DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and Lpo

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	XP_006247147.1	Gene:	Lpo / 287610	RGDID:	1310051	Length:	710	Species:	Rattus norvegicus

Alignment Length:	785	Identity:	180/785 - (22%)
Similarity:	307/785 - (39%)	Gaps:	190/785 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLAFIIGASLL-------------TTIDANSSRDVNAELNRIPASKWLQYVETALDSVNRQKR-- 58
            |||.:....||             |.|..::..:|.|.:|:           ..|||.:|.|:
  Rat     7 LLALLASLILLQTAASARNDPPAKTVIICDTVEEVKASVNK-----------AFLDSRSRLKKAM 60

  Fly    59 ---------LEDNLLGSD----ITVKNGSLSHAQLLDTLPSLASKKDNKLALKILKSSLLVFNSE 110
                     |.|.|..:.    ..::||.:....|......|.:.....|.|     :.|.:...
  Rat    61 SAEVRSTRHLSDYLKHAKGRTRTAIRNGQVWEESLKKLTQFLTNATGQGLDL-----TSLFWKVG 120

  Fly   111 CLPNNIDGDKCRSYLEQKPLPE-----GSSLRT---ECENSL-----KGNREGHYAFRRLLGSSH 162
            |.|               |.|.     .:..||   :|.|..     ..||    |..|.| .:.
  Rat   121 CNP---------------PAPAVTCNISNPYRTITGDCNNRKNPALGSANR----ALARWL-PAE 165

  Fly   163 YRNGFYQMFPNSGRRETVPAAWSISK-----ELYEPDHIQ------ISKQQTFESNSNLALPQWA 216
            |.:|.           ::|..|:..|     .|.:|..:.      ::::...:...::...||.
  Rat   166 YEDGL-----------SLPFGWTPGKTRNGYPLPQPREVSNQIAGYLNEEDVLDQKRSVLFMQWG 219

  Fly   217 QFVEHDL--SKPVSQSMSNGAPIECCSRDQINLQPRHHHPACAPILYQPG-------GKYDVPSC 272
            |.|:|||  :........|....:|   |:..:|..:    |.||::..|       ||     |
  Rat   220 QIVDHDLDFAPDTEMGTDNYTKAQC---DEHCIQGDN----CFPIMFPTGDPKLKTQGK-----C 272

  Fly   273 LNYVRSALAVADCNFGG--AEQLNQATGSLDLSQLYGFTAAAERKLRVLEGGLLRSTPRG----- 330
            :::.|:........:..  .||:|..|..||.|.:|....:...:||.|      |:|.|
  Rat   273 MSFFRAGFVCPTPPYQSLTREQINALTSFLDASLVYSPEPSMANRLRNL------SSPLGLMAVN 331

  Fly   331 ----EFDNALLPIATDTEGPSFCARATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAEL 391
                :......|.......|.....||.| ..||.|||||.:........:|:|:|.||::|.||
  Rat   332 EEVSDHGRPFPPFVKMKPSPCEVINATAG-VPCFLAGDSRASEQILLATSHTLFIREHNRLAREL 395

  Fly   392 KQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQP-NRALE--VSNEFAV 453
            ...||.|..|.|:|..:.:.....:.:...::||.:||.:|...|...|. |.:::  :||.|..
  Rat   396 STLNPHWDGETLYQETRKIMGAFIQIITFRDYLPILLGDEMQKWIPPYQGYNESVDPRISNVFTF 460

  Fly   454 AAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKPKLQYTSQKLNN 518
             |.||....:|:.:..|.::...:|:|         .|||...:|.....:.|      ...::.
  Rat   461 -AFRFGHLEIPSTVSRLDENYQPWGSE---------PELPLHTVFFNTWRLVK------DGGIDP 509

  Fly   519 ILESLLNQET--MKMDAAYSGGVVWHKDTKPTHA----DILAFDIQRGRDHGLLPYYRYLESCVL 577
            ::..||.::.  |..|...: |.:.:|..:|||.    |:.:.:|||.||||:..|..:...|.|
  Rat   510 LVRGLLAKKAKLMHQDRMMT-GELRNKLFQPTHTIHGFDLASINIQRCRDHGMPGYNSWRAFCGL 573

  Fly   578 SRPVESWKDFEHFIPSDVL-DKLKTIYASWADVDLIVGGISENPVHGS-IGPTFSCIISEQFVH- 639
            |:| ::.::....:.::|| .||..:|.:.:::|:.:|.|:|..|.|. :||..:|::..||..
  Rat   574 SQP-KTLEELSAVMENEVLAKKLLDLYGTPSNIDIWLGAIAEPLVPGGRVGPLLTCLLGHQFQRV 637

  Fly   640 ------------VLKQNQQKAVQKHTELVEQYRHFNGTKLLCLNSGLSAVPQNIFQLPSARNQMV 692
                        |..:.|::::||          .:.::|:|.|:|::.||.|.|...:..:..|
  Rat   638 RDGDRFWWENPGVFTEKQRESLQK----------LSFSRLVCDNTGITKVPLNPFLANTYPHGFV 692

  Fly   693 SCEDV 697
            .|..|
  Rat   693 DCSSV 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	136/575 (24%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	99/366 (27%)
Lpo	XP_006247147.1	An_peroxidase	136..675	CDD:281139	144/601 (24%)
Lpo	XP_006247147.1	myeloperoxidase_like	281..692	CDD:188656	113/445 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820