DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and LPO

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_006142.1	Gene:	LPO / 4025	HGNCID:	6678	Length:	712	Species:	Homo sapiens

Alignment Length:	766	Identity:	188/766 - (24%)
Similarity:	321/766 - (41%)	Gaps:	154/766 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLAFIIGASLLTTIDANSSRDVNAELNRIPASKWLQYVETALDSVNRQK-----------RLEDN 62
            |.:.|:..:..:|..|.::| .:|..:.:..:| :|..:..|||..|.|           :|.:.
Human    11 LASLILLQAAASTTRAQTTR-TSAISDTVSQAK-VQVNKAFLDSRTRLKTAMSSETPTSRQLSEY 73

  Fly    63 LLGSD----ITVKNGSLSHAQL--LDTLPSLASKKDNKLALKILKSSL-------LVFNSECLP- 113
            |..:.    ..::||.:....|  |....||.:..|..|.|..|...:       :|....|.|
Human    74 LKHAKGRTRTAIRNGQVWEESLKRLRQKASLTNVTDPSLDLTSLSLEVGCGAPAPVVRCDPCSPY 138

  Fly   114 NNIDGDKCRSYLEQKPLPEGSS------LRTECENSLKGNREGHYAFRRLLGSSHYRNGFYQMFP 172
            ..|.|| |.:  .:||....::      |..|.|:.|.      ..|....|.:  ||||
Human   139 RTITGD-CNN--RRKPALGAANRALARWLPAEYEDGLS------LPFGWTPGKT--RNGF----- 187

  Fly   173 NSGRRETVPAAWSISKELYEPDHIQISKQQTFESNSNLALPQWAQFVEHDL--SKPVSQSMSNGA 235
                  .:|.|..:|.::..    .::::...:.|.:|...||.|.|:|||  :.......|..:
Human   188 ------PLPLAREVSNKIVG----YLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYS 242

  Fly   236 PIECCSRDQINLQPRHHHPACAPILYQPG-------GKYDVPSCLNYVRSALAVADCNFG--GAE 291
            ..:|   |:..:|..:    |.||::.|.       ||     |:.:.|:........:.  ..|
Human   243 KAQC---DEYCIQGDN----CFPIMFPPNDPKAGTQGK-----CMPFFRAGFVCPTPPYKSLARE 295

  Fly   292 QLNQATGSLDLSQLYGFTAAAERKLRVLEGGL-LRSTPRGEFDNALLPIATDTEGPSFC------ 349
            |:|..|..||.|.:|....:...:||.|...| |.:..:...|:.|..:..|::.||.|
Human   296 QINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTT 360

  Fly   350 ARATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDI 414
            ||.     .||.|||||.:........:|:|:|.||::|.|||:.||:|..|||:|.|:.:....
Human   361 ARV-----PCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAF 420

  Fly   415 YRRVVIEEWLPEVLGQKMSSEIRRKQ-------PNRALEVSNEFAVAAIRFYFSMLPNELLNLTK 472
            .:.:...::||.:||..|...|...|       |    .:||.|.. |.||....:|:.:..|.:
Human   421 VQIITFRDYLPILLGDHMQKWIPPYQGYSESVDP----RISNVFTF-AFRFGHLEVPSSMFRLDE 480

  Fly   473 DNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKPKLQYTSQKLNNILESLLNQET--MKMDAAY 535
            :...:|.|         .|||...||      :..........::.::..||.:::  ||.:...
Human   481 NYQPWGPE---------PELPLHTLF------FNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMM 530

  Fly   536 SGGVVWHKDTKPTHA----DILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVL 596
            : |.:.:|..:|||.    |:.|.:.||.||||...|..:...|.||:| ::.::....:.|.:|
Human   531 T-GELRNKLFQPTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQP-QTLEELNTVLKSKML 593

  Fly   597 -DKLKTIYASWADVDLIVGGISENPV-HGSIGPTFSCIISEQFVHV------------LKQNQQK 647
             .||..:|.:..::|:.:|.|:|..| .|.:||..:|::.:||..:            :..|:||
Human   594 AKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQK 658

  Fly   648 -AVQKHTELVEQYRHFNGTKLLCLNSGLSAVPQNIFQLPSARNQMVSCEDV 697
             ::||          .:.::|:|.|:.::.||::.|...|.....|.|..:
Human   659 DSLQK----------MSFSRLVCDNTRITKVPRDPFWANSYPYDFVDCSAI 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	143/566 (25%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	104/368 (28%)
LPO	NP_006142.1	An_peroxidase	138..674	CDD:281139	153/610 (25%)
LPO	NP_006142.1	myeloperoxidase_like	283..694	CDD:188656	118/447 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820