DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3a1 and sf3a1

DIOPT Version :9

Sequence 1:	NP_650583.1	Gene:	Sf3a1 / 42048	FlyBaseID:	FBgn0266917	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	XP_017945285.1	Gene:	sf3a1 / 734097	XenbaseID:	XB-GENE-6086860	Length:	811	Species:	Xenopus tropicalis

Alignment Length:	846	Identity:	435/846 - (51%)
Similarity:	548/846 - (64%)	Gaps:	136/846 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EQFGNDQPKSM--SGPIIGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNELGNPKFNFLNGG 73
            ||...::.:.:  |.|::|||||||||||||||||||||||||||||||||||:.||||||||..
Frog    30 EQMEEEKKEEVVPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPN 94

  Fly    74 DPYHAYYRHKVNEFREGNDAGITALASMKQLAVTSAAQQRQQELLKQVVEQQFVPKEPPPEFEFI 138
            ||||||||||||||:||. |...:.|..|.:....:.||..|::..|||::..||||||||||::
Frog    95 DPYHAYYRHKVNEFKEGK-AQEPSAAIPKVMQQQQSVQQLPQKVQAQVVQETIVPKEPPPEFEYV 158

  Fly   139 ADPPSISALDLDIVKLTAQFVARNGRQFLTNLMSREQRNFQFDFLRPQHSLFQYFTKLLEQYTKV 203
            ||||||||.|||:|||||||||||||||||.||.:||||:||||||||||||.|||||:|||||:
Frog   159 ADPPSISAFDLDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKI 223

  Fly   204 LIPPKDLLGKLRSESAPGRSSMNQVLEQVKYRANWQRHQEAQRRREEEKIERERVAYAQIDWHDF 268
            |||||.||.||:.|:    .:..:||:||:||..|.:.||.::::|||:.|||||||||||||||
Frog   224 LIPPKGLLVKLKKEA----ENPTEVLDQVRYRVEWAKFQEREKKKEEEEKERERVAYAQIDWHDF 284

  Fly   269 VVVETVDYQPFESGNFPPPTNPDEVGARVLMEERL--MDEEGDTEMQIESDDEGDSQANNLLDSG 331
            |||||||:||.|.|||||||.|:|:|||:|::||.  ..|..:.||::|||||.:.:.|...||.
Frog   285 VVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEVESDDEDEVKNNKAEDSS 349

  Fly   332 LKLSQMENRVGIQMKNVSSYGQPTGPKRDNTQVQDMDEASSDEDTPTTKLQPSVAPM---LPPTH 393
               |||:                     .:||||||||.|.||:..:....|..:||   ||||.
Frog   350 ---SQMD---------------------QDTQVQDMDEGSDDEEYTSKAPLPPESPMPPPLPPTP 390

  Fly   394 DKVVVKK-YDPKATQP-KQAPMPTDEYLISPITGEKIPASKVSEHMRIGLLDPRWVEQRDKHTVE 456
            |:|:|:| |||||::| ..||.| ||||:||||||||||||:.||||||||||||:||||:...|
Frog   391 DQVIVRKDYDPKASKPLPPAPAP-DEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRAIRE 454

  Fly   457 KINQDNVFAAGTAIEASLKQLAERRTDIFGVGDEETVIGKKLGEEETKK-DDRVTWDGHTSSVEA 520
            |...|.|:|.|..||:|||||||||||||||  |||.||||:||||.:| :::||||||:.|:..
Frog   455 KQGDDEVYAPGLDIESSLKQLAERRTDIFGV--EETAIGKKIGEEEIQKPEEKVTWDGHSGSMAR 517

  Fly   521 ATRAARANITLEEQIHQIHKVKGLLPDEE-KEKIGP-KPVGNKATLSAPPQPSTKSQHSHSSQSQ 583
            ..:||:|||||:|||..|||.|||:|:|: |:|||| ||  |:  :|.||..:.....|
Frog   518 TQQAAQANITLQEQIEAIHKAKGLVPEEDGKDKIGPSKP--NE--MSQPPSSAPTIPTS------ 572

  Fly   584 HHQGGGGGHHGHHNPHHHHPPHQQAPPHQSHHH-------HPPQQPQPVMQLM-QLRPTMMQPPF 640
                              .||....|....||.       .||..|.|:...| ...|.|.:||.
Frog   573 ------------------APPISSVPRPMPHHQQMTSQVSRPPTMPPPIRTTMVSAVPVMQRPPM 619

  Fly   641 GAGGGGYMNMQPGG------------------------------------IPQQIAPAPPV---- 665
            .:    .:.:.||.                                    :|....|||||
Frog   620 AS----VVRLPPGSVLAAPMPPILHAPRINVVPMPPNPPPMMAQRAPHMIVPAAFVPAPPVAPVP 680

  Fly   666 -----------DIMEEEPPSKKIRSEDNLIPEADFIATHKSPVTIQVLVPN-SDKSEWKLNGQMI 718
                       ..:|:||.:||::|||.||||.:|:..:|.|||::|.||| .||:||||.|||:
Frog   681 APAPMPPAHPPPPLEDEPAAKKMKSEDTLIPEEEFLRRNKGPVTVKVQVPNMQDKTEWKLGGQML 745

  Fly   719 AVTMALSEPIANLKTKLQDETGMPPAKQKIFYEGMFFKDSNTMAFYNLVNGTTVHLQVKERGGRK 783
            :.|:.|.:.::.:|.|:.:.||||..|||:.|:|:|.||||::|:||:.||.|:||.:|||||||
Frog   746 SFTLPLPDQVSVIKVKIHEATGMPAGKQKLQYDGIFIKDSNSLAYYNMTNGATIHLALKERGGRK 810

  Fly   784 K 784
            |
Frog   811 K 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3a1	NP_650583.1	SWAP	36..89	CDD:197818	48/52 (92%)
		Surp	150..200	CDD:280053	42/49 (86%)
		PRP21_like_P	227..479	CDD:289034	142/258 (55%)
		SF3a120_C	709..784	CDD:176395	39/74 (53%)
		UBQ	713..777	CDD:214563	30/63 (48%)
sf3a1	XP_017945285.1	SWAP	57..110	CDD:197818	48/52 (92%)
		Surp	170..220	CDD:396395	42/49 (86%)
		PRP21_like_P	237..478	CDD:403444	144/269 (54%)
		PHA03247	<551..638	CDD:223021	26/118 (22%)
		Ubl_SF3a120	722..804	CDD:340498	42/81 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	266	1.000	Domainoid score	I1854
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4294
Inparanoid	1	1.050	780	1.000	Inparanoid score	I517
OMA	1	1.010	-	-		QHG55212
OrthoDB	1	1.010	-	-		D1256232at2759
OrthoFinder	1	1.000	-	-		FOG0003484
OrthoInspector	1	1.000	-	-		oto104309
Panther	1	1.100	-	-	LDO	PTHR15316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3377
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080