DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and duox2

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	XP_017947900.2	Gene:	duox2 / 100486050	XenbaseID:	XB-GENE-6047411	Length:	1517	Species:	Xenopus tropicalis

Alignment Length:	582	Identity:	141/582 - (24%)
Similarity:	234/582 - (40%)	Gaps:	95/582 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 YRNGFYQM--FPNSGRRETVPA-----AWSISKELYEPDHIQISKQQT-----FESNSNLALPQW 215
            |.|..|..  .|.|.....:||     .:.:.||...|:...||...|     ..|:.||.: ..
Frog    33 YNNLAYHSTGSPGSKLLRHIPAFYTDGVYQVPKEPELPNPRSISNVVTKGKSGLPSSRNLTV-MA 96

  Fly   216 AQFVEHDLSKPVSQSMSNGAPIECCSRDQINLQ-PR------HHHPACAPILYQPGGKY-DVPSC 272
            ..|..|.||:.|    ..|.|  .|..:.:|:: |:      ..:.:...|.:|....| |....
Frog    97 ISFGYHVLSEVV----YTGKP--ACPAEFLNIEIPKGDLVFDRTNTSKVVIPFQRSKWYPDTGRS 155

  Fly   273 LNYVRSALAVADCNFGGAEQLNQATGSLDLSQLYGFTAAAERKLRVLEGGLLRSTP-RG--EFDN 334
            .|..|             :.:|..:..:|.|.:||.:.:....||...||.|.|.| .|  .|..
Frog   156 PNNPR-------------DHVNSVSAWIDGSSIYGSSHSWCDALRNFSGGKLASGPDEGVPRFAK 207

  Fly   335 ALLPIATDTEGPSFCARATIGDGTCFAAGDSRVNSSPFSILIYTIFMRNHNKVAAELKQRNPRWS 399
            :.||: .....||   ....|:...:|.|::|.|.|||...:..::.|.||..|.|..:.||.||
Frog   208 SDLPM-WKVPNPS---TGETGNNGLYAFGNARANESPFLQSLGILWFRYHNYKAQEFAKENPEWS 268

  Fly   400 DEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQKMSSEIRRKQPNRALEVSNEFAVAAIRFYFSMLP 464
            ||.|||.|:...:.:|:.:|..||||..|.:.::: .:..|.:....:|..|.|...:..::|:|
Frog   269 DEVLFQHARKWVIAVYQNIVFYEWLPAFLSRNVTA-YKGYQQHVDPSISPVFTVQLSQMIYTMMP 332

  Fly   465 NELLNLTKDNVVYGTEKNNQYVFISKEL-------PTKNL--FELKEEIYKPKLQYTSQKLNNIL 520
            :.:....||........:|..|:.:..|       ...||  ....:||........::|.:||
Frog   333 SGIYMRNKDCNFQNVSGSNGSVWPALRLCNNYWNRENSNLKNSSSTDEILMGMASQIAEKEDNI- 396

  Fly   521 ESLLNQETMKMDAAYSGGVVWHKDTKPTHADILAFDIQRGRDHGLLPYYRYLE--SCVLSRPVES 583
              |:|..|   |..|.       ..|.:..|:.|..|...||.||..|.:..|  .|.|   :|:
Frog   397 --LVNDLT---DYCYG-------QIKYSRTDLFAASILHARDLGLPNYNKVCEYYQCPL---LEN 446

  Fly   584 WKDFEHFIPSDVLDKLKTIYASWAD-VDLIVGGISENPVHGSIGPTFSCIISEQFVHVLK----- 642
            |   |.....::..||.::|.:..: ::.|.|.::|  :.|:....||.|:.|||..:..
Frog   447 W---EKMTDKELGKKLASLYGNDTEKLEFIPGLLAE--MAGNSINFFSDIVLEQFYRLRDGDRFW 506

  Fly   643 -QNQQKAV--QKHTELVEQYRHFNGTKLLCLNSGLSAVPQNIFQL----PSARNQMVSCEDV 697
             :|.:..:  :|..:.:...:..|  .|:.:......:.||:|.|    |..:.:.:..|::
Frog   507 FENVKNGLFSKKDIDNIRNIKLQN--VLVAVTDAGDTIQQNVFFLKEDDPCPQPKQLQSEEL 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	135/551 (25%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	97/361 (27%)
duox2	XP_017947900.2	dual_peroxidase_like	29..581	CDD:188652	141/582 (24%)
		FRQ1	726..918	CDD:227455
		PLN02292	1056..>1376	CDD:215165
		NOX_Duox_like_FAD_NADP	1244..1517	CDD:99783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910