DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and mpo

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	XP_002935236.4	Gene:	mpo / 100490938	XenbaseID:	XB-GENE-482502	Length:	725	Species:	Xenopus tropicalis

Alignment Length:	760	Identity:	185/760 - (24%)
Similarity:	315/760 - (41%)	Gaps:	144/760 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IIGA---SLLTTIDANSSRDVNAELNRIPASKWLQYVETALD---SVNRQKRLEDNLLGSDITV- 70
            |:|:   ||.:..|.....|.:..||.:..:|.|  |:||..   .|.:.:..:.|:..||:..
Frog    13 ILGSVHVSLSSFYDGVEELDNDIILNSVQEAKKL--VDTAYKRTRDVLKARLKQKNVRPSDVMAF 75

  Fly    71 ----KNGSLSHAQLLD----TLPSLASKKDNKLALKILKSSLLVFNSECLPNNIDGDKCRSYLEQ 127
                ...|.:|.:..|    ||..|:.|..:........:.:|..|.......:.|  |......
Frog    76 FKQPVATSRTHIRAADYMGTTLELLSEKIQSVYRRPFNITDVLTANQLDTIYKVSG--CAFLHLS 138

  Fly   128 KPLPEGSSLRT---ECENSLKGN-REGHYAFRRLL------------GSSHYR--NGFYQMFPNS 174
            :|.| .|..||   ||.|....| ...:..:.|||            |.:..|  |||
Frog   139 RPCP-NSRYRTFTGECNNRRFPNFGVSNRPYTRLLPAQYEDSRSLPRGWTENRRINGF------- 195

  Fly   175 GRRETVPAAWSISKELYE-PDHIQISKQQTFESNSNLALPQWAQFVEHDL----SKPVSQSMSNG 234
                .:|.|.::|.::.: |:     ::||.::..:|...||.|:::||:    ..|...|...|
Frog   196 ----MLPLARAVSNQILQFPE-----REQTLDNQRSLMFMQWGQWIDHDVDLAPETPARSSFLKG 251

  Fly   235 APIEC---CSRDQINLQPRHHHPACAPILYQPGGK--YDVPSCLNYVRSALAVADCNFGGA-EQL 293
              |:|   |:::.          .|.|:...|...  .:...|:...||:.|   |..|.. ||:
Frog   252 --IDCDHSCAKEL----------PCFPLRIPPNDPRIQNRSDCIPLFRSSPA---CVPGPVLEQI 301

  Fly   294 NQATGSLDLSQLYGFTAAAERKLRVLEGGLL-------RSTPRGEFDNAL--LPIATDTEGPSFC 349
            |..|..:|.||:||.|....|.||....|.|       |.|     |..|  ||.:|..|  .||
Frog   302 NVLTSYVDASQVYGSTNDLARMLRNNTAGQLGLMAVNTRFT-----DGGLPYLPFSTMKE--DFC 359

  Fly   350 ARATIGDG-TCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVD 413
            .......| .||.|||:||:..|.....:|||:|.||::|.||::.||.|:.|.:||.|:.:...
Frog   360 VLTNETSGLPCFLAGDARVSEQPGLTAFHTIFVREHNRIARELRRINPNWTGEIIFQEARKIVGA 424

  Fly   414 IYRRVVIEEWLPEVLGQKMSSEIRRKQP-NRALE--VSNEFAVAAIRFYFSMLPNELLNLTKDNV 475
            :.:::..:::||.:||..|...:.|... |.::.  .||.|:: ..|...:|:...:..|
Frog   425 VEQKINYKDYLPLLLGSSMPRVLPRYTTYNDSVNPGASNVFSL-VFRMGHTMIQPFIFRL----- 483

  Fly   476 VYGTEKNNQYVFISKELPTKNLFE-LKEEIYKPKLQ---YTSQKLNNILESLLNQETMKMDAAYS 536
            |.|...::....:...|...|.:. :.|....|.|:   ....|||...:.|:.|.|..:...:
Frog   484 VDGYRASSSLPPVPLHLTFFNTWRVILEGGVDPLLRGLIANKAKLNTQTQILVTQLTDHLFELF- 547

  Fly   537 GGVVWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFIPSDVLDKLKT 601
                     |....|:.|.::||||||||..|..:...|.||:|....:.......:.:..||.:
Frog   548 ---------KRLGLDLGAINMQRGRDHGLPGYNAFRRLCGLSQPRNESELAAVLRNNQLAQKLIS 603

  Fly   602 IYASWADVDLIVGGISENPV-HGSIGPTFSCIISEQF-------------VHVLKQNQQKAVQKH 652
            :|.:..::|:.:|.::|..: :|.:|...:|:|.:||             ..|....|.:::::.
Frog   604 LYGTPDNIDIWMGAVAEPLITNGRVGELLACLIGDQFRRTRDGDRFYYERASVFTPAQLRSIERA 668

  Fly   653 TELVEQYRHFNGTKLLCLNSGLSAVPQNIFQLPSARNQMVSCEDV 697
            :.          .:::|.|:.::.||:::|:..:.....|.|..:
Frog   669 SL----------ARIVCDNTRITEVPRDVFKANNYPANFVRCSSI 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	142/576 (25%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	102/365 (28%)
mpo	XP_002935236.4	An_peroxidase	146..688	CDD:397287	151/605 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010