DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and Pxd

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_001163633.1	Gene:	Pxd / 2768671	FlyBaseID:	FBgn0004577	Length:	690	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	169/619 - (27%)
Similarity:	258/619 - (41%)	Gaps:	98/619 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 IDGDKCRSYLEQKPLPEGSSLRTECENSLKGNREGHYAFRRLLGSSHYRNGFYQMFPNSGRRETV 180
            :|| .| ::|||..|...:|                 .:.||| :..|.:|. .....|...:.:
  Fly   108 LDG-SC-NHLEQPGLGVANS-----------------KYGRLL-TPKYADGI-SAPTRSVTGDEL 151

  Fly   181 PAAWSISKELYEPDHIQISKQQTFESNSNLALPQWAQFVEHDLSKPVSQSMSNGAPIECCSRD-- 243
            |:|..:|.       :...:|...:....|...||.|.:.||:|.....:.|...|..||:.|
  Fly   152 PSARLVSL-------VAFGEQDVPDPEFTLHNMQWGQIMTHDMSMQAGGTQSKKHPTRCCTDDGR 209

  Fly   244 QINLQPRH----------HHPACAPILYQPGGKYDVPSCLNYVRSAL-AVADCNF--GGAEQLNQ 295
            .|.|...|          |.||     |...|    ..|||:||:.. ..::|.:  |.||||..
  Fly   210 LIGLDTAHKTCFAIIVPPHDPA-----YSQVG----TECLNFVRTLTDRDSNCQYQGGPAEQLTV 265

  Fly   296 ATGSLDLSQLYGFTAAAERKLRVLEGGLLRSTPRGEFDNALLPIATDTEGPSFCARATIGDGTCF 360
            .|..||||.:||.:......:|..:||.:....|.  ....||::.:..|.   ..|......|:
  Fly   266 VTSYLDLSLVYGNSIQQNSDIREFQGGRMIVEERN--GAKWLPLSRNVTGD---CDAVDASEVCY 325

  Fly   361 AAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLP 425
            .:||.|||.:|...::.||.:|.||::|..|...||.:.|..|||.|:.:|:..|:::...||||
  Fly   326 RSGDVRVNQNPGLAILQTILLREHNRIADALSALNPHYDDRTLFQEARKINIAQYQQISYYEWLP 390

  Fly   426 EVLGQK------------MSSEIRRKQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYG 478
            ..||.:            ..|.|....||....|.||.|.||.|::.|.:...|..|::...|.|
  Fly   391 IFLGGENMLKNRLIYKAPSGSYINDFDPNIDPSVLNEHATAAFRYFHSQIEGRLDLLSELRQVLG 455

  Fly   479 TEKNNQYVFISKELPTKNLFELKEEIYKPKLQYTSQKLNNILESLLNQETMKMDAAYSGGV--VW 541
            :                  ..|.:...:|.:.......:::......|.....|..:...:  ..
  Fly   456 S------------------LTLSDWFNRPGIIEVGDNFDSLTRGHATQPEELTDINFDRQIKHFL 502

  Fly   542 HKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVLDKLKTIYASW 606
            .:...|..:|:.:.||||.|||||..|....|.|.|.| ..||:.:...|...:|:|||::|.|.
  Fly   503 FRRNMPFGSDLRSLDIQRNRDHGLASYNDMREFCGLRR-AHSWEGYGDLISPPILEKLKSLYPSH 566

  Fly   607 ADVDLIVGGISENPVHGSI-GPTFSCIISEQFVHV------LKQNQQKAVQKHTELVEQYRHFNG 664
            .||||.||...|..|.|:: ||||.||::|||...      ..:|..|......:.:|:.|..:.
  Fly   567 EDVDLTVGASLEAHVAGALAGPTFLCILTEQFYRTRVGDRFFFENGDKLTGFTPDQLEELRKASM 631

  Fly   665 TKLLCLNSG-LSAVPQNIFQLPSARNQMVSCEDV 697
            .:|||.|.. :|::....|:..|..|.::.|.::
  Fly   632 ARLLCDNGNHISSMQPEAFRTVSHSNPIIPCSNI 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	155/556 (28%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	109/361 (30%)
Pxd	NP_001163633.1	An_peroxidase	105..643	CDD:281139	164/595 (28%)
Pxd	NP_001163633.1	peroxinectin_like	260..638	CDD:188655	118/401 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I2172
eggNOG	1	0.900	-	-		E1_KOG2408
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I2076
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.970