Protein Alignment Irc and Duox2

DIOPT Version :9

• Sequence 1: NP_001262653.1
• Gene: Irc / 42049
• FlyBaseID: FBgn0038465
• Length: 697
• Species: Drosophila melanogaster
• Sequence 2: NP_001349684.1
• Gene: Duox2 / 214593
• MGIID: 3036280
• Length: 1545
• Species: Mus musculus
• Alignment Length: 575
• Identity: 157/575 - (27%)
• Similarity: 246/575 - (42%)
• Gaps: 91/575 - (15%)

  Fly   142 NSLKGNREGHYAFR-RLLGSSHYRNGFYQ-----MFPNSGRRETVPAAWSISKELYEPDHIQISK 200
            |:||.::.|....| |.|..::|.:|.||     :.||..|..               |.:...|
Mouse    43 NNLKYHQRGAAGSRLRRLIPANYADGVYQALEEPLLPNPRRLS---------------DAVAKGK 92

  Fly   201 QQTFESNSNLALPQWAQFVEHDLSKPVSQSMSNGAPIECCSRDQINLQPRHHHPACAPILYQPGG 265
            ......::...|..:  |..|.||..||.. :.|.|.|.     :|:    :.|...|: :.|..
Mouse    93 AGLPSVHNRTVLGVF--FGYHVLSDLVSVE-TPGCPAEF-----LNI----YIPRGDPV-FDPDK 144

  Fly   266 KYDVPSCLNYVRSALAVADCNFGGA-----EQLNQATGSLDLSQLYGFTAAAERKLRVLEGGLLR 325
            :.:|  .|.:.||..   |.|.|.:     :|.||.||.||.|.:||.:.:....||...||.|.
Mouse   145 RGNV--VLPFQRSRW---DHNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLA 204

  Fly   326 S-----TPRGEFDNALLPIATDTEGPSFCARATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHN 385
            |     .||....:.|:.:|.|   || ..|.  |....:|.|..|.|..||...:..::.|.||
Mouse   205 SGPDPAFPRNSQSSLLMWMAPD---PS-TGRG--GPQGVYAFGAQRGNREPFLQALGLLWFRYHN 263

  Fly   386 KVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQPNRALEVSNE 450
            ..|.:|.|.:|.|.||:|||.|:...:..|:.:.:.:|||..| ||...|....:|.....:|.|
Mouse   264 LCARKLAQEHPHWGDEELFQHARKRVIATYQNIALYQWLPSFL-QKTPPEYSGYRPFMDPSISPE 327

  Fly   451 FAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKE-------LPTKNLFELKEEIYKPK 508
            |.||:.:|..:|:|..         ||....:..:....||       |...|.:.::|   .|.
Mouse   328 FVVASEQFLSTMVPPG---------VYMRNSSCHFRKFPKEGSDSSPALRVCNSYWIRE---NPN 380

  Fly   509 LQYTSQKLNNILESLLNQETMKMDAAYSGGV--VWHKDTKPTHADILAFDIQRGRDHGLLPYYRY 571
            |: |:|.::.:|..:.:|.:...|......:  .|....:.:..|.:|..||||||.||..|.:.
Mouse   381 LK-TAQDVDQLLLGMASQISELEDRIVIEDLRDYWPGPERFSRTDYVASSIQRGRDMGLPSYSQA 444

  Fly   572 LESCVLSRPVESWKDFEHFIPSDVLDKLKTIY-ASWADVDLIVGGISENPVHGSIGPTFSCIISE 635
            |.:..| .|.::|......:...||:....:| ...:.::|::||:.|:  ||..||.||.||.:
Mouse   445 LLALGL-EPPKNWSALNPQVEPQVLEATAALYNQDLSQLELLLGGLLES--HGDPGPLFSNIILD 506

  Fly   636 QFVHVLK------QNQQKAVQKHTELVEQYRHFNGTKLLCLNSGL--SAVPQNIF 682
            |||.:..      :|.:..:....|:.| .|:.....:|...|.:  ||:..|:|
Mouse   507 QFVRLRDGDRYWFENTRNGLFSKEEIAE-IRNTTLRDVLVAVSNVDPSALQPNVF 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	148/552 (27%)
		An_peroxidase_like	290..637	CDD:265428	107/366 (29%)
Duox2	NP_001349684.1	dual_peroxidase_like	38..594	CDD:188652	157/575 (27%)
		EFh	824..885	CDD:238008
		EFh	861..919	CDD:238008
		Ferric_reduct	1085..1229	CDD:366815
		NOX_Duox_like_FAD_NADP	1271..1545	CDD:99783

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910