DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and bli-3

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_490686.3	Gene:	bli-3 / 171608	WormBaseID:	WBGene00000253	Length:	1497	Species:	Caenorhabditis elegans

Alignment Length:	508	Identity:	126/508 - (24%)
Similarity:	216/508 - (42%)	Gaps:	88/508 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 SHYRNGFYQMFPNSGRRETVPAAWSISKELYEPDHIQISKQQTFESNS---NLALPQWAQFVEHD 222
            |:|.:|.|.:      ..::|:|..:|..|:        |.::...|:   ...|..::|.|.::
Worm    56 SYYSDGVYSV------NNSLPSARELSDILF--------KGESGIPNTRGCTTLLAFFSQVVAYE 106

  Fly   223 LSKPVSQSMSNGAPIECCSRDQINLQPRHHHPACAPIL-YQPGGKYDVPSCLNYVRSALAVADCN 286
            :.:      |||.   .|..:.:.:|.    |.|..:. .:..||.::|    :.|:....|..|
Worm   107 IMQ------SNGV---SCPLETLKIQV----PLCDNVFDKECEGKTEIP----FTRAKYDKATGN 154

  Fly   287 --FGGAEQLNQATGSLDLSQLYGFTAAAERKLRVLEGGLLRSTPRG--EFDNALLPIATDTEGPS 347
              ....||:|:.|..:|.|.:||.|......||..:.|.|.....|  ..:|..:|:  :...|.
Worm   155 GLNSPREQINERTSWIDGSFIYGTTQPWVSSLRSFKQGRLAEGVPGYPPLNNPHIPL--NNPAPP 217

  Fly   348 FCARATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNV 412
            ...|....| ..|..||||||.:|..:....|..|.||..|.::.:.:|.|:||::||||:.:.:
Worm   218 QVHRLMSPD-RLFMLGDSRVNENPGLLSFGLILFRWHNYNANQIHREHPDWTDEQIFQAARRLVI 281

  Fly   413 DIYRRVVIEEWLPEVLGQKMS-SEIRRKQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDN-V 475
            ...::::..:::|.:||:.:. |...:..|:....:|:.|..||.||..|::|..:|...:.| .
Worm   282 ASMQKIIAYDFVPGLLGEDVRLSNYTKYMPHVPPGISHAFGAAAFRFPHSIVPPAMLLRKRGNKC 346

  Fly   476 VYGTEKNNQYVF-----------ISKELPTKNLFELKEEIYKPKLQYTSQKLNNILESLLNQETM 529
            .:.||.......           |.||      :.:.|.|.....|...:..|.::|.|.:
Worm   347 EFRTEVGGYPALRLCQNWWNAQDIVKE------YSVDEIILGMASQIAERDDNIVVEDLRD---- 401

  Fly   530 KMDAAYSGGVVWHKDTKPTH---ADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDF-EHF 590
                 |..|        |.|   .|::|..|.||||:|:.||.....:..|:  .::|:.. |.|
Worm   402 -----YIFG--------PMHFSRLDVVASSIMRGRDNGVPPYNELRRTFGLA--PKTWETMNEDF 451

  Fly   591 IPSDV--LDKLKTIY-ASWADVDLIVGGISENPVHGSIGPTFSCIISEQFVHV 640
            .....  ::|||.:| .:...:|..|||:.|...:|. |..|..||.:||..:
Worm   452 YKKHTAKVEKLKELYGGNILYLDAYVGGMLEGGENGP-GELFKEIIKDQFTRI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	126/508 (25%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	98/368 (27%)
bli-3	NP_490686.3	An_peroxidase	28..542	CDD:281139	126/508 (25%)
		dual_peroxidase_like	31..586	CDD:188652	126/508 (25%)
		FRQ1	784..932	CDD:227455
		Ferric_reduct	1035..1176	CDD:280043
		NOX_Duox_like_FAD_NADP	1218..1402	CDD:99783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910