DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and pxn-1

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_505188.3	Gene:	pxn-1 / 191484	WormBaseID:	WBGene00004256	Length:	1285	Species:	Caenorhabditis elegans

Alignment Length:	787	Identity:	197/787 - (25%)
Similarity:	310/787 - (39%)	Gaps:	156/787 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YICLLAFIIGA----SLLTTIDANSSR----DVNAELNRIPASKWLQYVETALDSVNRQKRLEDN 62
            |.|:....:||    :.||.|...:.:    .::.||.|..|.|..|.||.|::...:|
Worm   477 YSCMAGNPVGAMSADAKLTVIGGETRKAAAPQIDEELLRAIAQKARQNVENAVEKTRKQ------ 535

  Fly    63 LLGSDITVKNGSLSHAQLLDTLPSLA---SK------KDNKLALKILKSSLLVFNSECLPNNIDG 118
             |..|.......|.......| |..|   ||      :..:|..:.::..|::...|..|.|:..
Worm   536 -LTQDKVTNTNDLKRLFRFST-PKQAVELSKAREIYEESVRLVREHVEKGLILNVDELHPKNVSY 598

  Fly   119 DK---------------CRSYLEQKPLPEG------SSLRTECENSLKG-NREGHYAFRRLLGSS 161
            :.               |.:...:.|..:.      .|...:|.|..|. ........|||| ..
Worm   599 ESVLHVTHVQALMGLSGCHTGQYKNPCTDTCFHHRYRSFDGQCNNKNKPMTGVSLMPLRRLL-KP 662

  Fly   162 HYRNGFYQMFPNSGRRETVPAAWSISKELYE----PDHIQISKQ----QTFESNSNLA--LPQWA 216
            .|.|||           ..|..|...: ||.    |:..::|:|    :....:|.|:  :.||.
Worm   663 VYENGF-----------NTPVGWEKGR-LYNGYPLPNVREVSRQLVATENITPHSKLSSMVMQWG 715

  Fly   217 QFVEHDLSKPVS----QSMSNGAPIECCSRDQINLQPRHHHPACA--PILYQPGGKYDVPSCLNY 275
            |||:|||:..|:    .|.:.||   .|:|...||.|..:.|...  |.:.....||   .|:.:
Worm   716 QFVDHDLTHTVTALSRHSYATGA---FCNRTCENLDPCFNIPLSPNDPRVKSGSAKY---PCIEF 774

  Fly   276 VRSALAVADCNFGGA----------EQLNQATGSLDLSQLYGFTAAAERKLR--VLEGGLLRSTP 328
            .|||   |.|..|..          ||:|..|..||.|.:||......::||  ....|:||...
Worm   775 ERSA---AVCGSGETSLVFNRVTYREQMNALTSFLDASNVYGSNEVQAQELRDTYNNNGMLRFDI 836

  Fly   329 RGEFDNALLPIATDTEGPSFCARATIGDG--TCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAEL 391
            ..|.....||...|:.  ..|.|....:.  .||.|||.|.|........:|||:|.||::|.:|
Worm   837 TSEAGKEYLPFEKDSN--MDCRRNFSEENPIRCFLAGDLRANEQLALAATHTIFIREHNRIAKKL 899

  Fly   392 KQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLG-----QKMSSEIRRKQPNRALEVSNEF 451
            |..|..|..|.::...:.:...:.:.:..:.|:|.:.|     .|.....:...|:....|:|.|
Worm   900 KSMNGNWDGEIIYHETRKIVGAMMQHITYKHWMPIIFGGQAQMNKFVGTYQGYDPDVDASVTNAF 964

  Fly   452 AVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTK-NLFELKEEIYKPKLQYTSQK 515
            |.||.||..:::...|..|..|                 .:|.| ....|.:..:.|:|..|...
Worm   965 ATAAFRFGHTIINPSLFRLGND-----------------FMPIKEGHIALHKAFFTPELVLTQGG 1012

  Fly   516 LNNILE-------------SLLNQETMKMDAAYSGGVVWHKDTKPTHADILAFDIQRGRDHGLLP 567
            ::.:|.             .|||.|.  ::..:..|   |:    ...|:...:|||.|||||..
Worm  1013 VDPLLRGLFASPLKHPMPTQLLNMEL--IEKLFMKG---HE----VSLDLAVMNIQRSRDHGLPS 1068

  Fly   568 YYRYLESCVLSRPVESWKDFEHFIPSD-VLDKLKTIYASWADVDLIVGGISENPV-HGSIGPTFS 630
            |..|.:.|.|..||: |:|.:.:|..| ::.||:.:|....::||.||||.|..: :|..||||:
Worm  1069 YTEYRKFCNLPVPVQ-WEDMKGYIKDDMIIQKLRGLYGVPQNIDLWVGGIVEEKLENGLFGPTFA 1132

  Fly   631 CIISEQFVHVLKQNQQKAVQKH----TELVEQYRHFNGTKLLCLN-SGLSAVPQNIFQLPSA-RN 689
            |||.||| ..::...:...:|.    .|.:.:.:.....:|.|.| ..:..:.:::|..|.. :.
Worm  1133 CIIGEQF-RKIRDGDRFWYEKDGVFTPEQLREIKKITLARLFCDNGDNIDRIQKDVFMYPGMDKE 1196

  Fly   690 QMVSCED 696
            ...:|::
Worm  1197 NYGTCQE 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	158/576 (27%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	106/381 (28%)
pxn-1	NP_505188.3	LRRNT	23..51	CDD:279764
		leucine-rich repeat	35..53	CDD:275380
		LRR_8	52..112	CDD:290566
		LRR_4	53..93	CDD:289563
		leucine-rich repeat	54..77	CDD:275380
		LRR_4	77..120	CDD:289563
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..117	CDD:275380
		LRR_8	123..182	CDD:290566
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		I-set	315..400	CDD:254352
		IGc2	328..392	CDD:197706
		IG_like	414..496	CDD:214653	5/18 (28%)
		Ig	420..496	CDD:299845	5/18 (28%)
		An_peroxidase	634..1181	CDD:281139	162/598 (27%)
		peroxidasin_like	757..1203	CDD:188658	126/481 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820