DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and Epx

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_031972.2	Gene:	Epx / 13861	MGIID:	107569	Length:	716	Species:	Mus musculus

Alignment Length:	794	Identity:	196/794 - (24%)
Similarity:	313/794 - (39%)	Gaps:	198/794 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLAFIIG--ASLLTT-------------IDANSSRDVNAELNRIPASKWLQYVETALDSVNRQKR 58
            ||| ::|  |:|:.|             ::.:..||..||...:        |:||.:  :.||.
Mouse     5 LLA-LVGALATLILTQHAEGTAPASPSPVEISVLRDCIAEAKLL--------VDTAYN--HTQKS 58

  Fly    59 LEDNLLGSDITVKNGSLSHAQLLDTL--PSLASKKDNK------LALKILKSSLLVFNSECLPNN 115
            :...|       ::||.|...||...  |..|:::..:      :||.:|:..|....|.  |.|
Mouse    59 IMQRL-------RSGSASPMDLLAYFKQPVAATRRVVQAADYMHVALGLLEERLQPRGSR--PFN 114

  Fly   116 IDGDKCRSYLEQKPLPEGSSLRTE---CENSLKG-----NREGH-------YAFRRLLGSSH--- 162
            .........|.......|.:|:.:   |.|..:.     |.:.|       .|..|.|.:.:
Mouse   115 ATDVLTEPQLRLLSQASGCALQDQAERCSNKYRTITGRCNNKKHPWLGASNQALARWLPAEYEDH 179

  Fly   163 -----------YRNGFYQMFPNSGRRETVPAAWSISKELYE-PDHIQISKQQTFESNSNLALPQW 215
                       .||||           .:|....:|.::.. |     ||:.|.:....|...||
Mouse   180 RSLPFGWTPGKRRNGF-----------LLPLVRDVSNQIVRFP-----SKKLTSDRGRALMFMQW 228

  Fly   216 AQFVEHDL----SKPVSQSMSNGAPIEC---CSRDQINLQPRHHHPACAPILYQPGGKYDVP--- 270
            .||::|||    ..|...:.|.|  ::|   |::          .|.|.||        .:|
Mouse   229 GQFIDHDLDFSPESPARVAFSMG--VDCEKTCAQ----------LPPCFPI--------KIPRND 273

  Fly   271 -------SCLNYVRSALAVADCNFGGAEQLNQATGSLDLSQLYG--FTAAAERKLRVLEGGLLRS 326
                   .|:.:.|||.|..........|:|..|..:|.|.:||  .|.|...:.|....|||.:
Mouse   274 PRIKNQRDCIPFFRSAPACPQNRNKVRNQINALTSFVDASMVYGSEVTLALRLRNRTNFLGLLAT 338

  Fly   327 TPRGEFDN--ALLPIATDTEGPSFCAR--ATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKV 387
            ..|.: ||  ||||.....|.|.....  |.|   .||.|||:|.:.:|....::|:|:|.||::
Mouse   339 NQRFQ-DNGRALLPFDNLHEDPCLLTNRSARI---PCFLAGDTRSSETPKLTALHTLFVREHNRL 399

  Fly   388 AAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRK-QPNRAL------ 445
            ||||::.||.||.:||:..|:.:...:.:.:...::||.|||:   :.|||. .|.|..
Mouse   400 AAELRRLNPHWSGDKLYNEARKIVGAMVQIITYRDFLPLVLGR---ARIRRTLGPYRGYCSNVDP 461

  Fly   446 EVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEEIYKP--- 507
            .|:|.|.: |.||..:||...:..|...   |.....|.:|      |..::|.....|...
Mouse   462 RVANVFTL-AFRFGHTMLQPFMFRLDSQ---YRASAPNSHV------PLSSVFFASWRIIHEGGI 516

  Fly   508 -----KLQYTSQKLNNILESLLNQETMKMDAAYSGGVVWHKDTKPTHADILAFDIQRGRDHGLLP 567
                 .|..|..|||       .|::|.:|....   ...:..:....|:.|.::||.|||||..
Mouse   517 DPILRGLMATPAKLN-------RQDSMLVDELRD---KLFQQVRRIGLDLAALNMQRSRDHGLPG 571

  Fly   568 YYRYLESCVLSRPVESWKDFEHFIPSDVLDKLKTIYASWADVDLIVGGISENPVHGS-IGPTFSC 631
            |..:...|.||:|....:........|:..|...:|.:..::|:.||.|:|..:.|: :||..:|
Mouse   572 YNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLRLYKTPDNIDIWVGAIAEPLLPGARVGPLLAC 636

  Fly   632 IISEQFVH-------------VLKQNQQKAVQKHTELVEQYRHFNGTKLLCLNSGLSAVPQNIFQ 683
            :...||..             |..:.|:||:          |..:.::::|.|:|::.|.::||:
Mouse   637 LFENQFRRARDGDRFWWQKWGVFTKRQRKAL----------RRISLSRIVCDNTGITTVSRDIFR 691

  Fly   684 LPSARNQMVSCEDV 697
            ........|||..:
Mouse   692 ANIYPQGFVSCSRI 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	151/594 (25%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	106/368 (29%)
Epx	NP_031972.2	An_peroxidase	146..684	CDD:281139	154/610 (25%)
Epx	NP_031972.2	myeloperoxidase_like	288..700	CDD:188656	122/448 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820