DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and epx

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	XP_002933592.2	Gene:	epx / 100496213	XenbaseID:	XB-GENE-6039946	Length:	716	Species:	Xenopus tropicalis

Alignment Length:	741	Identity:	185/741 - (24%)
Similarity:	300/741 - (40%)	Gaps:	164/741 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RIPASKWLQYVETALDSVNRQKRLEDNLLGS---------DITVKNGSLSHAQLL--------DT 83
            :|.||.:...||          .|::||:.|         ||..||..|...:.|        |.
Frog    18 QITASSYYDGVE----------ELDNNLILSCTKEAKHLVDIAYKNTRLMLKERLRKRTVSASDL 72

  Fly    84 L-----PSLASKKDNKLA------LKILKSSLLVFNSECLPNNIDGDKCRSYLE---------QK 128
            :     |...|:...:.|      |::|...|..|:..  |.||......:.::         .:
Frog    73 MAYFKQPVAGSRNAIRAADYMGTTLQLLSKKLQPFHHR--PFNITDLLTETQIDTIYKLTGCAYQ 135

  Fly   129 PLP---EGSSLRT---ECENS----LKGNREGHYAFRRLL------GSSHYRNGFYQMFPNSGRR 177
            .||   :.|:.||   ||.|.    |..:..|   |.|||      |.|..| |:.:..|.:|
Frog   136 HLPRACQESTYRTITGECNNRKNPILGASNTG---FTRLLPAVYEDGVSLPR-GWTENLPING-- 194

  Fly   178 ETVPAAWSISKELYE-PDHIQISKQQTFESNSNLALPQWAQFVEHDL----SKPVSQSMSNGAPI 237
            ..:|.|.::|.|:.. |     ::..|.:....|...||.|:.:|||    ..|...:...|  |
Frog   195 FPLPLARAVSNEIVRFP-----NENLTLDQGRALIFMQWGQWTDHDLDLSPETPARSTFLEG--I 252

  Fly   238 EC---CSRDQINLQPRHHHPACAPILYQPGGK--YDVPSCLNYVRSALAVADCNFGG--AEQLNQ 295
            :|   |::          .|.|.|:...|...  .:...|:...||:..   |..|.  .||:|.
Frog   253 DCDTSCAK----------QPPCFPLKIPPNDPRIRNQSDCIPLFRSSPV---CTPGSPVREQINV 304

  Fly   296 ATGSLDLSQLYGFTAAAERKLR--VLEGGLLRSTPRGEFDNAL--LPIATDTEGPSFCARATIGD 356
            .|..||.||:||.......|||  ..:.||:....:.. ||.|  ||..|..|  .||.......
Frog   305 LTSFLDGSQVYGSDWPLAVKLRNNTNQLGLMAINQKFT-DNGLPFLPFETAEE--DFCVLTNRSS 366

  Fly   357 G-TCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVI 420
            | .||..||.||:..|.....:|:|:|.||.:|..|::.|||||.|.|:|.|:.:...|.:::..
Frog   367 GIPCFLGGDPRVSEQPGLTAFHTLFVRAHNNIATRLRELNPRWSGETLYQEARKIVGGILQKITY 431

  Fly   421 EEWLPEVLGQKMSSEI---RRKQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKN 482
            ::|||.:||.:|::.:   |....|....|:|.|.| ..|...:::...:..|..     |....
Frog   432 KDWLPLLLGSEMATVLPAYRSYNENVDPRVANVFTV-VFRMGHTLIQPFIYRLAD-----GYRPL 490

  Fly   483 NQYVFISKELPTKNLFE-LKEEIYKPKLQ---YTSQKLNNILESLLNQETMKMDAAYSGGVVWHK 543
            |....:...:...|.:. ::|....|.|:   ....|||...:.::::...::...:
Frog   491 NPEPRVPLHMTFFNSWRVVREGGIDPLLRGLMANRAKLNRQNQLVVDELRERLFVLF-------- 547

  Fly   544 DTKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIP----SDVLDKLKTIYA 604
              |....|:.|.::||||:|||..|..:...|.||.|    ::.:....    ..:.:|...:|.
Frog   548 --KRIGLDLTAINMQRGREHGLPGYNAWRRFCGLSAP----RNVDELAAVLNNRGLAEKFVKLYG 606

  Fly   605 SWADVDLIVGGISENPV-HGSIGPTFSCIISEQFVH------------VLKQNQQKAVQKHTELV 656
            :..::|:.|||::|:.| :|.||...:|:|..||..            .:..|.|:|..:...|
Frog   607 TPENIDIWVGGVAESLVRNGRIGKLLTCLIGNQFRRARDGDRFYYEQPTVFTNAQRASIERVTL- 670

  Fly   657 EQYRHFNGTKLLCLNSGLSAVPQNIF 682
                    .:::|.|:.::.||:|:|
Frog   671 --------ARVICDNTKITEVPRNVF 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	144/567 (25%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	100/363 (28%)
epx	XP_002933592.2	myeloperoxidase_like	288..697	CDD:188656	115/436 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010