DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and MPO

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_000241.1	Gene:	MPO / 4353	HGNCID:	7218	Length:	745	Species:	Homo sapiens

Alignment Length:	799	Identity:	194/799 - (24%)
Similarity:	302/799 - (37%)	Gaps:	210/799 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLAFIIGASLLTTIDANSSRDVNAELNRIPASKWLQYVETALDSVN-----RQKRLEDNLLGSDI 68
            ||..:.|...:......|.....|.|..:..|..|..:|.|...|:     |::.::..|
Human    29 LLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRL----- 88

  Fly    69 TVKNGSLSHAQLLDTL--PSLASKKDNK------LALKILKSSL--------------------- 104
              ::||.|..:||...  |..|::...:      :||.:|:..|
Human    89 --RSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNV 151

  Fly   105 LVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLRT---ECENSLK-----GNREGHYAFRRLLGSS 161
            |..:|.|...:: |..|         ||....||   .|.|...     .||    ||.|.| .:
Human   152 LSKSSGCAYQDV-GVTC---------PEQDKYRTITGMCNNRRSPTLGASNR----AFVRWL-PA 201

  Fly   162 HYRNGF---YQMFPNSGRRE-TVPAAWSISKELYE-PDHIQISKQQTFESNSNLALPQWAQFVEH 221
            .|.:||   |...|...|.. .|..|.::|.|:.. |     :.|.|.:...:|...||.|.::|
Human   202 EYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFP-----TDQLTPDQERSLMFMQWGQLLDH 261

  Fly   222 DLS---KPVSQ-SMSNGAPIECCSRDQINLQPRHHHPACAPILYQPGGK--YDVPSCLNYVRSAL 280
            ||.   :|.:: |...|...|.....|         |.|.|:...|...  .:...|:.:.||..
Human   262 DLDFTPEPAARASFVTGVNCETSCVQQ---------PPCFPLKIPPNDPRIKNQADCIPFFRSCP 317

  Fly   281 AVADCNFGGAEQLNQATGSLDLSQLYGFTAAAERKLRVLEG--GLLRSTPRGEFDN--ALLPIAT 341
            |....|.....|:|..|..:|.|.:||......|.||.:..  |||....|.: ||  ||||...
Human   318 ACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQ-DNGRALLPFDN 381

  Fly   342 DTEGPSFCAR--ATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLF 404
            ..:.|.....  |.|   .||.|||:|.:..|....::|:.:|.||::|.|||..||||..|:|:
Human   382 LHDDPCLLTNRSARI---PCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLY 443

  Fly   405 QAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQP-----NRALE--VSNEFAVAAIRFYFSM 462
            |.|:.:...:.:.:...::||.|||   .:.:|:..|     |.:::  ::|.| ..|.|:..::
Human   444 QEARKIVGAMVQIITYRDYLPLVLG---PTAMRKYLPTYRSYNDSVDPRIANVF-TNAFRYGHTL 504

  Fly   463 LPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKP--------KLQYTSQKLN-- 517
            :...:..|  ||.....|.|       ..:|...:|.....:...        .|..|..|||
Human   505 IQPFMFRL--DNRYQPMEPN-------PRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQ 560

  Fly   518 ------NILESLLNQETMKMDAAYSGGVVWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCV 576
                  .|.|.|..| .|::.                 .|:.|.::||.|||||..|..:...|.
Human   561 NQIAVDEIRERLFEQ-VMRIG-----------------LDLPALNMQRSRDHGLPGYNAWRRFCG 607

  Fly   577 LSRPVESWKDFEHFIPSDVLDKLKTI-------------YASWADVDLIVGGISENPV--HGSIG 626
            |.:|             :.:.:|.|:             |.:..::|:.:||:|| |:  .|.:|
Human   608 LPQP-------------ETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSE-PLKRKGRVG 658

  Fly   627 PTFSCIISEQF---------------VHVLKQNQQKAVQKHTELVEQYRHFNGTKLLCLNSGLSA 676
            |..:|||..||               |..::|.|..|            ..:..:::|.|:|::.
Human   659 PLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALA------------QISLPRIICDNTGITT 711

  Fly   677 VPQ-NIFQLPSARNQMVSC 694
            |.: |||...|.....|:|
Human   712 VSKNNIFMSNSYPRDFVNC 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	148/590 (25%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	103/390 (26%)
MPO	NP_000241.1	myeloperoxidase_like	316..728	CDD:188656	119/472 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820