DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and mlt-7

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_494777.1	Gene:	mlt-7 / 173775	WormBaseID:	WBGene00022743	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	701	Identity:	181/701 - (25%)
Similarity:	298/701 - (42%)	Gaps:	155/701 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 TALDSVNRQKRLEDNLLGSDITVKNGSLSHAQLLDTLPSLASKKD-----NKLALKILKSSLLVF 107
            ::|.||...:|::|            |::.|..|.::..|.:..:     |.|::..:..|:
Worm   117 SSLTSVTSCERVKD------------SIAQASELMSISRLINPVEDNFGRNMLSIDDITRSV--- 166

  Fly   108 NSECLPNNID-GDKCRS----YLEQKPLPEGSSLRTECENSLKGNREGHYAFRRLLGSSHYRNGF 167
            .:.|:|...| |..||.    :|..:.| :|:     | |:|:...:| .||||          |
Worm   167 PTGCVPQLSDVGVDCRKSLCYHLMYRTL-DGT-----C-NNLEKPMQG-AAFRR----------F 213

  Fly   168 YQMFP---NSGRRETVPAAWSISKELYEPDHIQISK-QQTFESNSNLALPQWAQFVEHDLSKPVS 228
            .:.||   :.|:.|.:.:.........|.:.:.:|. |.......|..:.||.||:.||:||...
Worm   214 NRHFPAQYDDGKGEPISSLNQSRPSAREANRVMLSSAQSVVHDKFNNMMMQWGQFMSHDMSKTTL 278

  Fly   229 QSMSNGAPIECCSRDQINLQPRHHHPA-CAPILYQPGGKYDVPS-------CLNYVRSALAVADC 285
            |..:|     |.:.|.:        |: |.||   |.|:.| |:       ||...|||   ..|
Worm   279 QPSAN-----CKTCDPV--------PSKCMPI---PIGEKD-PNLGFKSKQCLKVSRSA---PIC 323

  Fly   286 NFGGAEQLNQATGSLDLSQLYGFTAAAERKLRVLEGGLLRSTPRGEFDNA-LLPIATDTEGPSFC 349
            .....||||:.|..:|.|.:||.:.....|.|....|.||.|   .|:|. :||.     ..|.|
Worm   324 RVEPREQLNENTAYIDGSMIYGSSLKDLHKFRDGRTGFLRVT---RFNNQNVLPF-----DQSKC 380

  Fly   350 A---RATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVN 411
            |   :.|    ..|.|||.|.|.......::.:|.|.||::|.:|.:.||.||.:::||.|:.:.
Worm   381 ANKDKCT----ASFTAGDIRANLFIGLSSLHIMFAREHNRIAQKLTELNPTWSGDRVFQEARKIV 441

  Fly   412 VDIYRRVVIEEWLPEVLG---QKMSSEIRRKQPNRALEVSNEFAVAAIRFYFSMLPN--ELLNLT 471
            ....:.|:.:|:||::||   .|:....:....|....::|||..:|.||...|:..  :.::|:
Worm   442 GAQIQNVLYKEYLPKLLGVSFDKVIGPYKGYDTNVDATIANEFTTSAFRFGHGMIEEFYKRVDLS 506

  Fly   472 KDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKPKLQYTSQKLNNILESLLNQETMKMDAAYS 536
            .:|:.:|.......||.|.::    |||...:........|:.|..:.:...:   |.||..:
Worm   507 GNNITHGGFFFGDGVFKSGKI----LFEGGVDPIIRGFMTTAVKRPHRMTPAI---TEKMFGS-- 562

  Fly   537 GGVVWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVLDK--- 598
                         .|:.:.:||||||||:..|.:..:.|.| :...::.||...|    ||:
Worm   563 -------------TDLGSLNIQRGRDHGIPSYNKMRQFCGL-KSANTFDDFADMI----LDRNLR 609

  Fly   599 --LKTIYASWADVDLIVGGISENPVHGS-IGPTFSCIISEQFVH-------------VLKQNQQK 647
              |...|.:..|||..||.:.|:||.|. :|.|.||.|.|||..             :..::|.:
Worm   610 AGLARNYNTTNDVDFYVGSMLEDPVIGGLVGTTLSCAIGEQFKRARDGDRFYFENPGIFTRSQME 674

  Fly   648 AVQKHTELVEQYRHFNGTKLLCLNS-GLSAVPQNIFQLPSARNQMVSCEDV 697
            .::|.:.          ::::|.|: ....|.|:.|.||.  :.:..|..:
Worm   675 EIKKSSL----------SRIICDNADNFELVSQDAFLLPG--SNLTPCSKI 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	149/560 (27%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	105/361 (29%)
mlt-7	NP_494777.1	ShK	41..76	CDD:279838
		An_peroxidase	191..691	CDD:281139	156/586 (27%)
		peroxinectin_like	328..688	CDD:188655	110/408 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820