DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sf3a1 and prp-21

DIOPT Version :9

Sequence 1:	NP_650583.1	Gene:	Sf3a1 / 42048	FlyBaseID:	FBgn0266917	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_493746.1	Gene:	prp-21 / 173440	WormBaseID:	WBGene00004188	Length:	655	Species:	Caenorhabditis elegans

Alignment Length:	795	Identity:	304/795 - (38%)
Similarity:	437/795 - (54%)	Gaps:	168/795 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EEQFGNDQPKSMSG-PIIGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNELGNPKFNFLNGG 73
            ||...|::| |:|| .|||:|||||::|.||||||.|.|:||.:||.:||:.|..|||||||:..
Worm     9 EEDSMNNEP-SLSGRAIIGLIYPPPDIRTIVDKTARFAAKNGVDFENKIREKEAKNPKFNFLSIT 72

  Fly    74 DPYHAYYRHKVNEFREGNDAGITALASMKQLAVTSAAQQRQQELLKQVVEQQFVPKEPPPEFEFI 138
            |||||||:..|.:|.||.                ..|.:..|.:.:.|.:.:|||..|||.:||.
Worm    73 DPYHAYYKKMVYDFSEGR----------------VEAPKVPQAVKEHVKKAEFVPSAPPPAYEFS 121

  Fly   139 ADPPSISALDLDIVKLTAQFVARNGRQFLTNLMSREQRNFQFDFLRPQHSLFQYFTKLLEQYTKV 203
            |||.:|:|.|||:::|.|.|||||||||||.||:||.||:|||||:|.|..|.|||||::||.||
Worm   122 ADPSTINAYDLDLIRLVALFVARNGRQFLTQLMTREARNYQFDFLKPAHCNFTYFTKLVDQYQKV 186

  Fly   204 LIPPKDLLGKLRSESAPGRSSMNQVLEQVKYRANWQRHQEAQRRREEEKIERERVAYAQIDWHDF 268
            |:|..:::.:|:.::    ::..:::|.:.||.:|::||:..:.|||.:.|:||.|||.||||||
Worm   187 LVPSTNVVAQLQDDA----TNKKRLIEDINYRVSWEKHQKGLKDREEAEAEKERQAYASIDWHDF 247

  Fly   269 VVVETVDYQPFESGNFPPPTNPDEVGARVLMEERLMDEEGDTEMQIESDDEGDSQANNLLDSGLK 333
            |||:|||:||.::...||...|.:||||:|:|.|       .|||
Worm   248 VVVQTVDFQPGDTSQLPPLCTPKDVGARILLEAR-------NEMQ-------------------- 285

  Fly   334 LSQMENRVGIQMKNVSSYGQPTGPKRDNTQVQDMDEA-SSDEDTPTTKLQPSVAPMLPPTHDK-V 396
                  :...:|                 |..||:|: |.|||.......|:....||||..| |
Worm   286 ------KAAAEM-----------------QEMDMEESDSDDEDAVQAPEAPAFTAPLPPTKQKDV 327

  Fly   397 VVKKYDPKATQPKQAPMPTDEYLISPITGEKIPASKVSEHMRIGLLDPRWVEQRDKHTVEKINQD 461
            :|:.|||| ....|.|...:.::|||:|||:||:.|::||:|...:|.::.|.||:|..|:..::
Worm   328 IVRDYDPK-RNVTQKPKAVENWIISPLTGERIPSDKLAEHVRYNTVDSQYKEDRDRHIGERSTEE 391

  Fly   462 NVFAAGTAIEASLKQLAERRTDIFGVGDEETVIGKKLGEEETKK--DDRVTWDGHTSSVEAATRA 524
            .|.|.|..|..:|...|||||||||||.|:|:||||||||:..:  .:::.|||...:.:..|||
Worm   392 PVLALGADISRNLGNFAERRTDIFGVGGEQTMIGKKLGEEDNSQQGQNKLIWDGTEETRDMITRA 456

  Fly   525 ARANITLEEQIHQIHKVKGLLPDEEKEKIGPKPVGNKATLSAPPQPSTKSQHSHSSQSQHHQGGG 589
            .:..:||::||::||:..|.:.|..|||||.
Worm   457 VQNKVTLDQQINEIHRQHGFVADPSKEKIGA---------------------------------- 487

  Fly   590 GGHHGHHNPHHHHPPHQQAPPHQSHHHH----------PPQQPQ---PVMQLMQLRPTMMQPPFG 641
                            ||.|.|||...:          |.|.|.   ||            ||.|
Worm   488 ----------------QQVPRHQSTQGNVTITQGITNIPGQMPSGWPPV------------PPMG 524

  Fly   642 AGGGGYMNMQPGGIPQQIAPAPPVDIME--EEPPSKKIRSEDNLIPEADFIATHKSPVTIQVLVP 704
                     .| |:|.|  ..||:..|:  ..||:|:.|:||:||||||::......:::.|.:|
Worm   525 ---------MP-GMPNQ--ALPPIRQMDFGGGPPAKRPRTEDDLIPEADWLKKVNGAISLNVHLP 577

  Fly   705 NSDKSEWKLNGQMIAVTMALSEPIANLKTKLQDETGMPPAKQKIFYEGMFFKDSNTMAFYNLVNG 769
            .:  .|..::|.::..|:.::.|::.||.::||..|||..|||:..:|:|.||:.:.|||||.:.
Worm   578 QA--PEHGMDGSIVQFTIQVTAPMSELKQQIQDRYGMPVGKQKLMSDGLFVKDNMSSAFYNLADR 640

  Fly   770 TTVHLQVKERGGRKK 784
            |.::||||||||:||
Worm   641 TAIYLQVKERGGKKK 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sf3a1	NP_650583.1	SWAP	36..89	CDD:197818	32/52 (62%)
		Surp	150..200	CDD:280053	33/49 (67%)
		PRP21_like_P	227..479	CDD:289034	88/253 (35%)
		SF3a120_C	709..784	CDD:176395	32/74 (43%)
		UBQ	713..777	CDD:214563	25/63 (40%)
prp-21	NP_493746.1	SWAP	35..88	CDD:197818	32/52 (62%)
		SWAP	132..185	CDD:197818	36/52 (69%)
		PRP21_like_P	197..409	CDD:289034	89/266 (33%)
		UBQ	577..648	CDD:214563	27/72 (38%)
		SF3a120_C	580..655	CDD:176395	32/74 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164090
Domainoid	1	1.000	156	1.000	Domainoid score	I2552
eggNOG	1	0.900	-	-		E1_KOG0007
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4294
Inparanoid	1	1.050	511	1.000	Inparanoid score	I714
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55212
OrthoDB	1	1.010	-	-		D1256232at2759
OrthoFinder	1	1.000	-	-		FOG0003484
OrthoInspector	1	1.000	-	-		oto17459
orthoMCL	1	0.900	-	-		OOG6_102246
Panther	1	1.100	-	-	LDO	PTHR15316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1278
SonicParanoid	1	1.000	-	-		X3377
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800