DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irc and IGSF9B

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	341	Identity:	72/341 - (21%)
Similarity:	102/341 - (29%)	Gaps:	137/341 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LSHAQLLDTLPSLASKKDNKLALKILKSSLLVFNSECLPNNIDGDKCRSYLEQKPLPEG----SS 135
            |:.|.|..||.:....|..|..||..|...|...           .||..|| .||..|    .|
Human   734 LAAAILFSTLAACFVNKQRKRKLKRKKDPPLSIT-----------HCRKSLE-SPLSSGKVSPES 786

  Fly   136 LRTECENSLKGNREGHYAFRRLLGSSHYR------------------------------------ 164
            :||....|...:.:|..|.:|:|..:..:
Human   787 IRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYKKTKRAISSKKYSVAKAEAEAEATTPIELIS 851

  Fly   165 ---NGFYQMFP-------NSGRRETVPAAWSISKELYEPDHIQISKQQTFESNSNLALPQWAQFV 219
               :|.:.|.|       .|.|.|..|.|        |...:....:|:.|.|.:..:|.....:
Human   852 RGPDGRFVMDPAEMEPSLKSRRIEGFPFA--------EETDMYPEFRQSDEENEDPLVPTSVAAL 908

  Fly   220 EHDLSKPVSQSMSNGAPIECCSRDQINLQPRHHHPACAPILYQPGGKYDVPSCLNYVRSALAVAD 284
            :..|: |:|.|..:..|                .||.:| .:||.| .:.|
Human   909 KSQLT-PLSSSQESYLP----------------PPAYSP-RFQPRG-LEGP-------------- 940

  Fly   285 CNFGGAEQLNQATGS--------LDLSQLYGFTAAAE------RKLRVLEGG-----LLRSTPRG 330
               ||.|...||||.        ....|.||:.:::.      ....|.|.|     ::.|.|
Human   941 ---GGLEGRLQATGQARPPAPRPFHHGQYYGYLSSSSPGEVEPPPFYVPEVGSPLSSVMSSPP-- 1000

  Fly   331 EFDNALLPIATDTEGP 346
                  ||    ||||
Human  1001 ------LP----TEGP 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	49/261 (19%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	19/76 (25%)
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653
		Ig	41..115	CDD:143165
		I-set	139..225	CDD:254352
		IGc2	153..210	CDD:197706
		I-set	229..321	CDD:254352
		Ig	235..321	CDD:299845
		IG_like	331..414	CDD:214653
		Ig	<353..414	CDD:299845
		IG_like	426..505	CDD:214653
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817		17/70 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081		33/144 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900