DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3a1 and sf3a1

DIOPT Version :9

Sequence 1:	NP_650583.1	Gene:	Sf3a1 / 42048	FlyBaseID:	FBgn0266917	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_956388.1	Gene:	sf3a1 / 796388	ZFINID:	ZDB-GENE-030616-156	Length:	780	Species:	Danio rerio

Alignment Length:	823	Identity:	432/823 - (52%)
Similarity:	539/823 - (65%)	Gaps:	114/823 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DQPKS---MSGPIIGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNELGNPKFNFLNGGDPYH 77
            ::||.   .:.||:|||||||||||||||||||||||||||||||||||:.||||||||..||||
Zfish    18 EEPKEETPATKPIVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPSDPYH 82

  Fly    78 AYYRHKVNEFREGNDAGITALASMKQLAVTSAAQQRQ---QELLKQVVEQQFVPKEPPPEFEFIA 139
            ||||||||||:||.       |.....||....|..|   |::..||:.:..|||||||||||||
Zfish    83 AYYRHKVNEFKEGK-------AQEPSAAVPKVMQHPQQLPQKVQAQVIHETVVPKEPPPEFEFIA 140

  Fly   140 DPPSISALDLDIVKLTAQFVARNGRQFLTNLMSREQRNFQFDFLRPQHSLFQYFTKLLEQYTKVL 204
            |||||||.|||:|||||||||||||||||.||.:||||:||||||||||||.|||||:|||||||
Zfish   141 DPPSISAFDLDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKVL 205

  Fly   205 IPPKDLLGKLRSESAPGRSSMNQVLEQVKYRANWQRHQEAQRRREEEKIERERVAYAQIDWHDFV 269
            ||||.||.||:.|:...|    :||:||:||..|.:.||.:|::|||:.|:||||||||||||||
Zfish   206 IPPKGLLLKLKKEAENPR----EVLDQVRYRVEWAKFQERERKKEEEEREKERVAYAQIDWHDFV 266

  Fly   270 VVETVDYQPFESGNFPPPTNPDEVGARVLMEERL--MDEEGDTEMQIESDDEGDSQANNLLDSGL 332
            ||||||:||.|.|||||||.|:|:|||:|::||.  ..|..:.||::||:||.|
Zfish   267 VVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEVESEDEDD----------- 320

  Fly   333 KLSQMENRVGIQMKNVSSYGQPTGPKRDNTQVQDMDEAS-SDEDTPTTKLQPS--VAPMLPPTHD 394
               :.|.|         ..|....|.:| ||:|||||.| .|:|.....|.|.  :.|.||||.|
Zfish   321 ---EREGR---------EDGHAAQPDQD-TQLQDMDEGSDEDDDGMKAPLPPDNPLPPPLPPTPD 372

  Fly   395 KVVVKK-YDPKATQPKQAPMPT-DEYLISPITGEKIPASKVSEHMRIGLLDPRWVEQRDKHTVEK 457
            :|:::| |||||::| .||:.| |||||||||||||||||:.||||||||||||:||||:...|:
Zfish   373 QVIIRKDYDPKASKP-LAPVATPDEYLISPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIRER 436

  Fly   458 INQDNVFAAGTAIEASLKQLAERRTDIFGVGDEETVIGKKLGEEETKK-DDRVTWDGHTSSVEAA 521
            ..::.|:|.|..||:|||||||||||||||  |||.||||:||||.:| :::||||||:.|:...
Zfish   437 QIEEEVYAPGLDIESSLKQLAERRTDIFGV--EETAIGKKIGEEEIQKPEEKVTWDGHSGSMART 499

  Fly   522 TRAARANITLEEQIHQIHKVKGLL-PDEEKEKIGP-KPVGNKATLSAPPQPSTKSQHSHSSQSQH 584
            .:||:|||||:|||..|||.|||: .|:.|||||| ||  |:  :..||.||........:.
Zfish   500 QQAAQANITLQEQIEAIHKAKGLVQEDDSKEKIGPSKP--NE--VPQPPMPSIPPSMPKPAP--- 557

  Fly   585 HQGGGGGHHGHHNPHHHHPPHQQAPPHQSHHHHPPQQP----QPVMQLMQLRP----TMMQPPFG 641
                         |.:...|...|||.::  ...|..|    .||..:::|.|    ..|.|...
Zfish   558 -------------PMNIPRPTSMAPPVRT--TLLPAVPVIPRPPVASVVRLAPGQVLAPMPPMLH 607

  Fly   642 AGGGGYMNMQPGG------------IPQQIAPAPPV-----------------DIMEEEPPSKKI 677
            |.....:.|.|.|            :|....|||||                 ...|:||.|||:
Zfish   608 APRINVVPMPPSGPHIMAPRPPPMVVPAAFVPAPPVPQPPSAVSAPMPPAHPPPPHEDEPSSKKM 672

  Fly   678 RSEDNLIPEADFIATHKSPVTIQVLVPN-SDKSEWKLNGQMIAVTMALSEPIANLKTKLQDETGM 741
            ::|||||.|.:|:..:|.||.::|.||| .||:||||:||::...:.|::.::.:|.|:.:.|||
Zfish   673 KTEDNLIAEDEFLRRNKGPVAVKVQVPNMQDKTEWKLSGQVLNFNLPLTDQVSVIKVKIHEATGM 737

  Fly   742 PPAKQKIFYEGMFFKDSNTMAFYNLVNGTTVHLQVKERGGRKK 784
            |..|||:.|||:|.||||::|:||:.||..:||.:||||||||
Zfish   738 PAGKQKLQYEGIFIKDSNSLAYYNMNNGAVIHLALKERGGRKK 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3a1	NP_650583.1	SWAP	36..89	CDD:197818	48/52 (92%)
		Surp	150..200	CDD:280053	42/49 (86%)
		PRP21_like_P	227..479	CDD:289034	138/258 (53%)
		SF3a120_C	709..784	CDD:176395	37/74 (50%)
		UBQ	713..777	CDD:214563	28/63 (44%)
sf3a1	NP_956388.1	SWAP	41..94	CDD:197818	48/52 (92%)
		Surp	151..201	CDD:307771	42/49 (86%)
		PRP21_like_P	218..459	CDD:315004	141/269 (52%)
		SF3a120_C	705..780	CDD:176395	37/74 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590686
Domainoid	1	1.000	253	1.000	Domainoid score	I2036
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4294
Inparanoid	1	1.050	751	1.000	Inparanoid score	I548
OMA	1	1.010	-	-		QHG55212
OrthoDB	1	1.010	-	-		D1256232at2759
OrthoFinder	1	1.000	-	-		FOG0003484
OrthoInspector	1	1.000	-	-		oto39484
orthoMCL	1	0.900	-	-		OOG6_102246
Panther	1	1.100	-	-	LDO	PTHR15316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1278
SonicParanoid	1	1.000	-	-		X3377
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.900