DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irc and Tpo

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	XP_011242158.1	Gene:	Tpo / 22018	MGIID:	98813	Length:	915	Species:	Mus musculus

Alignment Length:	812	Identity:	195/812 - (24%)
Similarity:	328/812 - (40%)	Gaps:	237/812 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ICLLAFIIGASLLTTIDANSSRDVNAELNRIPASKWLQYVETALDSV-----NRQKRLEDNLLGS 66
            :..|:||:           .|||:..  .:...|..:..|||:...|     |..||   ||...
Mouse    17 VIFLSFIL-----------RSRDILC--GKTMKSHVISAVETSQLMVDHAVYNTMKR---NLKKR 65

  Fly    67 DITVKNGSLSHAQLLD--TLPSLASKKDNKLALKILKSSLLV-------FNSECLPNNIDG---- 118
            ::      ||.||||.  .||...|...:: |.:|:::|:.|       |:::.|..:|.|
Mouse    66 EV------LSPAQLLSFFKLPESTSGAISR-AAEIMETSIQVMKREQSQFSTDALSADILGTIAN 123

  Fly   119 -DKCRSYLEQKPLPEGSSLRTECENSLKGNREGHYAFRRLLGSSH-------------------- 162
             ..|..::          |...|.::...|:     :|.:.|:.:
Mouse   124 LSGCLPFM----------LPPRCPDTCLANK-----YRPITGACNNRDHPRWGASNTALARWLPP 173

  Fly   163 -YRNGF-----------YQMFPNSGRRETVPAAWSISKELYEPDHIQISKQQTFESNS-NLALPQ 214
             |.:||           |..||       :|....:::.|     ||:|.:...|.:. :..||.
Mouse   174 VYEDGFSQPKGWNPNFLYHGFP-------LPPVREVTRHL-----IQVSNEAVTEDDQYSDFLPV 226

  Fly   215 WAQFVEHDLSKPVSQSMSNGA---PIECCSRDQINLQPRHHHPACAPILYQPGGKYDVPSCLNYV 276
            |.|:::||::. ..||.|..|   .::|      .|...:.:| |.|| ..|.......:||.:.
Mouse   227 WGQYIDHDIAL-TPQSTSTAAFWGGVDC------QLTCENQNP-CFPI-QLPSNSSGTTACLPFY 282

  Fly   277 RSALAVADCNFG--GA-----------EQLNQATGSLDLSQLYGFTAAAERKLR--VLEGGLLR- 325
            ||:.|   |..|  ||           :|:|..|..||.|.:||.:...|::||  ....||||
Mouse   283 RSSAA---CGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRV 344

  Fly   326 STPRGEFDNALLPIATDTEGPSFCARATIGDGT-------CFAAGDSRVNSSPFSILIYTIFMRN 383
            :|...:...|.||.||....|.        .||       ||.|||.|.:..|....::|:::|.
Mouse   345 NTLHLDAGRAYLPFATAACAPE--------PGTPRTNRTPCFLAGDGRASEVPALAAVHTLWLRE 401

  Fly   384 HNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLG----QKMSSEIRRKQPNRA 444
            ||::|:..|..|..||....:|.|:.|...:::.:.:.:::|::||    ::.........|...
Mouse   402 HNRLASAFKAINKHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGYNPTVN 466

  Fly   445 LEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKP-- 507
            ..|||.|:.||.||..:.:...:..|..|...:            .|||.   .:|::..::|
Mouse   467 PTVSNIFSTAAFRFGHATVHPLVRRLNTDFQEH------------TELPR---LQLRDVFFRPWR 516

  Fly   508 -------------------KLQYTSQKLNNILESLLNQE-TMKMDAAYSGGVVWHKDTKPTHADI 552
                               |||...|        |:|:| |.::....:.|.:          |:
Mouse   517 LIQEGGLDPIVRGLLARAAKLQVQGQ--------LMNEELTERLFVLSNVGTL----------DL 563

  Fly   553 LAFDIQRGRDHGLLPYYRYLESCVLSR---PVESWKDFEHFIPSDVLDKLKTIYASWADVDLIVG 614
            .:.::||||||||..|..:.|.|.|||   |.|..|...:   ..:::|:..:|....::|:.:|
Mouse   564 ASLNLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAIAN---RSMVNKIMDLYKHADNIDVWLG 625

  Fly   615 GISENPVHGS-IGPTFSCIISEQF-------------VHVLKQNQQKAVQKHTELVEQYRHFNGT 665
            |::|..:.|: .||.|:|||.:|.             .:|....|::.::||:.          .
Mouse   626 GLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENTNVFTDAQRQELEKHSL----------P 680

  Fly   666 KLLCLNSGLSAVPQNIFQLPSARNQMVSCEDV 697
            :::|.|:||:.||.:.|::........||||:
Mouse   681 RVICDNTGLTRVPVDAFRIGKFPQDFESCEDI 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	148/622 (24%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	103/397 (26%)
Tpo	XP_011242158.1	thyroid_peroxidase	161..722	CDD:188657	156/630 (25%)
		CCP	730..783	CDD:153056
		EGF_CA	784..826	CDD:311536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820