DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and cysu

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster

Alignment Length:	747	Identity:	195/747 - (26%)
Similarity:	321/747 - (42%)	Gaps:	162/747 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GASLLTTIDANSSRDVNAELNRI----PASKWLQYVETALDSVNRQKRLEDNLLGS---DITV-- 70
            |.....|.||.::..::|. .||    |.|.|              |..|...:|.   ||::
  Fly    63 GPGTCITYDAINAAYLDAR-KRIHVAQPKSDW--------------KPEELATVGELLLDISIQL 112

  Fly    71 -KNGSLSHAQLLDTLPSLASKKDNKLALKILKSSLLVFNSECLPNNIDGDKCRSYLEQKPLPEGS 134
             :...||:.::...||::.:.|           :|:   .|..|....|.:||         .|.
  Fly   113 ARTYGLSYEEIEKGLPTIDTSK-----------TLI---REVCPPFFAGVECR---------PGK 154

  Fly   135 SLRTE--CENSLKGNREG--HYAFRRLLGSSHYRNGFYQMFPNSGR----RETVPAAWSISKELY 191
            ..|.:  | |:::....|  :..|:||:|.. |.:|.     |:.|    ...:|.:..:|:.::
  Fly   155 YRRFDGLC-NNIEHPTWGAANAPFQRLIGPL-YSDGI-----NAPRISVTGRDLPFSRVVSRTMH 212

  Fly   192 EPDHIQISKQQTFESNSNLALPQWAQFVEHDLS------KPVSQSMSNGAPIECCSRDQINLQPR 250
            ..|...       :....:.:..|.||::||.:      .|::::    .|.|||.|      |.
  Fly   213 PDDGFH-------DHAGTVMVIAWGQFMDHDFTLTGTPLDPINRN----DPEECCKR------PL 260

  Fly   251 H-HHPACAPILYQPGGKY-----DVPSCLNYVRSALAV-ADCNFGGAEQLNQATGSLDLSQLYGF 308
            | .||.|..|.. |...|     :| .|:::||...:. ..|..|..:|.|..||.:|.:.:||.
  Fly   261 HLKHPYCNEIRI-PDDDYFYRLFNV-KCIDFVRGFPSPRPGCKLGSRQQFNTLTGVIDANTVYGV 323

  Fly   309 TAAAERKLRVLEGGLLRSTP----RGEFDNALLPIATD--TEGPSFCARATIGDGTCFAAGDSRV 367
            ..:..||||...|||:|..|    .|..|  |||:..|  .||   |.|.. ....||..|:.||
  Fly   324 KESFARKLRTGYGGLMRMNPVFQEYGLKD--LLPLKLDIPDEG---CTRPN-KSMYCFEGGEIRV 382

  Fly   368 NSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKM 432
            |.......::|:..|.||::|..|.|.|..|.||.|||.|:.:|:.|.:.|...|:||.:||:::
  Fly   383 NEQLVLTCMHTLMAREHNRLATALAQINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEV 447

  Fly   433 SSE---IRRK-----------QPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNN 483
            ..:   :.:|           .|.    :.:.||.||.||..|:||..:...:|.:
  Fly   448 MEKFGLVLQKDGYWDGYDSTVNPG----IIDSFAGAAFRFGHSLLPTAVERWSKAH--------- 499

  Fly   484 QYVFISKELPTKNLFELKEEIYKPKLQYTSQKLNNILESLLNQETMKMDAAYSGGVVWH---KDT 545
                  |.:.:|.|.:|   |.:|...|.:..|:.....|:||....||.:.:..|..|   |:.
  Fly   500 ------KFIASKRLSDL---IRRPYDLYRAGVLDEYFMGLMNQVAQAMDDSITQEVTNHLFKKEG 555

  Fly   546 KPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVLDKLKTIYASWADVD 610
            .....|:::|::||||:.|:..|..:.:.|.|... .:|.:....:|::.:.:..:|:...||:|
  Fly   556 ARFGMDLVSFNMQRGREFGIPGYMEFRKFCGLPTS-NTWDEMYGSMPNETVLRYGSIFEHPADID 619

  Fly   611 LIVGGISENPVHGS-IGPTFSCIISEQFVHVLK--------QNQQKAVQKHTELVEQYRHFNGTK 666
            |..||:||..:.|| :||||:|:|:.|..::.:        .||..:..  .|.:::.|....::
  Fly   620 LWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRGDRFWYELPNQPSSFT--PEQLQEIRKAKLSR 682

  Fly   667 LLCLNSGLSAVPQNIFQ--LPSAR-NQMVSCE 695
            |:|.|:.|....| |:.  ||... |..|.|:
  Fly   683 LICDNTDLIDTVQ-IYPMVLPDHEINPRVPCK 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	155/569 (27%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	112/370 (30%)
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	161/593 (27%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	119/412 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I2172
eggNOG	1	0.900	-	-		E1_KOG2408
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I2076
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.970