DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and C46A5.4

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_501272.2	Gene:	C46A5.4 / 177558	WormBaseID:	WBGene00016700	Length:	1537	Species:	Caenorhabditis elegans

Alignment Length:	765	Identity:	209/765 - (27%)
Similarity:	322/765 - (42%)	Gaps:	135/765 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LLTTIDANSSRDVNAELNRIPASKWLQYVETALDSVNRQ-KRLEDNLLGSDITVKNGSLSHAQLL 81
            ::...|..:.:| ..:|..:|.:|  :.||..:....|| :|.|:.         .|....|||.
Worm   742 IIQVFDPKAFKD-EEKLTSLPITK--ETVEKVIRLGLRQWQRYEEG---------EGRRISAQLS 794

  Fly    82 DTLPS--------LASKKDN----------KLALKILKSSLLVFNSECLPN-------------- 114
            |:.||        :|.||::          :.|..||.|...:...|.||:
Worm   795 DSSPSALLSHALLMAPKKESIDIARTASVLREATNILISGNGLDKDERLPDLDIGTLQKILPQID 859

  Fly   115 --NIDGDKCRSYLEQKPLPEGSSL--RTECE------------NSLKGNREGHYAF---RRLLGS 160
              ::.|: ...:|.:.|||:...|  ...|:            |:||..:.|: ||   ||||..
Worm   860 VGSVIGN-FTPFLARDPLPKEQCLPEPLPCDHTSKYRTYSGWCNNLKNPKFGN-AFTQMRRLLDP 922

  Fly   161 SHYRNGFYQMFPNSGRRETVPAAWSISKELYEPDHIQISKQQTFESNSNLALPQWAQFVEHD-LS 224
            : |.:||......|.....:|:|..||       :|..|....|.......|.|:.|.::|| :.
Worm   923 A-YDDGFDTPRTRSVLGSELPSARKIS-------NIVHSDAPKFHVKFTHMLMQFGQILDHDMMH 979

  Fly   225 KPVSQSMSNGAPIECCSRDQINLQPRHHHPACAPILYQPGGKY-------DVPSCLNYVRSALAV 282
            .|:|:...| ..:.|.|.|.......|    |.||..:....:       ..|.|:.:.||.|
Worm   980 SPISRGPKN-TILNCSSCDSAQTLSIH----CFPIKIEANDPFFPSKHSDGRPRCMPFARSLL-- 1037

  Fly   283 ADCNFGGAEQLNQATGSLDLSQLYGFTAAAERKLRVLEGGLLRSTPRGEFDNALLPIATDTEGPS 347
            |..:.|...||||.|..||.|.:||.|.....|||:...|.|..|..| |:...||.......
Worm  1038 AQVSLGFRNQLNQLTSFLDASTIYGSTQCEANKLRLFSDGKLNFTDLG-FNKEALPQGNQERD-- 1099

  Fly   348 FCARATIGD--GTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAV 410
              .|:.:.:  ..||.|||.|.|..|....|:.||:|.||::|..|||.|..||||||||.::.:
Worm  1100 --CRSVLQNRQRRCFVAGDERSNEQPGLTAIHNIFLREHNRIARYLKQINNFWSDEKLFQESRRI 1162

  Fly   411 NVDIYRRVVIEEWLPEVLG-QKMSSEIRRKQPNRALE---------VSNEFAVAAIRFYFSMLPN 465
            |:...:.::.:||||.||| |.|.......|.....|         :|.|.:.:|.||..|::..
Worm  1163 NIAQLQHIIYKEWLPVVLGCQNMEKWGLMPQTAGYFEGYDDQCDATISQEMSTSAFRFGHSLIRG 1227

  Fly   466 ELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKPKLQYTSQKLNNILESLLNQETMK 530
            ..           |..|:.:..::..:.....|.....:|    ...|..:.:||..|:...:|.
Worm  1228 VF-----------TRMNDNFQNMTNHVNLTETFSNPSPVY----DKNSGHMESILMGLIGANSMA 1277

  Fly   531 MDAAYSGGVVWHKDTKP----THADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFI 591
            .|......|..|...||    |..|:.|.:||||||||:..|..|.:.|.| |...::.|....:
Worm  1278 FDRHIVTAVRNHLFAKPGGPLTGLDLPAVNIQRGRDHGVQGYNAYRKHCGL-RKASAFSDLRDVM 1341

  Fly   592 PSDVLDKLKTIYASWADVDLIVGGISENPVHGS-IGPTFSCIISEQFVHVLK------QNQQKAV 649
            .|:.:..|:|.||...|:||..|.:||:|..|| :|||.:|:|.||...:.|      :.....|
Worm  1342 NSEAVTALETAYAHVDDIDLFPGIMSESPTRGSLVGPTLACLIGEQMQRLKKCDRFYYETSDSMV 1406

  Fly   650 QKHTELVEQYRHFNGTKLLCLNSGLSA-VPQNIFQLP-SARNQMVSCEDV 697
            :...:.:.:.|..:.::::|.||..:| :..|:|.:| ...|..::|.::
Worm  1407 RFTPDQLVEIRKASLSRIICDNSEYAANIQPNVFLMPDDLTNSPMTCSEL 1456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	162/554 (29%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	118/363 (33%)
C46A5.4	NP_501272.2	An_peroxidase	182..717	CDD:281139
		peroxinectin_like	334..712	CDD:188655
		An_peroxidase	894..1429	CDD:281139	166/571 (29%)
		peroxinectin_like	1045..1428	CDD:188655	123/403 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11475
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920