DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irc and pxdn

DIOPT Version :9

Sequence 1:	NP_001262653.1	Gene:	Irc / 42049	FlyBaseID:	FBgn0038465	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	XP_009291604.1	Gene:	pxdn / 100332937	-ID:	-	Length:	1468	Species:	Danio rerio

Alignment Length:	820	Identity:	189/820 - (23%)
Similarity:	319/820 - (38%)	Gaps:	229/820 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GIQYICLLAFIIG---ASLLTTIDA-NSSRD----VNAELNRIPASKWLQYVETALDSVNRQ--- 56
            |.:|.|:....||   :|::.|:.. ..||:    |:..|...     ::.:.:|:||..||
Zfish   584 GGRYECVARNSIGYSSSSMVLTVQVPQVSREGDPFVSTSLEEA-----IRSINSAIDSTRRQLFD 643

  Fly    57 ----------------------------KRLEDNLLGSDITVKNG-------------SLSHAQL 80
                                        :..|..||.....|..|             .|...:.
Zfish   644 GSPRTPAELLALFRYPRDPYTVEQARAGEIFEQTLLLIQRHVNQGLMVDTNGTAYRYNDLVSPRF 708

  Fly    81 LDTLPSL----ASKKDNKLALKILKSSLLVFNSECLPNNIDGDKCRSYLEQKPLPEGSSLRTECE 141
            ||.:.:|    |.::.|..:...........:..|  ||:          |.|: .|:|| |..|
Zfish   709 LDMIANLSGCTAHRRINNCSDICFHQKYRTHDGTC--NNL----------QHPM-WGASL-TPFE 759

  Fly   142 NSLKGNREGHYAFRRLLGSS-HYRNGFYQMFPNSGRRETVPAAWSISKELYEPD----HIQISKQ 201
            ..||...:..:...|  |:: .:.||:....|.      :.:...|..|...||    |:
Zfish   760 RLLKPVYDNGFNLPR--GTTERWHNGYPLPLPR------LVSTTMIGTETITPDDRYTHM----- 811

  Fly   202 QTFESNSNLALPQWAQFVEHDL-SKPVSQSMSNGAPIECCSRDQINLQPRHHHPACAPILYQPGG 265
                      |.||.||::||| |..||.|.|..:..:.|:....|      .|.|.||::.|..
Zfish   812 ----------LMQWGQFLDHDLDSTVVSLSQSRFSDGQLCTSVCTN------DPPCFPIMFPPND 860

  Fly   266 ---KYDVPSCLNYVRSALAVADCNFG----------GAEQLNQATGSLDLSQLYGFTAAAERKLR 317
               :.:...|:.:|||:..   |..|          ..||:||.|..:|.|.:||.:.....::|
Zfish   861 PRQRRNGARCMFFVRSSPV---CGSGMTSLLMNSVYPREQMNQLTSYIDASNVYGSSQHEAEEIR 922

  Fly   318 VLEG--GLLRSTPRGEFDNALLPIATDTEGPSFCAR----ATIGDGTCFAAGDSRVNSSPFSILI 376
            .|..  |:||..........|||.||..  |:.|.|    :.|   .||.|||.|.|.......:
Zfish   923 DLASHRGMLRQGIVQRTGKPLLPFATGP--PTECMRDENESPI---PCFLAGDHRANEQLGLTAM 982

  Fly   377 YTIFMRNHNKVAAELKQRNPRWSDEKLFQAAKAVNVDIYRRVVIEEWLPEVLGQ---KMSSEIRR 438
            :|:::|.||::|:||.:.||.|..:.::..|:.:.....:.:...:|||::||:   ::..:...
Zfish   983 HTVWLREHNRIASELLRLNPHWDGDTIYHEARKIVGAQMQHITYNQWLPKILGEAGMRIMGDYTG 1047

  Fly   439 KQPNRALEVSNEFAVAAIRFYFSMLPNELLNLTKDNVVYGTEKNNQYVFISKELPTKNLFELKEE 503
            ..||....:.|.||.||.||..:::         :.::|..::|.|.:       .:....|.:.
Zfish  1048 YNPNINAGILNAFATAAFRFGHTLI---------NPILYRLDENFQPI-------QQGHISLHKA 1096

  Fly   504 IYKP---------------------KLQYTSQKLN-NILESLLNQETMKMDAAYSGGVVWHKDTK 546
            .:.|                     |::.::|.|| .:.|.|.:.
Zfish  1097 FFSPFRIVNEGGIDPLLRGLFGVAGKMRMSTQLLNTELTERLFSM-------------------- 1141

  Fly   547 PTHA---DILAFDIQRGRDHGLLPYYRYLESCVLSRPVESWKDFEHFI--PSDVLDKLKTIYASW 606
             .||   |:.|.:||||||||:..|..|...|.|: ..::::|.::.|  || |.:||:.:|.:.
Zfish  1142 -AHAVALDLAAMNIQRGRDHGIPSYNDYRVFCNLT-SAQTFEDLKNEIQNPS-VREKLQRLYGTP 1203

  Fly   607 ADVDLIVGGISENPVHGS-IGPTFSCIISEQFVHVLKQNQ------------QKAVQKHTELVEQ 658
            .:|||....::|..|.|| :|||..|:::.||..:...::            |....|.|.|
Zfish  1204 LNVDLFPALMAEELVPGSRLGPTLMCLLATQFKRLRDGDRFWYENPGSFSPAQLTQLKQTSL--- 1265

  Fly   659 YRHFNGTKLLCLN-SGLSAVPQNIFQLPSARNQMVSCEDV 697
                  :::||.| ..::.:..:.|.:....:...||.|:
Zfish  1266 ------SRVLCDNGDNITRIQSDAFSVADLPHGYGSCADL 1299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irc	NP_001262653.1	An_peroxidase	151..672	CDD:281139	146/589 (25%)
Irc	NP_001262653.1	An_peroxidase_like	290..637	CDD:265428	101/383 (26%)
pxdn	XP_009291604.1	LRRNT	31..57	CDD:214470
		leucine-rich repeat	59..106	CDD:275378
		LRR_4	105..146	CDD:289563
		LRR_8	106..165	CDD:290566
		leucine-rich repeat	107..130	CDD:275378
		LRR_4	130..168	CDD:289563
		leucine-rich repeat	131..154	CDD:275378
		leucine-rich repeat	155..178	CDD:275378
		leucine-rich repeat	179..191	CDD:275378
		LRRCT	187..238	CDD:214507
		Ig	241..328	CDD:299845
		I-set	241..328	CDD:254352
		Ig	341..424	CDD:299845
		IG_like	343..424	CDD:214653
		I-set	428..514	CDD:254352
		Ig	441..514	CDD:299845
		I-set	520..606	CDD:254352	6/21 (29%)
		Ig	537..605	CDD:299845	6/20 (30%)
		An_peroxidase	736..1277	CDD:281139	158/639 (25%)
		peroxidasin_like	857..1296	CDD:188658	118/494 (24%)
		VWC	1410..1461	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	1	1.000	-	-		FOG0000202
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920