DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and Epx

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_001100507.1	Gene:	Epx / 303414	RGDID:	1311882	Length:	715	Species:	Rattus norvegicus

Alignment Length:	790	Identity:	197/790 - (24%)
Similarity:	320/790 - (40%)	Gaps:	182/790 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IQYICLLAFIIGASLLT-----TIDANSSRDVNAEL-NRIPASKWLQYVETALDSVNR-QKRLED 61
            :|.:..|..::...:||     |:.|..|...|:.| :.|..:|.|  |:||   .|| ||.:..
  Rat     1 MQLLLALLGVLATFILTQLAEGTVPAPPSPVENSVLQDCIAEAKLL--VDTA---YNRTQKSIVQ 60

  Fly    62 NLLGSDITVKNGSLSHAQLLDTL--PSLASKKDNK------LALKILKSSLLVFNSECLPNNIDG 118
            .|       ::||.|...||...  |..|:::..:      :||.:|:..|.  ..|..|.|:..
  Rat    61 RL-------QSGSASPMDLLAYFKQPVAATRRVVQAADYMHVALGLLEEKLQ--PQESRPFNVTD 116

  Fly   119 DKCRSYLEQKPLPEGSSLRTE---CENSLK------GNREGHYAFRRLLGSSHY----------- 163
            ......|.......|.:|:.:   |.|..:      .||.     |..||:|:.
  Rat   117 VLTEPQLRLLSQASGCALQDQVEKCSNKYRTITGRCNNRR-----RPWLGASNQALARWLPAEYE 176

  Fly   164 --------------RNGFYQMFPNSGRRETVPAAWSISKELYE-PDHIQISKQQTFESNSNLALP 213
                          ||||           .:|...::|.::.. |     ||:.|.:...:|...
  Rat   177 DHRSLPFGWTPGKRRNGF-----------LLPLVRAVSNQIVRFP-----SKKLTSDQGRSLMFM 225

  Fly   214 QWAQFVEHDL----SKPVSQSMSNGAPIEC---CSRDQINLQPRHHHPACAPILYQPGGKYDVP- 270
            ||.||::|||    ..|...:.:.|  ::|   |::          .|.|.||...|..    |
  Rat   226 QWGQFIDHDLDFTPESPARVTFNMG--VDCEKTCAQ----------LPPCFPIKIPPND----PR 274

  Fly   271 -----SCLNYVRSALAVADCNFGGAEQLNQATGSLDLSQLYGFTAAAERKLRVLEG--GLLRSTP 328
                 .|:.:.|||.|..........|:|..|..:|.|.:||...:...:||....  |||.:..
  Rat   275 IKSQRDCIPFFRSAPACPQNRNKVRNQINSLTSFVDASMVYGSEVSLALRLRNRTNYLGLLATNQ 339

  Fly   329 RGEFDN--ALLPIATDTEGPSFCARATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAEL 391
            :.: ||  ||||.....|.|.......:.. .||.|||||.:.:|....::|:|:|.||::|.||
  Rat   340 QFQ-DNGRALLPFDNLHEDPCLLTNRLVRI-PCFLAGDSRASETPKLAALHTLFVREHNRLATEL 402

  Fly   392 KQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRK-QPNRAL------EVSN 449
            |:.||.||.:||:..|:.:...:.:.:...::||.|||:   :.:||. .|.|..      .|:|
  Rat   403 KRLNPHWSGDKLYNEARKIVGAMVQIITYRDFLPLVLGK---ARMRRTLGPYRGYCSNVDPRVAN 464

  Fly   450 EFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYK-------P 507
            .|.: |.||..:||...:..|...   |.|...|.:|.:|..     .|.....:|:       .
  Rat   465 VFTL-AFRFGHTMLQPFMFRLDSQ---YRTSAPNSHVLLSSA-----FFASWRIVYEGGIDPILR 520

  Fly   508 KLQYTSQKLNNILESLLNQETMKMDAAYSGGVVWHKDTKPTHADILAFDIQRGRDHGLLPYYRYL 572
            .|..|..|||       .|::|.:|....   ...:..:....|:.|.::||.|||||..|..:.
  Rat   521 GLMATPAKLN-------RQDSMLVDELRD---KLFQQVRRIGLDLAALNMQRSRDHGLPGYNAWR 575

  Fly   573 ESCVLSRPVESWKDFEHFIPS-DVLDKLKTIYASWADVDLIVGGISENPVHGS-IGPTFSCIISE 635
            ..|.||:| .:.......:.: ::..|...:|.:..::|:.||.|:|..:.|: :||..:|:...
  Rat   576 RFCGLSQP-RNLAQLSRVLKNRNLARKFLNLYKTPDNIDIWVGAIAEPLLPGARVGPLLACLFEN 639

  Fly   636 QFVH-------------VLKQNQQKAVQKHTELVEQYRHFNGTKLLCLNSGLSAVPQNIFQLPSA 687
            ||..             |..:.|:||:          |..:.::::|.|:|:|.|.::||:....
  Rat   640 QFRRARDGDRFWWQKWGVFTKRQRKAL----------RRISLSRIVCDNTGISTVSRDIFRANIY 694

  Fly   688 RNQMVSCEDV 697
            ....|||..:
  Rat   695 PQGFVSCSRI 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	147/592 (25%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	102/366 (28%)
Epx	NP_001100507.1	An_peroxidase	145..679	CDD:281139	149/605 (25%)
Epx	NP_001100507.1	myeloperoxidase_like	287..699	CDD:188656	119/446 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820