DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3534 and XYLB

DIOPT Version :9

Sequence 1:	NP_650582.1	Gene:	CG3534 / 42047	FlyBaseID:	FBgn0038463	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_011532627.1	Gene:	XYLB / 9942	HGNCID:	12839	Length:	823	Species:	Homo sapiens

Alignment Length:	488	Identity:	230/488 - (47%)
Similarity:	318/488 - (65%)	Gaps:	15/488 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KRTFLGFDLSTQKLKAVLLGSSLEVVAAAEVKFDTDLPEFRTTGGANAGSIKNEYFV-QPV-MWV 70
            :|..||:|.|||::|.|.:.:.|.|.....|.||.|||||.|.||.:..  |:...| .|| |||
Human     7 RRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVH--KDGLTVTSPVLMWV 69

  Fly    71 KAMDIVLDRLVMQQADLSTVAAISGSGQQHGSLYWSKHGINTLQNLDSEKFLHAQIDDSAFVVNR 135
            :|:||:|:::.....|.|.|.|:||:||||||:||.......|.:|..:..||.|:.| .|.::.
Human    70 QALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQD-CFSISD 133

  Fly   136 TPIWMDATTTKQCLEMEMAVGGKLNMVELTGSKCYERFTGPQIRKIYQQRCHAYEEANRISLVSS 200
            .|:|||::||.||.::|.||||...:..||||:.||||||.||.|||||...||....|||||||
Human   134 CPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSS 198

  Fly   201 FISSLFLGSVAPIDFSDGSGMNLLDIRKKNWSKECLNVCAPDLDKRLDIPVSPNSILGNVSPYFV 265
            |.:||||||.:|||:|||||||||.|:.|.||:.||..|||.|:::|..||...|::|.:|.|:|
Human   199 FAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYV 263

  Fly   266 ERFSFSPDCKVAASTGDNPSALSGMLVGSSWLTISMGTSDTLMMSLKEPLNWEEGHILCHPTETE 330
            :|:.|.|.|||.|.|||||::|:||.:....:.:|:||||||.:.|:||:...||||.|:|.:::
Human   264 QRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHIFCNPVDSQ 328

  Fly   331 EFMGLLCFRNASLVREEMNKKTTGGDWDKFNEYLDSTPRGNFGNMAVHFNDMEIIPKAQGILRWN 395
            .:|.||||:|.||:||::..::....|..|::.|.||..||.||:..:|:.|||.|:..|..|:|
Human   329 HYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFN 393

  Fly   396 REMDPSSPDAARGVIKFSSPQIEIRALVEGQMLHHRAVAEDLGYKFGPETQILVTGGASVNKSIL 460
            .|        ...|..|.. .:|:|||:|||.:..|..||.|||:...:|:||.|||||.|:.||
Human   394 TE--------NHKVAAFPG-DVEVRALIEGQFMAKRIHAEGLGYRVMSKTKILATGGASHNREIL 449

  Fly   461 QTIADVFNAPVHIQDEGFEAALLGAAYRSAYAL 493
            |.:||||:|||::.|.. .:|.:|:|||:.:.|
Human   450 QVLADVFDAPVYVIDTA-NSACVGSAYRAFHGL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3534	NP_650582.1	FGGY_D-XK_euk	10..491	CDD:212660	228/482 (47%)
		PLN02669	11..546	CDD:178274	229/485 (47%)
		NBD_sugar-kinase_HSP70_actin	<447..545	CDD:302596	25/47 (53%)
XYLB	XP_011532627.1	FGGY_D-XK_euk	9..479	CDD:212660	228/482 (47%)
		XylB	10..504	CDD:223996	229/485 (47%)
		trimeric_dUTPase	<582..658	CDD:294336
		HIV_retropepsin_like	678..764	CDD:133149
		G_patch	<789..822	CDD:197727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143489
Domainoid	1	1.000	188	1.000	Domainoid score	I3323
eggNOG	1	0.900	-	-		E1_COG1070
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3746
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1672
Isobase	1	0.950	-	0	Normalized mean entropy	S1469
OMA	1	1.010	-	-		QHG56396
OrthoDB	1	1.010	-	-		D335934at33208
OrthoFinder	1	1.000	-	-		FOG0004391
OrthoInspector	1	1.000	-	-		otm41376
orthoMCL	1	0.900	-	-		OOG6_104017
Panther	1	1.100	-	-	LDO	PTHR10196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1675
SonicParanoid	1	1.000	-	-		X3110
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750