVDLIVGGISENPVHGSIGPTFSCIISEQFVHVLK------QNQQKAV 649
            ...||:....:| ...:.::|::||:.|:  ||..||.||.|:.:|||.:..      :|.:..:
Human   464 DPQVLEATAALYNQDLSQLELLLGGLLES--HGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGL 526

  Fly   650 QKHTELVEQYRH--FNGTKLLCLNSGLSAVPQNIF 682
            ....| :|..|:  .....:..:|...||:..|:|
Human   527 FSKKE-IEDIRNTTLRDVLVAVINIDPSALQPNVF 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	152/578 (26%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	111/381 (29%)
DUOX2	NP_001350640.1	Peroxidase-like, mediates peroxidase activity. /evidence=ECO:0000250	30..596		163/612 (27%)
		dual_peroxidase_like	38..594	CDD:188652	160/604 (26%)
		EFh_PEF	<764..858	CDD:330173
		EFh	824..885	CDD:238008
		EF-hand_7	857..929	CDD:316058
		Interaction with TXNDC11. /evidence=ECO:0000250	960..1245
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..991
		Ferric_reduct	1088..1223	CDD:307763
		NOX_Duox_like_FAD_NADP	1274..1548	CDD:99783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910