Protein Alignment Irc and ptgs2a

DIOPT Version :10

• Sequence 1: NP_650584.1
• Gene: Irc / 42049
• FlyBaseID: FBgn0038465
• Length: 697
• Species: Drosophila melanogaster
• Sequence 2: NP_705943.1
• Gene: ptgs2a / 246227
• ZFINID: ZDB-GENE-020530-2
• Length: 601
• Species: Danio rerio
• Alignment Length: 683
• Identity: 144/683 - (21%)
• Similarity: 243/683 - (35%)
• Gaps: 186/683 - (27%)

  Fly    93 NKLALKILKSSLLVFNSE---------------CLPNNIDGDKCRS-----YLEQKPLPEGSSLR 137
            |||...:|.||:.:|..|               ||....|..:|..     |.|....||   |.
Zfish     2 NKLVCLVLLSSIWIFPGEGYDPCCAQPCQNQGVCLSKGADAYECDCTRTGYYGENCTTPE---LL 63

  Fly   138 TECENSLKGNREGHYAFRRLLGSSHYRNGFYQMFPNSGRRETVPAAWSISKEL-YEPD----HIQ 197
            |..:::||....   ....:|  :||:                 :.|.|...: |..|    :|.
Zfish    64 TRIKSALKPRPN---VVHHIL--THYK-----------------SIWDIINSISYLRDGIMRYIL 106

  Fly   198 ISKQQTFES----NSNLALPQWAQFVEHDLSKPVSQSMSNGAPIECCSRDQINLQPRHHHPACAP 258
            :|:....||    |::.....|..:      ..:|......||:                |...|
Zfish   107 LSRSHLVESPPTYNADYGYKSWEAY------SNLSYYTRTLAPL----------------PQNCP 149

  Fly   259 ILYQPGGKYDVPSCL---NYV----RSALAVA-----------DCNFGGAEQLNQATG-SLDLSQ 304
            ....|..|..|...|   .::    ||:|..|           ..:|.......:|.| .:||..
Zfish   150 TPDLPNAKQVVEQVLLRKQFIPDPQRSSLMFAFFAQHFSHQFFKSDFKKGPAFTKALGHGVDLGH 214

  Fly   305 LYGFTAAAERKLRVLEGGLLR-STPRGEFDNALLPIATDTE-----GPSFCARATIGDGTCFAAG 363
            :||.|...:.|||:.:.|.|: ....||   ...|:..|.:     .|.      |.:...||.|
Zfish   215 IYGETLEVQHKLRLFKDGKLKYQVVDGE---VYPPLVKDVQVEMHYPPH------IPEEQKFAVG 270

  Fly   364 DSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVL 428
            .......|..::..||::|.||:|...:||.:|.|.||::||..:.:.:....::|||:::..:.
Zfish   271 HEAFGLVPGLMMYATIWLREHNRVCDIMKQEHPDWDDERIFQTTRLILIGETIKIVIEDYVQHLS 335

  Fly   429 GQ----KMSSEI----RRKQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQY 485
            |.    |...|:    |.:..||   ::.||  ..:..:..:||:   |....:.:||   .:|:
Zfish   336 GYNFKLKFDPELIFSERFQYQNR---IAAEF--NTLYHWHPLLPD---NFQIQDQIYG---YHQF 389

  Fly   486 VFISKELPTKNLFELKEEIYKPKLQYTSQKLNNILESLLNQETMKMDAAYSGGVVWHKDTKPTHA 550
            ||.:..:                   |:..:.|:::|...|...::    |||    ::..|...
Zfish   390 VFNNSIV-------------------TTHGIRNMVDSFTKQTAGRV----SGG----RNLPPAVQ 427

  Fly   551 DILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVLDKLKTIYASWADVDLIVGG 615
            .:....:::.|......:..|.....: :|..|:::...  ..|:..:||.:|.....|:|..|.
Zfish   428 GVAVKVLEQTRQMRYQSFNAYRRRFNM-KPYSSFEEMTG--DKDLAAQLKELYGHVDKVELYPGL 489

  Fly   616 ISENPVHGSIGPTFSCIISEQFVHVLKQNQQKAVQKHTELVEQY---RHFNG------------T 665
            :.|.....|       :..|..|.:......|.:..:.....:|   ..|.|            .
Zfish   490 LVEKSRPNS-------VFGETMVEMGAPYSLKGLMGNAICSPEYWKPSTFGGKVGFDIVNSASLK 547

  Fly   666 KLLCLN-SGLSAVPQNIFQLPSARNQMVSCEDV 697
            ||:||| ||  ..|...||:|..:.|  |.|:|
Zfish   548 KLVCLNISG--PCPMVSFQVPDVKFQ--SSENV 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_650584.1	An_peroxidase	151..682	CDD:460804	117/588 (20%)
ptgs2a	NP_705943.1	EGF_CA	25..58	CDD:238011	6/32 (19%)
		prostaglandin_endoperoxide_synthase	78..559	CDD:188648	116/580 (20%)